A5100760396- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Autophagy in Disease and Therapy
- Impact of Technology on Adolescents
- Cerebrovascular and Carotid Artery Diseases
- Lung Cancer Treatments and Mutations
- Extracellular vesicles in disease
- Mental Health Research Topics
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Supercapacitor Materials and Fabrication
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Cardiovascular Health and Disease Prevention
- Advanced battery technologies research
- Acute Ischemic Stroke Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Traumatic Brain Injury Research
- Endoplasmic Reticulum Stress and Disease
- Immunotherapy and Immune Responses
- Advancements in Battery Materials
Jiangsu University
2002-2025
Renji Hospital
2015-2025
Shanghai Jiao Tong University
2016-2025
East China Normal University
2008-2025
Southwest Medical University
2025
Ruijin Hospital
2024-2025
Huazhong Agricultural University
2025
Shanghai Chest Hospital
2016-2024
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Recent studies suggest that Internet gaming addiction (IGA) is an impulse disorder, or at least related to control disorders. In the present study, we hypothesized different facets of trait impulsivity may be specifically linked brain regions with impaired inhibition function in IGA adolescents. Seventeen adolescents and seventeen healthy controls were scanned during performance a response-inhibition Go/No-Go task using 3.0 T MRI scanner. The Barratt Impulsiveness Scale (BIS)-11 was used...
Quantitative susceptibility mapping (QSM) is a novel MRI technique for the measurement of tissue magnetic in three dimensions. Although numerous algorithms have been developed to solve this ill-posed inverse problem, estimation maps with wide range values still problematic. In cases such as large veins, contrast agent uptake and intracranial hemorrhages, extreme focal areas cause severe streaking artifacts. To enable reduction these artifacts, whilst preserving subtle contrast, two-level QSM...
Abstract Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary physicians (PCPs), particularly in low-resource settings. Here, bridge the gaps, we developed an integrated image–language system (DeepDR-LLM), combining large language model (LLM module) image-based deep learning (DeepDR-Transformer), provide individualized management recommendations PCPs. In retrospective evaluation, LLM module demonstrated...
Purpose Excessive use of the Internet has been linked to a variety negative psychosocial consequences. This study used resting-state functional magnetic resonance imaging (fMRI) investigate whether connectivity is altered in adolescents with gaming addiction (IGA). Methods Seventeen IGA and 24 normal control underwent 7.3 minute fMRI scan. Posterior cingulate cortex (PCC) was determined all subjects by investigating synchronized low-frequency signal fluctuations using temporal correlation...
The aim of this study was to determine the effects long-term Nicotinamide mononucleotide (NMN) treatment on modulating gut microbiota diversity and composition, as well its association with intestinal barrier function. In study, C57BL/6J mice were fed different concentrations NMN, their feces collected for detection 16S rDNA non-targeted metabolites explore NMN metabolites. results revealed that increased abundance butyric acid-producing bacteria (Ruminococcae_UCG-014...
Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease mainly involving the colon and rectum, which features recurrent mucosal inflammation. The excessive production of reactive oxygen species (ROS) trigger for pathological changes such as cell apoptosis disordered immune microenvironments, are crucial progression UC can be promising therapeutic target. Nowadays, development targeted strategies still in its infancy. Thus, developing effective therapies based on ROS...
Abstract Reduced lymphoid enhancer-binding factor 1 (LEF1) expression in patients with adenomyosis during the mid-secretory phase leads to impaired endometrial receptivity, affecting embryo implantation. This study investigated molecular mechanisms underlying reduced receptivity 25 and controls. Functional experiments were conducted using human stromal cells (HESCs) TERT-immortalized HESCs(T-HESCs), final validation performed a mouse model. Western blot quantitative real-time polymerase...
Abstract Objectives The aim of this study was to determine the status tertiary lymphoid structures (TLSs) using radiomic features in patients with invasive pulmonary adenocarcinoma (IA). Methods In retrospective study, IA from November 2015 March 2024 were recruited two independent centers (center 1, training and internal test data set; center 2, external set). TLS divided into groups according hematoxylin-eosin staining. Radiomic extracted, support vector machine (SVM) implemented predict...
Abstract Background Intratumor heterogeneity (ITH) is a key biological characteristic of gliomas. This study aimed to characterize ITH in adult-type diffuse gliomas and assess the feasibility using habitat imaging based on dynamic contrast-enhanced magnetic resonance (DCE-MRI) diffusion-weighted (DWI) preoperatively predict isocitrate dehydrogenase (IDH) genotypes prognosis. Methods Sixty-three with known IDH were enrolled. Volume transfer constant (K trans ) apparent diffusion coefficient...
