A5100451247- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Barrier Structure and Function Studies
- Kruppel-like factors research
- Acute Ischemic Stroke Management
- Nuclear Receptors and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Neuroblastoma Research and Treatments
- Ginkgo biloba and Cashew Applications
- Neurological disorders and treatments
- ATP Synthase and ATPases Research
- Polyomavirus and related diseases
- Metabolism, Diabetes, and Cancer
- Alcoholism and Thiamine Deficiency
- Cannabis and Cannabinoid Research
- Inflammation biomarkers and pathways
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- CNS Lymphoma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Cell death mechanisms and regulation
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Traumatic Brain Injury and Neurovascular Disturbances
- Apelin-related biomedical research
Institute of Animal Sciences
2025
Chinese Academy of Agricultural Sciences
2025
Soochow University
2013-2024
First Affiliated Hospital of Soochow University
2013-2024
Nantong University
2022-2024
Yancheng First People's Hospital
2023-2024
Liaoning University of Traditional Chinese Medicine
2024
Affiliated Hospital of Nantong University
2022
Yancheng Third People's Hospital
2022
Guangdong Provincial People's Hospital
2021
Tanshinone IIA (Tan-IIA) is the main bioactive component of Chinese herbal medicine salvia miltiorrhiza (Danshen). Sodium sulfonate Tan-IIA widely used in treatment cardiovascular and cerebrovascular diseases. also has inhibitory effects on tumor cells such as gastric cancer, but its therapeutic effect mechanism human neuroblastoma have not been evaluated, so pharmacological systematically evaluated by combined method network pharmacology molecular docking. PharmMapper SwissTargetPrediction...
Intracerebral hemorrhage (ICH) is a severe cerebrovascular disease with high morbidity and mortality rates. Oxidative stress inflammation are important pathological mechanisms of secondary brain injury (SBI) after ICH. Brain muscle Arnt-like protein 1 (BMAL1), which forms the core component circadian clock, was previously shown to be involved in many diseases participate oxidative inflammatory responses. However, role BMAL1 SBI following ICH unknown. In addition, treatments targeting miR-155...
Cognitive impairment in Parkinson's disease (PD) involves the cholinergic system and neurons, especially nucleus basalis of Meynert (NBM/Ch4) located basal forebrain (BF). We analyzed associations between NBM/Ch4 volume cortical thickness to determine whether NBM/Ch4-innervated neocortex shows parallel atrophy with as progresses PD patients cognitive (PD-MCI).We enrolled 35 PD-MCI patients, 48 normal cognition (PD-NC), 33 age- education-matched healthy controls (HCs), all participants...
Necroptosis-mediated cell death is an important mechanism in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI). Our previous study has demonstrated that receptor-interacting protein 1 (RIP1) mediated necroptosis SBI after ICH. However, further mechanisms, such as the roles of 3 (RIP3), mixed lineage kinase domain-like (MLKL), and Ca2+ /calmodulin-dependent II (CaMK II), remain unclear. We hypothesized RIP3, MLKL, CaMK might participate ICH, including their phosphorylation....
This study aimed to discuss the pathogenesis, clinical manifestation, diagnosis, and treatment of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.The diagnosis 2 cases with teratoma-associated anti-NMDAR encephalitis were summarized data patients reported by domestic international studies reviewed in this study. The both adolescent females who showed mental abnormalities as their main manifestation. positive for antibody serum cerebrospinal fluid, gynecologic ultrasound detected...
Abstract Aims Intracerebral hemorrhage (ICH) is a disease with high rates of disability and mortality. The role epidermal growth factor receptor 1 (ERBB1) in ICH was elucidated this study. Methods model constructed by injecting autologous arterial blood into the right basal ganglia. protein level ERBB1 detected western blot analysis. To up‐ downregulation rats, intraventricular injection lentivirus overexpression vector AG1478 (a specific inhibitor ERBB1) used. cell apoptosis, neuronal loss,...
The efficacy and safety of Tai-Kang-Ning (TKN) capsule, a traditional Chinese medicine formula, for the treatment acute heroin withdrawal syndrome were investigated by conducting double-blind, double-dummy, positive-controlled, randomized trial. Sixty-four patients with recruited. These treated either TKN or lofexidine in fixed schedule doses 10 days. results indicate that both treatments significantly reduced symptoms day 3, but there was no significant difference overall between safety....
Objective To investigate the effect of hemoglobin on structure and function blood-brain barrier (BBB) in rat models after intracerebral hemorrhage.Methods One hundred eight male SD rats were randomized into normal control group (n=12),intracerebral injection (Hb group,n=48) sham-operated (n=48); according to different observation time points,rats Hb divided 4 subgroups (6 24 h,3 7 d injection,n=1 2).Histological changes iron deposition brain tissues examined with HE staining...
<h3>Objectives</h3> Diabetic patients are known to have an independent risk of cardiomyopathy. Hyperglycemia leads upregulation reactive oxygen species (ROS) and inflammatory condition that may contribute diabetic There evidences the activation AMPK is playing pivotal role in lipid glucose metabolism. 2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygoni multiflori has been demonstrated possess a variety pharmacological activities, including antioxidant, anti-inflammatory...
Objective To explore the effects of hemoglobin level on Rho kinase Ⅱ endothelial cells and tight junction protein clandin-5 in blood-brain barrier (BBB) rats after intracerebral hemorrhage (ICH).Methods Male SD were randomized into normal control group (n=18) inducement (n=72); was divided 4 subgroups (24 48 h,and 3 7 d surgery,n=18).Rat ICH models established by injection brain tissues.The expression ofRho phosphorylated myosin light chain BBB observed immunohistochemical staining,and...
[Objective]To explore the distribution and expression changes of tight junctional protein JAM-1 in rat models after intracerebral hemorrhage (ICH) their significance.[Methods]One hundred twenty-eighty healthy male SD rats were randomly divided into normal control group (n=16) ICH (n=112),and induced by stereotactically injecting 75 uL autologous blood right caudate nucleus.Seven time points (6,12,24 48 h,and 3,7 14 d ICH,16 for each point) chosen.BBB permeability was evaluated Evans blue dye...
目的 探讨原发额骨套细胞淋巴瘤的临床特点、诊断、治疗方案和预后。 方法 回顾性分析莆田学院附属医院收治的1例原发额骨套细胞淋巴瘤患者的临床资料，并进行文献复习。 结果 该患者因头晕行影像学检查提示右侧额骨板障内类梭形细胞病变，嗜酸性肉芽肿，后经右额骨嗜酸性肉芽肿切除，病理检查明确诊断为套细胞淋巴瘤。一线使用CHOP方案化疗4个疗程。44个月后复发，二线予GEMOX方案化疗8个疗程后复查PET-CT提示完全缓解，后予沙利度胺维持治疗，患者维持无事件生存。 结论 原发额骨套细胞淋巴瘤临床上较罕见，发病率低，化疗效果较好。