A5100627872- Herpesvirus Infections and Treatments
- Plant Molecular Biology Research
- Andrographolide Research and Applications
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Pain Mechanisms and Treatments
- Plant Reproductive Biology
- Plant Stress Responses and Tolerance
- Botulinum Toxin and Related Neurological Disorders
- Acne and Rosacea Treatments and Effects
- Photosynthetic Processes and Mechanisms
- Healthcare and Venom Research
- Heart Rate Variability and Autonomic Control
- Leprosy Research and Treatment
- Plant responses to water stress
- Phytochemistry and Biological Activities
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Electromagnetic Fields and Biological Effects
- Legume Nitrogen Fixing Symbiosis
- Traditional Chinese Medicine Studies
- Immune Response and Inflammation
- Plant nutrient uptake and metabolism
- Olfactory and Sensory Function Studies
Nanchang University
2016-2025
First Affiliated Hospital of Nanchang University
2016-2025
Nanjing University
2025
Jiangxi Mental Health Center
2025
Hangzhou Medical College
2020-2024
Xinjiang Agricultural University
2016-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Jiangsu University of Science and Technology
2023
Hebei Agricultural University
2023
Jiangxi Provincial Academy of Medical Sciences
2023
Significance In flowering plants, pollen tubes deliver paired sperm cells into ovules for double fertilization by perceiving and responding to multiple attractants secreted from the ovules. Ca 2+ gradients in tube tips are essential guidance, plasma membrane channels core components regulation of mediating regulating external influx. Therefore, guidance. However, molecular identities remain be addressed. this research, we found that cyclic nucleotide-gated channel 18, out eight present...
Background:Phellinus igniarius (P. igniarius) is an important medicinal and edible fungus in China other Southeast Asian countries has diverse biological activities. This study was performed to comparatively investigate the therapeutic effects of wild cultivated P. on hyperuricaemia gouty arthritis rat models. Methods: UPLC-ESI-qTOF-MS used identify chemical constituents polyphenols from (WPP) (CPP). Furthermore, WPP CPP were evaluated improved model induced by yeast extract, adenine...
To investigate the presence of modular loss coupling and abnormal alterations in functional structural networks brain patients with postherpetic neuralgia (PHN). We collected resting-state magnetic resonance imaging data diffusion tensor from 82 healthy controls (HCs) 71 PHN patients, generated connectivity (SC) (FC) networks, assessed corresponding clinical information assessment. Based on AAL(90) mapping, network was divided into 9 modules, structural–functional (SC–FC) compared at...
Purpose: In this study, we aim to explore the changes in network graph theory indices of structural covariance networks (SCNs) PHN patients with different disease durations. Patients and Methods: High-resolution T1 magnetic resonance images were collected from 109 subjects. We constructed SCNs based on cortical thickness data analyzed global regional measures herpes zoster (HZ) patients, get hubs each group. Results: (1) a duration > 6 months had reduced efficiency (P=0.035) increased...
The aim of this study was to explore the amplitude intrinsic low-frequency oscillations (LFOs) in patients with discogenic low-back and leg pain (LBLP).We obtained compared LFO from 25 right-handed LBLP (13 males; mean age 55.16±1.83 years) 27 well-matched healthy controls (15 52.96±1.63 years). examined using voxel-wise fluctuations (ALFFs), partial correlation analysis performed determine relationship between regions altered ALFF values clinical parameters patients.Compared controls,...
The genetic identities of Ca2+ channels in root hair (RH) tips essential for constitutive RH growth have remained elusive decades. Here, we report the identification and characterization three cyclic nucleotide-gated channel (CNGC) family members, CNGC5, CNGC6, CNGC9, as Arabidopsis. We found that cngc5-1cngc6-2cngc9-1 triple mutant (designated shrh1) showed significantly shorter branching phenotypes compared with wild type. defective phenotype shrh1 could be rescued by either expression or...
Sepsis-associated encephalopathy (SAE) occurs in sepsis survivors and is associated with breakdown of the blood–brain barrier (BBB), brain inflammation, neurological dysfunction. We have previously identified a group extracellular microRNAs (ex-miRNAs), such as miR-146a-5p, that were upregulated plasma septic mice human, capable inducing potent pro-inflammatory cytokines complements. Here, we established clinically relevant mouse model SAE investigated role miRNAs their sensor Toll-like...
