A5015823931- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Acute Ischemic Stroke Management
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Functional Brain Connectivity Studies
- Venous Thromboembolism Diagnosis and Management
- Alzheimer's disease research and treatments
- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- AI in cancer detection
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Cardiovascular Disease and Adiposity
- Digital Radiography and Breast Imaging
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Cancer Cells and Metastasis
- Electronic Health Records Systems
Yinchuan First People's Hospital
2025
Capital Medical University
2015-2024
Yuhuangding Hospital
2014-2023
Qingdao University
2017-2023
Zunyi Medical University
2019-2023
Beijing Xuanwu Traditional Chinese Medicine Hospital
2008-2020
Ningbo First Hospital
2019
Shanghai Liangyou (China)
2017
Capital University
2006-2016
Tsinghua University
2008
Background Tenecteplase (TNK) possesses several pharmacological characteristics superior to conventional alteplase (rt-PA), with well-established safety and efficacy profile in Caucasians. There exists controversy over the optimal dose of intravenous rt-PA for East Asians acute ischaemic stroke (AIS). Current study aimed determine range recombinant human TNK tissue-type plasminogen activator (rhTNK-tPA) patients AIS China. Methods This multicentre, prospective, randomised, open-label,...
Radiomics has shown potential in disease diagnosis but the feasibility for non-small cell lung carcinoma (NSCLC) subtypes classification is unclear.This study aims to explore value of texture and colour features from Positron Emission Tomography Computed (PET-CT) images differentiation NSCLC subtypes: adenocarcinoma (ADC) squamous (SqCC).Two patient cohorts were retrospectively collected into a dataset 341 FDG PET-CT tumours (125 ADC, 174 SqCC 42 cases with unknown subtype).Quantification...
To detect diffuse myocardial fibrosis in different severity levels of left ventricular diastolic dysfunction (DD) spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys.Eighteen T2DM and nine healthy monkeys were studied. Echocardiography was performed for function classification. Cardiac magnetic resonance (CMR) imaging to obtain extracellular volume fraction (ECV) maps T1ρ at two spin-locking frequencies. ECV values, index (mFI) values which are based on the dispersion T1ρ, calculated....
Background With the proliferation of electronic medical record (EMR) systems, there is an increasing interest in utilizing EMR data for research; yet, no quantitative research on utilization purposes China. Objective This study aimed to understand how and what extent are utilized a Healthcare Information Management Systems Society (HIMSS) Analytics Electronic Medical Record Adoption Model (EMRAM) Stage 7 hospital Beijing, Obstacles issues were also explored provide foundation improved such...
Wetlands are the heart of oases in arid and semi-arid regions Northwest China, playing a crucial role climate regulation, water supply, flood storage drought prevention, biodiversity conservation, maintaining ecological stability areas. The extraction wetland information provides rapid accurate means for monitoring environment, biodiversity, preventing desertification land degradation. Taking Ningxia Yinchuan metropolitan area along Yellow River as study area, this research uses Sentinel-1...
A series of 2-arylbenzothiazole derivatives conjugated with bis(aminoethanethiol) (BAT) chelating groups were designed and synthesized. competitive binding assay-based screening was used to select seven rhenium complexes potent affinity toward Aβ1–42 aggregates (Ki < 50 nM) for 99mTc labeling further evaluation. The 99mTc-labeled probes showed good specificity Aβ plaques in Tg mouse brain tissue vitro autoradiography studies. Moreover, [99mTc]14b exhibited favorable pharmacokinetics normal...
Glucose metabolism reduction and brain volume losses are widely reported in Alzheimer's disease (AD). Considering that neuroimaging changes the hippocampus default mode network (DMN) promising important candidate biomarkers have been included research criteria for diagnosis of AD, it is hypothesized atrophy metabolic abovementioned regions could be evaluated concurrently to fully explore neural mechanisms underlying cognitive impairment AD. Twenty-three AD patients Twenty-four age-, sex-...
Abstract Background and purpose The recanalization rate after intravenous thrombolysis (IVT) is not enough there still the possibility of re-occlusion. We aim to investigate effectiveness safety infusing tirofiban IVT. Methods performed a prospective controlled study 60 patients with acute non-cardiogenic ischemic stroke who were hospitalized in Yantai Yuhuangding Hospital from January 2018 December 2019. divided into 2 groups: those received for 24 h IVT (rt-PA + T group) did receive...
This study aimed to discuss the pathogenesis, clinical manifestation, diagnosis, and treatment of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.The diagnosis 2 cases with teratoma-associated anti-NMDAR encephalitis were summarized data patients reported by domestic international studies reviewed in this study. The both adolescent females who showed mental abnormalities as their main manifestation. positive for antibody serum cerebrospinal fluid, gynecologic ultrasound detected...
