A5101944805- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Ultrasound and Hyperthermia Applications
- Medical Imaging and Analysis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Peptidase Inhibition and Analysis
- Nanoplatforms for cancer theranostics
- Head and Neck Surgical Oncology
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Neurological Disorders and Treatments
- Cytokine Signaling Pathways and Interactions
- Peripheral Artery Disease Management
- interferon and immune responses
- Stroke Rehabilitation and Recovery
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
Tianjin Huanhu Hospital
2015-2025
Affiliated Hospital of Hebei University
2025
Tianjin Medical University
2022-2024
Qilu Hospital of Shandong University
2024
Tianjin Central Hospital of Gynecology Obstetrics
2009-2023
Tianjin International Joint Academy of Biomedicine
2022
Nankai University
2018-2022
Research Institute of Petroleum Exploration and Development
2016
University of Strathclyde
2015
First Hospital of China Medical University
2015
This paper evaluates the recoverable unconventional oil and gas resources around world, reveals main controlling factors potential regions for rich accumulation of gas, standardizes classification seven types (i.e., heavy oil, sand, tight shale, shale coalbed methane). By virtue commercial databases global petroliferous basins, together with single-well data packages in North America basic exploration development Chinese companies blocks contour maps abundance are formed through spatial...
Importance Prior trials of extracranial-intracranial (EC-IC) bypass surgery showed no benefit for stroke prevention in patients with atherosclerotic occlusion the internal carotid artery (ICA) or middle cerebral (MCA), but there have been subsequent improvements surgical techniques and patient selection. Objective To evaluate EC-IC symptomatic ICA MCA, using refined operator Design, Setting, Participants This was a randomized, open-label, outcome assessor–blinded trial conducted at 13...
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer, it remains a huge challenge to understand cellular and molecular mechanisms of aggressive behavior EOC cells. Here we investigated role an immunomodulatory cytokine IL‐33 its receptor ST2 in mediating growth metastasis EOC. Our data show that both were highly up‐regulated tumors compared with normal ovary benign tumors, expression levels further increased tumor tissues at metastatic site. The positively correlated Ki‐67...
Medulloblastoma is the neuroepithelial tumor with highest degree of malignancy in central nervous system, accounting for about 8% to 10% children's brain tumors. It has a high and easily transmitted through cerebrospinal fluid, relatively poor prognosis. Although medulloblastoma been widely studied treated, its molecular mechanism remains unclear. To determine which gene plays crucial role development progression, we analyzed three microarray datasets from Gene Expression Omnibus. Ontology...
Abstract Objective This study was undertaken to develop a deep learning framework that can classify and segment interictal epileptiform discharges (IEDs) in multichannel electroencephalographic (EEG) recordings with high accuracy, preserving both spatial information interchannel interactions. Methods We proposed novel framework, U‐IEDNet, for detecting IEDs EEG. The U‐IEDNet employs convolutional layers bidirectional gated recurrent units as temporal encoder extract features from...
Patients with symptomatic internal carotid artery (ICA) or middle cerebral (MCA) occlusion haemodynamic insufficiency are at high risk for recurrent stroke when treated medically. The Carotid Middle Occlusion Surgery Study (CMOSS) trial is an ongoing, government-funded, prospective, multicentre, randomised controlled trial. CMOSS will recruit 330 patients ICA MCA (parallel design, 1:1 allocation ratio) and insufficiency. Participants be allocated to best medical treatment alone medicine plus...
Background: In the Carotid or Middle cerebral artery Occlusion Surgery Study (CMOSS), we found no significant difference between bypass surgery group and medical with respect to primary composite outcome of stroke death within 30 days any subsequent ipsilateral ischemic 2 years follow-up. We now extend long-term follow-ups 10 years. Methods: randomly assigned symptomatic patients hemodynamically compromised internal carotid (ICA) middle (MCA) occlusion extracranial-intracranial (EC-IC) plus...
