A5102948958- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Neuroscience of respiration and sleep
- Soft Robotics and Applications
- Circular RNAs in diseases
- RNA Research and Splicing
- Advanced Technologies in Various Fields
- Teleoperation and Haptic Systems
- Sulfur Compounds in Biology
- Thermal Regulation in Medicine
- Chemical Reactions and Isotopes
- Virtual Reality Applications and Impacts
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Pharmacogenetics and Drug Metabolism
- Artificial Intelligence Applications
- Zebrafish Biomedical Research Applications
- Acute Ischemic Stroke Management
- Immune Response and Inflammation
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Molecular Communication and Nanonetworks
- Cell death mechanisms and regulation
- Ultrasound and Hyperthermia Applications
Nanjing University
2012-2024
Nanjing General Hospital of Nanjing Military Command
2012-2024
Jinling Institute of Technology
2020-2023
Southern Medical University
2019-2023
East China Normal University
2015-2021
Importance Trials have not demonstrated superiority of alteplase or tenecteplase vs standard care in patients with mild stroke and raised safety concerns. Prourokinase is an alternative fibrinolytic that may a favorable profile, the benefit-risk profile prourokinase unknown. Objective To investigate efficacy ischemic within 4.5 hours symptom onset. Design, Setting, Participants This was multicenter, prospective, open-label, blinded–end point randomized clinical trial conducted from November...
Combinatorial drug therapy can improve the therapeutic effect and reduce corresponding adverse events. In silico strategies to classify synergistic vs antagonistic pairs is more efficient than experimental strategies. However, most of developed methods have been applied only cancer therapies. this study, we introduce a novel method, XGBoost, based on five features drugs biomolecular networks their targets, combinations from different categories. We found that XGBoost outperformed other...
Emergent evidences revealed that long noncoding RNAs (lncRNAs) participate in neoplastic progression. HMMR is an oncogene highly expressed glioblastoma (GBM) and supports GBM growth. Whether lncRNAs regulate remains unknown. Herein, we identify antisense lncRNA, HMMR-AS1, hyperexpressed cell lines stabilizes mRNA. Knockdown of HMMR-AS1 reduces expression; inhibits migration, invasion, mesenchymal phenotypes; suppresses growth both vitro vivo. Moreover, knockdown radiosensitizes by reducing...
The rat is an important model organism in biomedical research for studying human disease mechanisms and treatments, but its annotated transcriptome far from complete. We constructed a Rat Transcriptome Re-annotation named RTR using RNA-seq data 320 samples 11 different organs generated by the SEQC consortium. Totally, there are 52 807 genes 114 152 transcripts RTR. Transcribed regions exons account ∼42% ∼6.5% of genome, respectively. Of all 73 074 newly RTR, 34 213 were as high confident...
It has been proven that nuclear factor-kappa B (NF- κ B) is activated as a well-known transcription factor after subarachnoid hemorrhage (SAH). However, the panoramic view of NF- activity SAH remained obscure. Cultured neurons were signed into control group and six hemoglobin- (Hb-) incubated groups. One-hemorrhage rabbit model was produced, rabbits divided randomly one five detected by electrophoretic mobility shift assay (EMSA) immunohistochemistry. Real-time polymerase chain reaction...
Both hydrogen sulphide (H2S) and mild hypothermia have been reported to prevent brain damage caused by reperfusion assault through regulating the N-methyl-D-aspartate receptor (NMDAR). However, relationship between two treatments how they exert neuro-protective effects NMDARs remain be elucidated.Transient cerebral ischemia was induced using Pulsinelli four-vessel occlusion method. We used sodium hydrosulphide (NaHS) as H2S donor. randomly divided 100 Sprague-Dawley rats into five groups of...
In security e-health brain neurosurgery, one of the important processes is to move electrocoagulation appropriate position in order excavate diseased tissue. 1 However, it has been problematic for surgeons freely operate electrocoagulation, as workspace very narrow brain. Due precision, vulnerability, and function tissues, essential ensure precision safety tissues surrounding part. The present study proposes use a robot-assisted tele-surgery system accomplish process. With aim achieve...
Abstract Using RefSeq annotations, most disease/trait-associated genetic variants identified by genome-wide association studies (GWAS) appear to be located within intronic or intergenic regions, which makes it difficult interpret their functions. We reassessed GWAS-Associated single-nucleotide polymorphisms (herein termed as GASs) for potential functionalities using integrative approaches. 8834 of 9184 “noncoding” GASs were have regulatory functionalities. As examples, 3 (rs3130320,...
Hematopoietic stem cells (HSCs), which are localized in the bone marrow of adult mammals, come from hematopoietic endothelium during embryonic stages. Although basic processes HSC generation and differentiation have been described past, epigenetic regulation hematopoiesis remains to be fully described. Here, by utilizing an vitro system mouse (ESCs), we identified more than 20 microRNAs that were highly enriched cells, including some (e.g. miR-10b, miR-15b, miR-27a) with previously unknown...
Two main subclasses of macrophages are found in almost all solid tissues: embryo-derived resident tissue and bone marrow-derived infiltrated macrophages. These macrophage subtypes show transcriptional functional divergence, the programs that have shaped evolution renal related signaling pathways remain poorly understood. To clarify these processes, we performed data analysis based on single-cell profiling tissue-resident human, mouse rat.In this study, (i) characterized divergence among...
The past two decades have witnessed the great growth of development novel drug carriers. However, releasing dynamics from carriers in vivo and interactions between cells remain unclear. In this paper, liposomes were prepared to encapsulate D-luciferin, which was substrate luciferase served as a model drug. Based on theoretical calculation active loading, methods preparation for optimized. Only when D-luciferin released or taken by could bioluminescence be produced under catalysis luciferase....
A physical model of soft tissue that provides realistic and real-time haptic visual feedback is crucial for neurosurgical procedures. This paper investigates the interaction between surgical instruments brain tissue, proposing a deformation simulation method based on principle energy minimization constrained function. The includes permanent function induced by friction volume preservation to more accurately depict response during procedures such as resection convex meningiomas evacuation...
Abstract Traditionally, teleoperation means that the system sends a series of signal commands from master while slave manipulator receives and realizes desired control operations. For purpose implementing more dexterous complex tasks, we propose novel framework with dual-hand systems under time-varied delays. In this paper, emphasize studying bilateral grasping control, as time delay causes communication outage. Combining wave-variable structure four-channel framework, an event-trigger-based...