A5077001501- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Monoclonal and Polyclonal Antibodies Research
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Power Systems and Technologies
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- interferon and immune responses
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Growth Hormone and Insulin-like Growth Factors
- Ubiquitin and proteasome pathways
- Mesenchymal stem cell research
- Biosimilars and Bioanalytical Methods
Lanzhou University
2015-2025
First Hospital of Lanzhou University
2014-2025
Hebei Medical University
2024-2025
Fourth Hospital of Hebei Medical University
2024-2025
Sichuan University
2012-2024
West China Hospital of Sichuan University
2022-2024
Nanjing University of Science and Technology
2021-2023
Fifth Tianjin Central Hospital
2022-2023
Chinese PLA General Hospital
2023
First Affiliated Hospital of Xinjiang Medical University
2022
Lactate dehydrogenase A (LDH-A) is a key enzyme during glycolysis, which increases the synthesis of related proteins and has elevated activity in cancer cells. The role LDH-A lung adenocarcinoma (LUAD) progression was investigated present study. Expression levels were assessed LUAD samples, relationship between expression status prognosis patients confirmed. effect on proliferation, invasion, migration, colony formation cells assessed. We further determined tumor growth vivo by using...
PURPOSE This study aimed to evaluate the safety and efficacy of ivonescimab (a bispecific antibody against programmed death-1 [PD-1] vascular endothelial growth factor [VEGF]) as first- or second-line monotherapy in advanced immunotherapy naïve non-small-cell lung cancer (NSCLC) patients. METHODS Eligible patients received intravenous 10mg/kg every 3 weeks (Q3W), 20 mg/kg 2 (Q2W), Q3W 30mg/kg Q3W. The primary endpoints were objective response rate (ORR) per RECIST v1.1. RESULTS At data...
Abstract Immunotherapy exhibits considerable promise for sustained tumor reduction. However, current cancer immunotherapy methods elicit limited responses due to the inadequate immunogenicity exhibited by cells. This obstacle may be addressed using nanoplatforms that can activate synergistic therapies (photodynamic therapy and ferroptosis) in response acidic pH of microenvironment. We previously developed an amphiphilic photosensitizer, SR780, which displays satisfactory photodynamic...
Background: To date, the pathogenesis of gastric cancer (GC) remains unclear.We combined public database resources and bioinformatics analysis methods, explored some novel genes verified experiments to further understand GC provide a promising target for anti-tumor therapy. Methods:We downloaded chip data related from Gene Expression Omnibus (GEO) database, extracted differentially expressed (DEGs), then determined key in development via PPI networks model analysis.Functional annotation GO...
440 Background: Approximately 12–23% G/GEJC patients have human epidermal growth factor receptor 2 (HER2)-positive disease. Despite survival benefit from combination therapy with trastuzumab and chemotherapy, the prognosis remains unsatisfactory; more effective treatments are needed. This phase study is evaluating of HLX22 (an anti-HER2 monoclonal antibody targeting a different epitope than trastuzumab), trastuzumab, XELOX chemotherapy as first-line treatment for advanced/metastatic G/GEJC....
Combining nanomedicine with immunotherapy offers a promising and potent cancer treatment strategy; however, improving the effectiveness of antitumor immune response remains challenging. A "cold" tumor microenvironment (TME) is marked factor affecting efficacy immunotherapy. Herein, intracellular-acidity-activatable dynamic nanoparticles (NPs) were designed for precision photodynamic ferroptosis in cancer. M1 macrophage-derived exosomes (Mex) constructed to coassemble photosensitizer SR780,...
To explore the early changes in various liver function indicators critically injured trauma patients assessed by intelligent calculation method, aiming to develop more advantageous diagnostic and treatment strategies for traumatic injury. A retrospective study was conducted. Critically [injury severity score (ISS) ≥ 16, age > 18 years old] admitted Emergency Medical Center of Tianjin Fifth Central Hospital from January 1, 2022, December 2023 were enrolled. ISS acute physiology chronic health...
The therapeutic effects of conventional treatments for advanced colorectal cancer with peritoneal carcinomatosis (CRPC) and malignant ascites are not very encouraging. Vascular endothelial growth factor-A/vascular permeability factors (VEGF-A/VPF) play key roles in the formation ascites. In previous work, we demonstrated that pigment epithelium-derived factor (PEDF) antagonized VEGF-A could repress tumor suppress metastasis several types. Thus, PEDF may be a candidate treating Mesenchymal...
Insulin plays an important role in regulation of lipid and glucose metabolism. Retinoic acid receptor‐related orphan receptor α (RORα) modulates physiopathological processes such as dyslipidemia diabetes. In this study, we found overexpression RORα INS1 cells resulted increased expression secretion insulin. Suppression endogenous caused a decrease insulin expression. Luciferase electrophoretic mobility shift assay (EMSA) assays demonstrated that activated transcription via direct binding to...
The availability of intracellular, stabilized β-catenin, a transcription factor coactivator, is tightly regulated; β-catenin translocated into the nucleus in response to Wnt ligand binding its cell membrane receptors. Here we show that signal activation mammalian cells activates intracellular mobilization connexin 43 (Cx43), which belongs gap junction protein family, new target extracellular activation. Transmission electron microscopy showed nuclear localization Cx43 was increased by 8-...
Background Adiponectin is reported to be related the development of chronic obstructive pulmonary disease (COPD). Genetic variants in gene encoding adiponectin (ADIPOQ) have been associated with level several genome–wide linkage and association studies. However, relatively little known about effects ADIPOQ on COPD susceptibility. We determined frequencies single-nucleotide polymorphisms (SNPs) a Chinese Han population their possible Methods conducted case–control study 279 patients 367 age-...