A5028875162- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and genetic disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Atrial Fibrillation Management and Outcomes
- Alzheimer's disease research and treatments
- Moyamoya disease diagnosis and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Coronary Interventions and Diagnostics
- Cerebral Venous Sinus Thrombosis
- Protease and Inhibitor Mechanisms
- Dysphagia Assessment and Management
National Clinical Research Center for Digestive Diseases
2020-2025
Capital Medical University
2020-2025
Beijing Tian Tan Hospital
2020-2025
Soochow University
2017-2025
First Affiliated Hospital of Soochow University
2017-2025
Chinese Institute for Brain Research
2021-2024
First Affiliated Hospital of Wannan Medical College
2024
Wannan Medical College
2024
Children's Hospital of Capital Institute of Pediatrics
2023
Daiichi Sankyo (United States)
2023
Background and Purpose— Symptomatic intracranial hemorrhage (SICH) pose a major safety concern for endovascular treatment of acute ischemic stroke. This study aimed to evaluate the risk related factors SICH after in real-world practice. Methods— Patients with stroke treated stent-like retrievers recanalizing blocked artery anterior circulation were enrolled from 21 centers China. Intracranial was classified as symptomatic asymptomatic ones according Heidelberg Bleeding Classification....
<i>Background/Aims:</i> To evaluate the psychometric properties of Hong Kong Montreal Cognitive Assessment (HK-MoCA) in patients with cerebral small vessel disease (SVD). <i>Methods: </i>40 SVD and 40 matched controls were recruited. Concurrent criterion validity, inter-rater test-retest reliability, internal consistency HK-MoCA examined clinical observations made. <i>Results:</i> Performance on was significantly predicted by both executive (β = 0.23, p...
Estimated glucose disposal rate (eGDR), a simple and noninvasive measure of insulin resistance, has been proven to be an independent risk factor for first-time stroke all-cause mortality. In this study, we aimed investigate the associations between eGDR outcome in patients with acute ischemic (AIS).We included AIS available data on China National Stroke Registry III (CNSR-III), divided subjects into lower group (eGDR ≤ 6 mg/kg/min) higher > mg/kg/min). The primary was excellent functional...
Although intravenous thrombolysis with alteplase remains the primary treatment for acute ischemic stroke, tenecteplase has shown potential advantages over alteplase. Animal studies have demonstrated favorable pharmacokinetics and pharmacodynamics of tenecteplase. Moreover, it is easier to administer. Clinical trials that not inferior may even be superior in cases stroke large vessel occlusion. Current evidence supports time cost benefits tenecteplase, suggesting could potentially replace as...
Background The benefit–risk profile of tenecteplase in the elderly patients with acute ischaemic stroke (AIS) is uncertain. We sought to investigate efficacy and safety 0.25 mg/kg compared alteplase for AIS aged ≥80 years. Methods performed a post hoc analysis Tenecteplase Reperfusion Therapy Acute Ischaemic Cerebrovascular Events-2 Trial, randomised, phase 3, non-inferiority clinical trial. Disabling years who initiated intravenous thrombolytics within 4.5 hours symptom onset were enrolled...
Background The benefit of intravenous alteplase in acute ischaemic stroke (AIS) is time-dependent. Tenecteplase non-inferior to among patients with AIS. We aimed delineate the association onset treatment time (OTT) tenecteplase compared on therapeutic and clinical risks. Methods This a post hoc analysis Reperfusion therapy Acute Cerebrovascular Events-2 an open-label, randomised, controlled, trial. A total 1430 AIS within 4.5 hours at 53 sites China from 12 June 2021 29 May 2022 were...
Importance Trials have not demonstrated superiority of alteplase or tenecteplase vs standard care in patients with mild stroke and raised safety concerns. Prourokinase is an alternative fibrinolytic that may a favorable profile, the benefit-risk profile prourokinase unknown. Objective To investigate efficacy ischemic within 4.5 hours symptom onset. Design, Setting, Participants This was multicenter, prospective, open-label, blinded–end point randomized clinical trial conducted from November...
Abstract Background We hypothesized that chronic brain changes are important substrates for incident dementia after stroke and transient ischemic attack (TIA). Methods compared clinical imaging features between patients with consecutive stroke/TIA (n = 88) without 925) at 3 to 6 months a stroke/TIA. Pittsburg compound B (PiB) positron emission tomography was performed in 50 patients, including those 37) 13) dementia. Results Age, history of diabetes mellitus, severity white matter (WMCs),...
Age-related white matter changes (WMC) are considered manifestation of arteriolosclerotic small vessel disease and related to age vascular risk factors. Most recent studies have shown that WMC associated with a host poor outcomes, including cognitive impairment, dementia, urinary incontinence, gait disturbances, depression, increased stroke death. Although the clinical relevance has been extensively studied, date, only very few trials evaluated potential symptomatic or preventive treatments...
