Intracerebral hemorrhage (ICH), a severe hemorrhagic stroke, induces cerebral oxidative stress and secondary neurological injury. Curcumin was demonstrated to inhibit in the brain after ICH. However, pharmacological mechanism needs further research. We used an intrastriatal injection of autologous blood make rat ICH model, then treated with curcumin (100 mg/kg/day). Modified Neurological Severity Score (mNSS) corner test results showed that could significantly promote recovery rats....

Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by high mortality and disability rates. The long-term effects ICH-induced intracranial hematoma on patients' neurological function are unclear. Currently, an effective treatment that significantly reduces the rates death in patients with ICH not available. Based accumulating evidence, ferroptosis may be leading factor contributing to impairment caused injury. Peroxisome proliferator-activated receptor γ (PPARγ)...

Abstract Brain metastases (BMs) usually develop in breast cancer (BC) patients. Thus, the molecular mechanisms of brain metastasis (BCBM) are great importance designing therapeutic strategies to treat or prevent BCBM. The present study attempted identify novel diagnostic and prognostic biomarkers Two datasets (GSE125989 GSE100534) were obtained from Gene Expression Omnibus (GEO) database find differentially expressed genes (DEGs) cases BC with without (BM). A total 146 overlapping DEGs,...

Ectopic expression of the TrkA receptor tyrosine kinase in tumors nervous system can mediate nerve growth factor (NGF)-dependent cell death by apoptosis and /or autophagy. Herein, we demonstrate that also induce medulloblastoma Daoy cells a caspase-independent mechanism involves hyperstimulation macropinocytosis. Specifically, NGF-stimulates uptake AlexaFluor546-dextran into lysosome-associated membrane protein-1 positive vacuoles which fuse with microtubule associated protein light chain 3...

Background: As lung cancer has shown a continuously increasing trend in many countries, it is essential to stay abreast of mortality information and take informed actions with theoretical basis derived from appropriate practical statistical methods. Methods: Age-specific rates were collected by gender region (urban/rural) analysed descriptive methods age-period-cohort models estimate the trends China 1988 2013. Results: Descriptive analysis revealed that age-specific rural residents...

Glioblastoma multiforme (GBM) is a prevalent and aggressive disease, the development of novel therapy to better treat advanced GBM urgently required. Lactate dehydrogenase A (LDHA), which functions as key enzyme in transforming pyruvate into lactate, has attracted more attention recent years due its critical role various types cancer. Previous data derived from Oncomine database have shown that expression LDHA higher tissues than corresponding normal control tissues. However, association...

Although the memory- improving effect of crocin has been suggested by previous evidences, association between this and hippocampal acetylcholine (Ach) level apoptosis is not well investigated. This study aimed to determine protective effects on memory, Ach level, in a rat model cerebral ischemia. Male Wistar rats were divided into sham group received saline, other 3 groups underwent 4-vessel occlusion brain ischemia (4VOI), oral administration either saline or doses 30 mg/day 60 for 7 days....

Cyclic GMP-AMP synthase (cGAS), serving as a primary sensor of intracellular DNA, is essential to initiate anti-microbial innate immunity. Inappropriate activation cGAS by self-DNA promotes severe autoinflammatory diseases such Aicardi–Goutières syndrome (AGS); thus, inhibition may provide therapeutic benefit in anti-autoimmunity. Here we report that perillaldehyde (PAH), natural monoterpenoid compound derived from Perilla frutescens , suppresses cytosolic-DNA-induced immune responses...

Background: Early assessment and management of cerebral edema hematoma following aneurysmal subarachnoid hemorrhage (a-SAH) can significantly impact clinical cognitive outcomes. However, current practices lack predictive models to identify early structural brain abnormalities affecting cognition. To address this gap, we propose the development a model termed a-SAH Brain Edema/Hematoma Compression Neural (Structural Brain) Networks Score System (SEBE-HCNNSS). Methods: In study, 202...

Breast cancer is the most common cause of cancer—related death among women. In this paper, we studied variations in trends Chinese female breast mortality by age, period and cohort from 1990 to 2009. The data were collected Institute for Health Metrics Evaluation. An age-period-cohort model Intrinsic Estimator used estimate age effect, effect on adult risk. initially increased, but then declined, showed a reversed "J" shape with age. continued rise time increased 59 % 1990–1994 2005–2009....

To describe the temporal trends of breast cancer mortality in East Asia and to better understand causes these trends, we analyzed independent effects chronological age, time period birth cohort on using age-period-cohort (APC) analysis. We chose three main countries Asia, namely China, South Korea, Japan, which have reported death status WHO Mortality Database, used United States as a comparison population. Our study shows that general, rates females increased all Asian throughout period. By...

Systemic inflammatory response syndrome (SIRS) is a sepsis-associated state and self-defense mechanism against specific nonspecific stimuli. Ketamine influences many key processes that are altered during sepsis. However, the underlying mechanisms remain incompletely understood. In this study, TNF-α-treated mice, as well HT-29 L929 cell models, were applied to characterize TNF-α-induced systemic local cecal tissue responses. Behavioral, biochemical, histological, molecular biological...

Objective: This study aimed to evaluate the clinical outcomes of a combined surgical approach involving carotid endarterectomy (CEA) and artery stenting (CAS) for management patients with severe bilateral atherosclerotic stenosis. Methods: A retrospective analysis was conducted on data 19 diagnosed stenosis who were hospitalized between June 2019 January 2022. The efficacy CEA CAS analyzed. Results: Postoperative imaging confirmed complete resolution stenosis, restored lumen patency,...

Exposure to second-hand smoke (SHS) is linked ischemic heart disease (IHD), but research on burden in China and across socio-demographic index (SDI) regions limited. Based the Global Burden of Disease 2021, we used joinpoint regression age-period-cohort model analyze trend deaths disability-adjusted life years (DALYs) IHD attributable SHS five SDI from 1990 2021. Results showed that age-standardized rates death DALY remained at a high level, declined more slowly compared regions. The...

Purpose Design concept evaluation overwhelmingly impacts product development. This study aims to enhance uncertainty representation in the design process, consider impact of evaluators’ cognitive bias on results and improve credibility results. Design/methodology/approach proposes an integrated approach for based interval-valued Pythagorean fuzzy set (IVPFS) consensus model. In this study, we introduced IVPFS represent preferences evaluators, then built a model mathematical operators measure...

Circadian dysregulation involved in the pathophysiology of spinal cord injury (SCI). Modulation circadian rhythms hold promise for SCI treatment. Here, we aim to investigated mechanism olfactory ensheathing cells (OEC) alleviating neuroinflammation via modulating clock gene expression microglia. In this study, rats were randomly divided into OEC group and vehicle group. At 1 day after surgery, OECs intravenously transplanted rat, while received culture medium. After 7 days post...