A5100411899- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Biological and pharmacological studies of plants
- MicroRNA in disease regulation
- Plant Pathogens and Fungal Diseases
- Flavonoids in Medical Research
- Pharmacological Effects of Medicinal Plants
- Inflammatory mediators and NSAID effects
- Antibiotics Pharmacokinetics and Efficacy
- Treatment of Major Depression
- Mycobacterium research and diagnosis
- Medicinal Plants and Bioactive Compounds
- Cannabis and Cannabinoid Research
- RNA modifications and cancer
- Mycorrhizal Fungi and Plant Interactions
- Drug-Induced Adverse Reactions
- Pancreatic and Hepatic Oncology Research
- Fungal and yeast genetics research
- Coffee research and impacts
- Musculoskeletal pain and rehabilitation
- Gut microbiota and health
- Pain Management and Placebo Effect
- Plant biochemistry and biosynthesis
- Ginseng Biological Effects and Applications
- Bone Metabolism and Diseases
Czech Academy of Sciences, Institute of Microbiology
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
West China Hospital of Sichuan University
2010-2024
Sichuan University
2010-2024
China National Pharmaceutical Group Corporation (China)
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2023
Chongqing Academy of Chinese Materia Medica
2022-2023
Qiqihar University
2023
Institute of Chemistry
2023
Anqing City Hospital
2023
Mepolizumab is primarily used in the treatment of asthma, eosinophilic granulomatosis with polyangiitis, eosinophilia syndrome, and chronic rhinitis nasal polyps. The information about its adverse drug reactions mainly derived from clinical trials, there a shortage real-world studies extensive sample sizes. In this study, U.S. FDA’s Adverse Event Reporting System (FAERS) database was analyzed to evaluate side effects mepolizumab. A total 18,040 reports mepolizumab-associated events were...
Gemcitabine-based chemotherapy is the most common treatment option for pancreatic ductal adenocarcinoma (PDAC). However, it offers little therapeutic value in many cases due to rapid development of chemoresistance. MicroRNAs (miRNAs) have been found play pivotal roles chemotherapeutic resistance PDAC. We that miR-410-3p was significantly down-regulated human cancer xenograft (HPCx) tumor tissues from gemcitabine-treated mice. Low expression correlated with gemcitabine HPCx tumors and PDAC...
Cyclophosphamide (CTX) is a widely used chemotherapeutic agent for the treatment of malignant tumors and autoimmune diseases. However, it can cause immunosuppression damage intestinal mucosa. The development new agents to counteract these side effects becoming increasingly important. Previous studies have shown that polysaccharides from Gastrodia elata (GEPs) strong immune-enhancing effects; however, their functions regarding intestines underlying mechanism are still unclear. In this study,...
ABSTRACT Velvet transcription factors are found throughout the fungal kingdom and share a common velvet domain with fold similar to that of animal NF-κB. They act as homodimeric or heterodimeric master regulators secondary metabolism, development, differentiation. A comparison domains from 4,999 proteins revealed conserved overall architecture, including an N-terminal DNA-binding region approximately 30 amino acids C-terminal dimerization about 100 acids. The comprises α- β-subunits...
Background Insufficient apoptosis in activated lymphocytes contributes to the development of autoimmune hepatitis (AIH). Baicalein (BE), a flavonoid originally isolated from root Scutellaria baicalensis Georgi, possesses anti-inflammatory properties. However, whether BE can selectively induce and exert therapeutic effect on AIH has not been studied. Methodology/Principal Findings The pro-apoptotic properties were evaluated vitro different types immune cells, vivo effects examined murine...
Integration of various qualities excellent biocompatibility, improved mechanical properties, tailored biodegradation and functional bioactivities into a collagen-based hydrogel scaffold with all natural components, monitored by non-invasive MRI.
Abstract Background: Parkinson disease (PD), a progressive neurodegenerative disease, affects at least 1% of population above the age 65. Although specific etiology PD remains unclear, recently endogenous neurotoxins such as (R)-salsolinol [(R)-Sal] and N-methyl-(R)-salsolinol [(R)-NMSal] have been thought to play major role in PD. Much interest is focused on degeneration dopamine neurons induced by these neurotoxins. However, little literature available impact balance between (DA)...
Objectives: This study aims to investigate whether variations in LIPC, CETP, ABCA1 and LPL, which are involved high-density lipoprotein (HDL) metabolism, associated with advanced age-related macular degeneration (AMD) the Chinese population.Design Methods: A total of 119 patients AMD 99 control individuals were recruited. Genomic DNA was extracted from peripheral blood leukocytes. Genotypes seven single nucleotide polymorphisms (SNPs) including rs1061170 rs1410996 CFH, rs10490924 HTRA1,...
Previous studies indicated that single‐nucleotide polymorphisms ( SNP s) of genes coding for toll‐like receptors TLR and toll‐interacting protein TOLLIP ) may be involved in the pathogenesis pulmonary tuberculosis PTB ). This study was designed to investigate potential associations between 2 , 4 susceptibility latent infection LTBI or subsequent a Chinese Han population. A total 209 201 patients 204 healthy control subjects HCS were enrolled our study. We performed logistic regression...
Plant polyphenols, which contain phenolic acids such as chlorogenic acid (CGA), can be used for the treatment of gastrointestinal cancer and have gained increasing attention in recent years. In this study, we explored a novel CGA-containing herbal medicine named LASNB, was extracted from Lonicera japonica Thunb., Agrimonia eupatoria L., Scutellaria barbata D.Don.CGA LASNB analyzed using high-performance liquid chromatography (HPLC). The biological functions molecular mechanisms were...
The velvet family proteins have been shown to play critical roles in fungal secondary metabolism and development. However, variations of the observed different fungi. We report here observation on role three complex components VeA, VelB, LaeA Pestalotiopsis microspora, a formerly reported taxol-producing fungus. Deletion individual members led retardation vegetative growth sporulation pigmentation, suggesting these processes. mutant strain △velB appeared hypersensitive osmotic stress dye...
The efficacy and safety of Tai-Kang-Ning (TKN) capsule, a traditional Chinese medicine formula, for the treatment acute heroin withdrawal syndrome were investigated by conducting double-blind, double-dummy, positive-controlled, randomized trial. Sixty-four patients with recruited. These treated either TKN or lofexidine in fixed schedule doses 10 days. results indicate that both treatments significantly reduced symptoms day 3, but there was no significant difference overall between safety....
The canonical Gcn2/Cpc1 kinase in fungi coordinates the expression of target genes response to amino acid starvation. To investigate its possible role secondary metabolism, we characterized a gcn2 homolog taxol-producing fungus Pestalotiopsis microspora. Deletion gene led severe physiological defects under starvation, suggesting conserved function sensing. mutant strain △gcn2 displayed retardation vegetative growth. It generated dramatically fewer conidia, connection between metabolism and...
Reverse genetics is a promising strategy for elucidating the regulatory mechanisms involved in secondary metabolism and development fungi. Previous studies have demonstrated key role of histone acetyltransferases transcriptional regulation. Here, we identified MYST family acetyltransferase encoding gene, mst2, filamentous fungus Pestalotiopsis microspora NK17 revealed its metabolism. The gene mst2 showed temporal expression that corresponded to conidiation process wild-type strain. Deletion...
Maitake (Grifola frondosa) is an edible mushroom exhibiting high nutritional value in terms of containing health-beneficial bioactive compounds. Previously, we reported that a protein-bound polysaccharide component G. frondosa (PGM) could enhance the expression α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR), which critical for learning and memory. However, potential benefits PGM on memory function have never been investigated. In current study, aimed to explore...