Comorbid depression/anxiety in type 2 diabetes mellitus (DM) patients is highly prevalent, affecting both control and quality of life. However, the best treating method for DM still unclear. This study was conducted to compare efficacy paroxetine agomelatine on metabolic patients.A total 116 depressed, were recruited 12 weeks treatment. Patients randomly assigned receive either or agomelatine. Hamilton Depression Rating Scale Anxiety used assess depression anxiety, respectively. Hemoglobin...
This study aimed to demonstrate the function and molecular mechanism of protein regulator cytokinesis 1 (PRC1) in carcinogenesis non-small cell lung cancer (NSCLC).Bioinformatics analysis was performed. Cell culture plasmid construction were conducted for transfection. mRNA expression, proliferation, migration, cycle detected. Mice models also constructed. The relationship between PRC1 prognosis NSCLC patients analyzed.PRC1 expression higher tumor tissues than adjacent non-tumor (P<0.05)....
Three fluorinated (<sup>19</sup>F or <sup>18</sup>F) small molecules were evaluated as fluorescent radiolabeled probes for Aβ deposits in the brain.
Abstract Simultanagnosia is a common symptom of posterior cortical atrophy, and its association with brain structural functional changes remains unclear. In our study, 18 atrophy patients simultanagnosia, 29 Alzheimer’s disease 20 cognitively normal controls were recruited subjected to full neuropsychological evaluation, including simultanagnosia tests, resting-state MRI. The gray matter volume was assessed by voxel-based morphometry, while the intrinsic connectivity evaluated using reduced...
Spontaneous T2DM in rhesus monkeys manifests as isolated diastolic dysfunction the early stage of diabetic cardiomyopathy, similar to humans. Myocardial deformation measurements have emerged a superior way measure left ventricular (LV) function cardiac dysfunction, making it possible further evaluate early-stage LV spontaneous monkeys.Spontaneous with (T2DM-DD, n = 10) and corresponding nondiabetic healthy animals (ND, 9) were prospectively scanned for CMR study. Circumferential longitudinal...
An oligoethyleneoxy linker was introduced for conjugation between 99mTc/Re-bis(aminoethanethiol) (BAT) and β-amyloid (Aβ) binding scaffolds. Rhenium complexes exhibited high to moderate affinity Aβ1-42 aggregates efficient fluorescent staining Aβ plaques in brain tissue. After radiolabeling, the 99mTc-labeled probes revealed improved pharmacokinetics normal ICR mice. Probe [99mTc]15 with potent (Ki = 13.4 nM) highest initial uptake (2.10% ID/g at 2 min) mice evaluated further. In vitro...
Background: The diagnostic value of tumor markers in pleural effusion (PE) and serum for malignant (MPE) is still debate. This study aimed to evaluate the six PE, serum, corresponding PE/serum (PE/S) ratio distinguishing MPE from benign (BPE). Methods: A total 1,230 patients with PE (452 MPEs 778 BPEs) were retrospectively included study. levels carcinoembryonic antigen (CEA), carbohydrate 15-3 (CA15-3), 125 (CA125), 19-9 (CA19-9), cytokeratin 19 fragment (CYFRA 21-1), neuron-specific...
Objective The in vivo imaging of programmed death ligand 1 (PD-L1) can monitor changes PD-L1 expression and guide (PD-1) or PD-L1-targeted immune checkpoint therapy. A 99m Tc-labeled affibody molecular probe targeting the receptor was prepared evaluated its tracing effect PD-L1-overexpressing colon cancer. Methods by genetic recombineering. Tc labeling achieved sodium glucoheptonate an SnCl 2 system. rate, radiochemical purity, stability vitro were determined instant thin-layer...
To prepare a single-photon molecular probe easily labeled with 99m Tc for evaluating the expression status of human epidermal growth factor receptor 2 (HER2) in ovarian cancer.The HEHEHE tag was added to amino terminus affibody Z HER2:V2 by method gene recombinant expression, and new synthesized which easy be Tc. The newly prepared Tc, pharmacokinetic studies were carried out.A (HE) 3 recombination is labeling can reach about 95% at 90°C. study has shown that Tc-labeled fast clearance time...
The aim of this study was to investigate the effects mild hypothermia and minimally invasive evacuation hematoma on brain function patients with cerebral hemorrhage. Seventy-six acute hemorrhage were divided into (MIHE) (MHMIHE) groups. National Institutes Health Stroke Scale (NIHSS) scores day admission patient one, three seven days after procedure recorded. Perihematoma tissue morphology observed using hematoxylin eosin staining. Nuclear factor-κB (NF-κB) expression determined by...
Purpose The objective of this study was to investigate the accumulation 18 F-fluorodeoxyglucose ( F-FDG) in whole brain between Alzheimer’s disease (AD) with depressive (ADD) symptoms compared AD without (ADND) using positron emission tomography/magnetic resonance imaging (PET/MRI). Additionally, aimed explore associations among F-FDG brain, symptoms, and cognitive function ADD patients. Methods In study, 25 patients 22 healthy controls were enrolled. stratified into two groups, namely ADND,...