Objective: This study aimed to evaluate the clinical outcomes of a combined surgical approach involving carotid endarterectomy (CEA) and artery stenting (CAS) for management patients with severe bilateral atherosclerotic stenosis. Methods: A retrospective analysis was conducted on data 19 diagnosed stenosis who were hospitalized between June 2019 January 2022. The efficacy CEA CAS analyzed. Results: Postoperative imaging confirmed complete resolution stenosis, restored lumen patency,...
The hippocampal CA1 region is sensitive to hypoxic and ischemic injury but can be protected by preconditioning (IPC). However, the mechanism through which IPC protects neurons still under investigation. Additionally, role of autophagy in determining fate unclear. Here, we examined whether induced alleviate neuronal death vitro vivo with oxygen glucose deprivation (OGD) bilateral carotid artery occlusion (BCCAO) models. Survival increased from 51.5% ± 6.3% non-IPC group (55 min OGD) 77.3%...
Cancer stem cells, quiescent and drug resistant, have become a therapeutic target. Unlike high-intensity focused ultrasound directly killing tumor, low-intensity pulsed (LIPUS), new noninvasive physical device, promotes pluripotent cell differentiation is primarily applied in tissue engineering but rarely oncotherapy. We explored the effect mechanism of LIPUS on glioma (GSC) expulsion from quiescence. Here, we observed that led to attenuated expression GSC biomarkers, promoted escape G0...
Background: Gliomas are the most common intracranial malignant neoplasms and have high recurrence mortality rates. Recent literatures reported that centromere protein N (CENPN) participates in tumor development. However, clinicopathologic significance biological functions of CENPN glioma still unclear. Methods: Clinicopathologic data gene expression profiles cases downloaded from The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) databases were utilized to determine associations between...
High-sensitivity C-reactive protein (hs-CRP) is not only a marker of inflammation but also prognostic factor for ischemic stroke. The objective our study was to investigative the association between hs-CRP levels and outcomes patients with small-artery occlusion (SAO).We selected 718 participants diagnosed SAO (according Trial Org 10172 in Acute Stroke Treatment classification) using stroke registry Department Neurorehabilitation Tianjin HuanHu Hospital. Hs-CRP values at admission were...
Excessive inflammation leads to secondary immune damage after traumatic brain injury (TBI). The intestinal mucosa is a key component of tolerance due gut-brain axis regulation, but the curative effect not optimal. Intestinal dysfunction impairs establishment in patients with TBI. Therefore, we orally administered protein (BP) combined probiotics induce and explored mechanism by which homeostasis microbiota contributes enhancement effects BPs. Herein, demonstrated that TBI surgical (SBI)...
Abstract BACKGROUND Posterior circulation ischemic strokes can have devastating consequences, despite medical therapies. Extracranial–intracranial bypass for the augmentation of flow is a treatment option selected patients with hemodynamic compromise and recurrent ischemia. However, posterior carries higher risk lower patency rate than anterior circulation. OBJECTIVE To present occipital artery to extradural vertebral (OA-eVA) METHODS We retrospectively reviewed our experience OA-eVA surgery...
Glioma stem cells (GSCs) are a sub-population of cancer with capacity self-renewal and differentiation. Accumulated evidence has revealed that GSCs were shown to contribute gliomagenesis, distant metastasis as well the resistance radiotherapy chemotherapy. As result, regarded promising therapeutic target in human glioma. The purpose our study is identify current state hotspots research by analyzing scientific publications through bibliometric methods.All relevant on during 2003-2021...
The authors aimed to elucidate the relationship between latest ischemic event and incidence of subsequent stroke in patients with symptomatic artery occlusion.
Objectives: (1) To investigate the expression patterns of MΦ1 and MΦ2 phenotype markers peripheral blood monocyte (PBMC)-derived macrophages in atherosclerosis patients healthy controls, as well correlation among these genes. (2) elucidate whether a high level liver X receptor α (LXRα) is associated with anti-inflammatory MΦ2-type polarization.Design: Peripheral monocytes (PBMCs) were obtained from 28 carotid artery plaques 10 normal persons, who did not have plaques. M1 M2 analyzed after...