A5100711559- Bone Metabolism and Diseases
- dental development and anomalies
- Orthodontics and Dentofacial Orthopedics
- Epigenetics and DNA Methylation
- Retinal Development and Disorders
- Dental Implant Techniques and Outcomes
- Temporomandibular Joint Disorders
- TGF-β signaling in diseases
- Oral microbiology and periodontitis research
- Genomics and Chromatin Dynamics
- Axon Guidance and Neuronal Signaling
- Connective tissue disorders research
- RNA modifications and cancer
- Bone and Dental Protein Studies
- Cleft Lip and Palate Research
- S100 Proteins and Annexins
- Obstructive Sleep Apnea Research
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Craniofacial Disorders and Treatments
- Retinal Diseases and Treatments
- Wnt/β-catenin signaling in development and cancer
- Bone health and osteoporosis research
- Tracheal and airway disorders
- CRISPR and Genetic Engineering
Jilin University
2016-2025
Shanghai East Hospital
2025
Yunnan University
2023-2025
Second People's Hospital of Yunnan Province
2009-2025
Jilin Medical University
2013-2024
Hangzhou Medical College
2024
Stomatology Hospital
2010-2022
First Affiliated Hospital of Xiamen University
2021
Shanghai Jiao Tong University
2019-2020
Kunming University
2020
Cellular identity and differentiation are determined by epigenetic programs. The characteristics of these programs in normal human mammary epithelium their similarity to those stem cells unknown. To begin investigating issues, we analyzed the DNA methylation gene expression profiles distinct subpopulations epithelial using MSDK (methylation-specific digital karyotyping) SAGE (serial analysis expression). We identified discrete cell-type state-specific patterns that were maintained a subset...
SETDB1 is a histone H3K9 methyltransferase that has critical role in early development. It located within melanoma susceptibility locus and facilitates formation. However, the mechanism by which regulates tumorigenesis remains unknown. Here we report molecular interplay between well-known hotspot gain-of-function (GOF) TP53 R249S mutation. We show hepatocellular carcinoma (HCC) overexpressed with moderate copy number gain, GOF mutations including associate this overexpression. Inactivation...
Abstract Extracellular elastin‐derived peptides (EDPs) accumulate in the aging brain and have been associated with vascular dementia Alzheimer's disease (AD). The activation of inflammatory processes glial cells EDP treatment has received attention, but not neurons. To properly understand EDPs' pathogenic significance, impact on neuronal function neuron–microglia crosstalk was explored further. Among molecules, Val‐Gly‐Val‐Ala‐Pro‐Gly (VGVAPG) is a typical repeating hexapeptide. Here, we...
Abstract Histone lysine methyltransferase NSD2 (WHSC1/MMSET) is overexpressed frequently in multiple myeloma due to the t(4;14) translocation associated with 15% 20% of cases this disease. has been found be involved myelomagenesis, suggesting it may offer a novel therapeutic target. Here we show that activity crucial for clonogenicity, adherence, and proliferation cells on bone marrow stroma vitro required tumorigenesis t(4;14)+ but not t(4;14)− vivo. The PHD domains were important its...
The craniofacial skeleton is a complex and unique structure. perturbation of its development can lead to dysmorphology associated morbidities. Our ability prevent or mitigate skeletal anomalies at least partly dependent on our understanding the physiological skeleton. Mouse models are critical tools for study developmental abnormalities. However, there lack detailed normative data mouse in literature. In this report, we employed high-resolution micro-computed tomography (μCT) combination...
Abstract Psoriasin (S100A7) was identifi`ed as a gene highly expressed in psoriatic keratinocytes and more frequently ductal carcinoma situ (DCIS) than invasive breast carcinomas (IBC), suggesting potential role tumor progression. expression is associated with poor prognostic factors both DCIS IBC. Several putative functions have been proposed for psoriasin various disease types, but none of these can fully explain its involvement Here, we show that down-regulation endogenous via stable...
Osteoporosis is a metabolic disease characterized by reduced osteoblast differentiation and proliferation.Oxidative stress plays role in the pathogenesis of osteoporosis.Aucubin (AU), an iridoid glycoside, was previously shown to promote differentiation.We investigated effects AU on MG63 human osteoblast-like cells treated with dexamethasone (Dex) or hydrogen peroxide (H 2 O ) induce oxidative damage.AU protected against apoptosis, promoted increased expression cytokines associated...
The N-terminal tails of core histones harbor the sites numerous post-translational modifications (PTMs) with important roles in regulation chromatin structure and function. Profiling histone PTM marks provides data that help understand epigenetics events cells their connections cancer other diseases. Our previous study demonstrated specific derivatization peptides by NHS propionate significantly improved chromatographic performance on reversed phase columns for LC/MS analysis. As a step...
Histone modifications play a critical role In the pathological processes of dilated cardiomyopathy (DCM), while and expression pattern histone methyltransferases (HMTs), especially mixed lineage leukemia (MLL) families, in DCM are unclear. To this end, 12 normal 15 heart samples were included present study. A murine cardiac remodeling model was induced by transverse aortic constriction (TAC). Real-time polymerase chain reaction performed to detect levels MLL families mouse human left...
Abstract Background Diabetic retinopathy (DR) is a common diabetic neurodegenerative disease that affects vision in severe cases. Current therapeutic drugs are ineffective for some patients with side effects, and ginsenoside-Rg1 (GRg1) has been shown to protect against DR may serve as new potential drug DR. This study aimed confirm the protective effect of GRg1 its molecular mechanism. Methods Human retinal microvascular endothelial cells (hRMECs) rats were used construct models vitro vivo....
Histones participate in epigenetic regulation via a variety of dynamic posttranslational modifications (PTMs) on them. Mass spectrometry (MS) has become powerful tool to investigate histone PTMs. With the bottom-up mass approach, chemical derivatization histones with propionic anhydride or deuterated acetic followed by trypsin digestion was widely used block hydrophilic lysine residues and generate compatible peptides for LC-MS analysis. However, certain severe side reactions (such as...
To investigating whether osteogenic differentiation of osteoblasts promoted by tension force (TF) is mediated ephrinB2-EphB4 signaling. TF was applied to MC3T3-E1 cells, then CCK-8 and live/dead staining were used detect cell proliferation. Levels differentiation-related factors detected ALP staining, ARS qPCR western blot. NVP-BHG712 block EphB4 receptor. Establishing a rat orthodontic tooth movement (OTM) model, ephrinB2-Fc treat rats. Micro-CT H&E alveolar bone. Changes MAPK pathways...