A5101804594- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Connexins and lens biology
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Immune cells in cancer
- Cardiomyopathy and Myosin Studies
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Acute Ischemic Stroke Management
- Cancer Mechanisms and Therapy
- RNA regulation and disease
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- PI3K/AKT/mTOR signaling in cancer
- Selenium in Biological Systems
- Tryptophan and brain disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Congenital heart defects research
- Immune Response and Inflammation
- Redox biology and oxidative stress
Dalian Medical University
2024
Affiliated Hospital of Southwest Medical University
2018-2022
Shandong Chest Hospital
2022
University of Hong Kong
2022
Union Hospital
2022
Huazhong University of Science and Technology
2022
First Affiliated Hospital of Sichuan Medical University
2019-2022
University of Hong Kong - Shenzhen Hospital
2022
Shanghai Public Health Clinical Center
2021-2022
Jinshan Hospital of Fudan University
2015-2021
The aim of this study was to explore the potential role B7-H3 in malignant glioma progression and identify an innovative approach clinical therapy.The protein expression high- low-grade tumor tissues from patients assessed by immunohistochemistry. proliferative invasive ability B7-H3-overexpressing or knockout cells analyzed vitro vivo CCK-8 assay orthotopic mouse model, respectively. Activation JAK2/STAT3/Slug signaling pathway epithelial-mesenchymal transition (EMT) examined Western...
Impairment of innate immune cell function and metabolism underlies immunosuppression in sepsis; however, a promising therapy to orchestrate this impairment is currently lacking. In study, high levels NOD-like receptor family CARD domain containing-3 (NLRC3) correlated with the glycolytic defects monocytes/macrophages from septic patients mice that developed immunosuppression. Myeloid-specific NLRC3 deletion improved macrophage glycolysis sepsis-induced Mechanistically, inhibits nuclear...
Abstract Long non-coding RNAs (lncRNAs) have been manifested to manipulate diverse biological processes, including tumor-induced immune tolerance. Thus, we aimed in this study identify the expression pattern of lncRNA homeobox A cluster antisense RNA 2 (HOXA-AS2) glioma and decipher its role tolerance progression. We found aberrant upregulation HOXA-AS2, lysine demethylase 2A (KDM2A), jagged 1 (JAG1) a downregulation microRNA-302a (miR-302a) specimens. Next, immunoprecipitation, chromatin...
Cancer development is a complex set of proliferative progression, which arises in most cases via multistep pathways associated with various factors, including the tumor microenvironment and extracellular matrix.However, underlying mechanisms cancer remain unclear this study aimed to explore role matrix glioma progression.Methods: The expression type I collagen fibronectin tissues from patients was examined by immunofluorescence staining.The correlations between collagen/fibronectin...
Abstract Glioma is regarded as an aggressive lethal primary brain tumor. Jumonji domain containing 1C (JMJD1C) a H3K9 demethylase which participates in the progression of various tumors, but its specific function and underlying mechanism glioma development remain undefined, purpose our work. We initially assessed JMJD1C expression tissues cells using assays RT‐qPCR immunohistochemistry. Meanwhile, level at microRNA (miR)‐302a promoter region was measured by chromatin immunoprecipitation...
Matrix stiffness is a key physical characteristic of the tumor microenvironment and correlates tightly with progression. Here, we explored association between matrix glioma development. Using atomic force microscopy, observed higher in highly malignant tissues than low-grade/innocent tissues. In vitro vivo analyses revealed that culturing cells on stiff polyacrylamide hydrogels enhanced their proliferation, tumorigenesis CD133 expression. Greater could obviously up-regulated expression...
LIM and SH3 protein 1 (LASP1) is upregulated in several types of human cancer implicated progression. However, the expression intrinsic function LASP1 glioblastoma (GBM) remains unclear.Oncomine The Cancer Genome Atlas (TCGA) database was analyzed for clinical significance GBM. mRNA level were measured by qRT-PCR western blotting. effect on GBM proliferation examined MTT assay colony formation assay, sensitivity Temozolomide flow cytometry subcutaneous tumor model. association between...
This study investigated the underlying mechanism of LIM and SH3 protein 1 (LASP1)-induced malignant glioma growth invasion.We compared expression LASP1 in tumor tissues low-grade by immunohistochemistry. We also overexpression knockout cell proliferation invasion vitro vivo. detected activation PI3K/AKT signaling pathway epithelial-mesenchymal transition (EMT) process cells western blotting or immunofluorescence. Glioma-bearing mice were used to investigate anticancer effects inhibitors...
Circular RNA phosphorylase kinase regulatory subunit alpha 2 (circPHKA2; hsa_circ_0090002) has a significantly, specifically different expression in acute ischemic stroke (AIS) patients' blood. Here, we intended to investigate the role and mechanism of circPHKA2 oxygen-glucose deprivation- (OGD-) induced stoke model human brain microvascular endothelial cells (HBMEC).Expression circPHKA2, microRNA- (miR-) 574-5p, superoxide dismutase-2 (SOD2) was detected by quantitative PCR western...
Low-intensity pulsed ultrasound (LIPUS), which has been previously reported to promote bone repair, is proposed be a noninvasive form of therapy for the treatment osteonecrosis. Bone fillers made from composite scaffolds have demonstrated effective preventing defects such as The present study aimed investigate whether application LIPUS combined with morphogenetic protein-2 (BMP-2)-loaded poly-L-lactic acid/polylactic-co-glycolic acid/poly-ε-caprolactone (PLLA/PLGA/PCL) can improve recovery...