Background and purpose Repetitive transcranial magnetic stimulation ( rTMS ) changes the excitability of motor cortex thereby has potential to enhance recovery after stroke. This randomized, sham‐controlled, double‐blind study was compare effects high‐frequency versus low‐frequency on during early phase stroke identify neurophysiological correlates improvements. Methods A total 69 first‐ever ischemic patients with deficits were randomly allocated receive five daily sessions 3‐Hz ipsilesional...
Sex differences in stroke outcomes are crucial to secondary prevention, but previous reports showed inconsistent results. We aimed explore the sex Third China National Stroke Registry, a prospective multicenter registry study.Among 15 166 patients enrolled between 2015 and 2018, 9038 with acute ischemic (AIS) were included. The primary recurrence, mortality, unfavorable functional outcome (modified Rankin Scale > 2) at 3, 6, 12 months. Cox regression model was used for recurrence mortality...
Background and Purpose— We explored the association between pulsatility index (PI) as derived from transcranial Doppler ultrasound with various measures of small vessel disease in community. Methods— performed magnetic resonance imaging 205 consecutive community-dwelling elderly subjects who were participants Shanghai Aging Study. investigated middle cerebral artery (MCA) PI white matter lesions (WML), lacunes, microbleeds. Results— Multiple logistic regression found that MCA was associated...
Elevated concentrations of homocysteine are associated with cerebral small vessel disease (CSVD). B-vitamin supplementation folate and vitamins B12 B6 reduces concentrations. In a substudy the VITAmins TO Prevent Stroke (VITATOPS) trial, we assessed hypothesis that addition once-daily supplements B would reduce progression CSVD-related brain lesions.A total 359 patients recent stroke or transient ischemic attack, who were randomly allocated to double-blind treatment placebo b vitamins,...
<b><i>Background and Objective:</i></b> Endovascular treatment (EVT) is proven to be safe effective for treating acute large vessel occlusion stroke (LVOS). The neutrophil-lymphocyte ratio (NLR) reflects systemic inflammation, which plays an important role in the process of ischemic stroke. This study aims explore relationship between NLR clinical outcomes LVOS patients undergoing EVT. <b><i>Methods:</i></b> Patients were selected from EVT...
The relationship between chronic kidney disease and cerebral small vessel (cSVD), especially enlarged perivascular spaces (EPVS), has not been fully understood. This study aimed to investigate the association of EPVS, as well total burden cSVD on magnetic resonance imaging, expressed by simultaneous presence multiple markers cSVD, among patients with first-ever lacunar stroke.Four hundred thirteen consecutive were prospectively enrolled. Centrum semiovale basal ganglia EPVS T2-weighted other...
It was recently demonstrated that cerebral microinfarcts (CMIs) can be detected in vivo using 3.0 tesla (T) magnetic resonance imaging. We investigated the prevalence, risk factors, and longitudinal cognitive consequence of cortical CMIs on 3.0T imaging, patients with ischemic stroke or transient attack.A total 231 undergoing imaging were included. Montreal Cognitive Assessment used to evaluate global functions domains (memory, language, attention visuospatial executive functions). changes...
<b><i>Backgrounds and Purpose:</i></b> This study was aimed at investigating the outcomes predictors for poor functional outcome after endovascular treatment (EVT) in a large, mostly Asian population. <b><i>Methods:</i></b> Between January 2014 June 2016, acute stroke patients with anterior circulation occlusion EVT were retrospectively enrolled from 21 centers China. The main modified Rankin Scale (0-2 as independence, 3-6 poor) 90 days,...
Thrombo-inflammation is an important checkpoint that orchestrates infarct development in ischemic stroke. However, the underlying mechanism remains largely unknown. Here, we explored role of endothelial Caveolin-1 (Cav-1) cerebral thrombo-inflammation.The correlation between serum Cav-1 level and clinical outcome was analyzed acute stroke patients with successful recanalization. Genetic manipulations by endothelial-specific adeno-associated virus (AAV) siRNA were applied to investigate...
Background and Aim Studies in stroke patients suggest that lacunar intracerebral hemorrhage might be more common Chinese than Whites. We hypothesized other manifestations of subclinical cerebral small vessel disease, namely white matter hyperintensities (WMH), lacunes, microbleeds, are also compared the community prevalence these lesions between Han White Australians. Methods Magnetic resonance imaging (1·5-Tesla) was performed on participants Shanghai Aging Study ( n = 321, mean age 69 ± 6...
Background and purpose Whether intravenous thrombolysis prior to endovascular treatment in patients with anterior circulation large‐vessel occlusion ( LVO ) is indispensable remains unclear. The aim was retrospectively compare, a Chinese population, the effectiveness safety of direct DEVT initiated within 4.5 h after onset bridging therapy acute stroke patients. Methods A total 363 patients, 160 group 203 group, were enrolled between 2014 2016. Using propensity score matching analysis, 276...