Internet addiction disorder (IAD) is increasingly recognized as a mental health disorder, particularly among adolescents. The pathogenesis associated with IAD, however, remains unclear. In this study, we aim to explore the encephalic functional characteristics of IAD adolescents at rest using magnetic resonance imaging data. We adopted graph-theoretic approach investigate possible disruptions connectivity in terms network properties including small-worldness, efficiency, and nodal centrality...
Setd2 is known as a histone-H3K36-specific methyltransferase. However, its role in physiological function remains unclear. In this study, we show that mainly regulates differentiation of murine embryonic stem cells (mESCs) toward primitive endoderm. Furthermore, downregulated endoderm-related genes Setd2−/− mESCs are associated with an aberrantly low level Erk activity and enforced expression Fgfr3 can rescue the defective pathway mESCs. Interestingly, transcriptional initiation directly...
Purposes Recent neuroimaging studies have shown that people with Internet gaming disorder (IGD) structural and functional abnormalities in specific brain areas connections. However, little is known about the alterations of interhemispheric resting-state connectivity (rsFC) participants IGD. In present study, we used a newly developed voxel-mirrored homotopic (VMHC) method to investigate rsFC whole Methods We compared between 17 IGD 24 healthy controls, group-matched on age, gender, education...
Although lungs are densely innervated by the peripheral nervous system (PNS), role of PNS in progression lung cancer is unknown. In this study, we report that mouse adult Schwann cells (SC), principal glial PNS, can regulate motility vitro and formation metastases vivo SCs promoted epithelial-to-mesenchymal transition (EMT) two cell lines increasing expression Snail Twist tumor cells; blocking abolished SC-induced cells. SC-derived CXCL5 was responsible for EMT cells, as inhibition or its...
The relationship between chronic kidney disease and cerebral small vessel (cSVD), especially enlarged perivascular spaces (EPVS), has not been fully understood. This study aimed to investigate the association of EPVS, as well total burden cSVD on magnetic resonance imaging, expressed by simultaneous presence multiple markers cSVD, among patients with first-ever lacunar stroke.Four hundred thirteen consecutive were prospectively enrolled. Centrum semiovale basal ganglia EPVS T2-weighted other...
In recent years, autophagy was found to regulate lipid metabolism through a process termed lipophagy. Lipophagy modulates the degradation of cholesteryl esters free cholesterol (FC), which is substrate testosterone biosynthesis. However, role lipophagy in production unknown. To investigate this, primary rat Leydig cells and varicocele models were administered inhibit or promote autophagy, testosterone, droplets (LDs), total (TC), FC evaluated. The results demonstrated that inhibiting reduced...
Although recent studies have clearly demonstrated functional and structural abnormalities in adolescents with internet gaming addiction (IGA), less is known about how IGA affects perfusion the human brain. We used pseudocontinuous arterial spin-labeling (ASL) magnetic resonance imaging (fMRI) to measure effects of on resting brain functions by comparing cerebral blood flow normal subjects.Fifteen 18 matched underwent fMRI state. Direct subtraction, voxel-wise general linear modeling was...
Non-alcoholic fatty liver disease, one of the most common diseases, has obtained increasing attention. Palmitate (PA)-induced injury is considered a risk factor for development non-alcoholic disease. Autophagy, cellular degradative pathway, an important self-defense mechanism in response to various stresses. In this study, we investigated whether autophagy plays protective role progression PA-induced hepatocytes injury.Annexin V-FITC/PI staining by FCM analysis, TUNEL assay and detection...
Abstract Hepatic carcinoma (HCC) is a lethal disease associated with high morbidity and poor prognosis. Recently years, gene therapies have offered novel modalities to improve the prognosis of HCC patients. MicroRNA-99a (miR-99a) frequently down-regulated in HCC, where it acts as tumor suppressor. Therefore, we constructed monomethoxy (polyethylene glycol)-poly(D,L-lactide- co -glycolide)-poly(L-lysine)-lactobionic acid- anti-vascular endothelial growth factor antibody...
Cognitive behavior therapy (CBT) is effective for the treatment of Internet gaming disorder (IGD). However, mechanisms by which CBT improves IGD-related clinical symptoms remain unknown. This study aimed to discover therapeutic mechanism in IGD subjects using resting-state functional magnetic resonance imaging (rsfMRI). Twenty-six and 30 matched healthy controls (HCs) received rsfMRI scan assessments; 20 completed then were scanned again. The amplitude low-frequency (ALFF) values...