Summary Recent studies on co-transformation of the growth regulator, TaGRF4-GIF1 chimera ( Growth Regulating Factor 4-GRF Interacting 1 ), in cultivated wheat varieties Triticum aestivum showed improved regeneration efficiency, marking a significant breakthrough. Here, simple and reproducible protocol using GRF4-GIF1 was established tested medicinal orchid Dendrobium catenatum , monocot species. from T. DcGRF4-GIF1 D. were reconstructed, with chimeras significantly enhancing efficiency...
Recent studies mentioned that Andrographolide (Andro), the main bioactive component of traditional Chinese medicine Andrographis paniculata, may be a potential natural product for treating Alzheimer's disease, but underlining mechanism remains to discovered. In this study, we investigated whether Andro regulates nuclear factor E2-related 2 (Nrf2)/Sequestosome 1 (p62) signaling pathway and activates autophagy protect neuronal PC12 cells from toxicity β-amyloid (Aβ) peptide. Our results...
TLR7 (Toll-like receptor 7), the sensor for single-stranded RNA, contributes to systemic inflammation and mortality in murine polymicrobial sepsis. Recent studies show that extracellular miR-146a-5p serves as a ligand plays an important role regulating host innate immunity. However, of signaling pulmonary inflammation, endothelial activation, sepsis-associated acute respiratory distress syndrome remains unclear. Here, we intratracheal administration exogenous mice evokes lung activates...
Although the functional roles of zinc finger-containing glycine-rich RNA-binding proteins (RZs) have been characterized in several plant species, including Arabidopsis thaliana and rice (Oryza sativa), physiological functions RZs wheat (Triticum aestivum) remain largely unknown. Here, three RZ family members, named TaRZ1, TaRZ2, TaRZ3, were investigated using transgenic plants under various abiotic stress conditions. Expression TaRZs was markedly regulated by salt, dehydration, or cold...
Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Sepsis remains a critical illness with high mortality. The authors have recently reported that mouse plasma RNA concentrations are markedly increased during sepsis and closely associated its severity. Toll-like receptor 7, originally identified as the sensor for single-stranded virus, also mediates host extracellular RNA-induced innate immune responses in vitro vivo . Here, hypothesize...
Objective: The aim of this study was to explore interhemispheric intrinsic connectivity in patients with postherpetic neuralgia (PHN). Methods: We obtained resting-state functional magnetic resonance imaging data from 18 right-handed PHN (11 males, 7 females; mean age, 59.67±8.41 years) and well-matched healthy controls 38.50±7.51 years). Interhemispheric examined using voxel-mirrored homotopic (VMHC), seed-based analysis performed. Results: Compared the controls, showed abnormally decreased...
Oxymatrine (OMT) often used in treatment for chronic hepatitis B virus infection clinic. However, OMT-induced liver injury has been reported. In this study, we aim to investigate the possible mechanism of hepatotoxicity human normal cells (L02). Exposed OMT, cell viability was decreased and apoptosis rate increased, intracellular markers oxidative stress were changed. Simultaneously, OMT altered apoptotic related proteins levels, including Bcl-2, Bax pro-caspase-8/-9/-3. addition, enhanced...
The aim of this study was to measure brain alterations in patients with herpes zoster (HZ) and postherpetic neuralgia (PHN) compare their differences using a voxel-based morphometry (VBM) technique.Thirty-three HZ, 22 PHN, 28 well-matched healthy controls (HCs) were recruited. Magnetic resonance imaging data acquired for all subjects analyzed the VBM method. changes gray matter volume (GMV) HZ PHN groups compared those HC group, GMV also between groups. Further correlation analysis receiver...
To measure the changes in cerebral cortical thickness patients with herpes zoster (HZ) and postherpetic neuralgia (PHN) by surface-based morphometry (SBM) further estimate its correlation clinical scores.Twenty-nine HZ patients, 30 PHN well-matched healthy controls (HCs) were included. Magnetic resonance imaging (MRI) data from all subjects collected then analyzed SBM. The among HZ, HC groups ANOVA correlated scores.The of bilateral primary visual cortex (V1, V2) right (V3), left...
Schizophyllum commune, a Basidiomycota fungus with tetrapolar mating system, serves as key model for studying sexual reproduction. In this study, two distinct subtypes (I and II) were identified in strain 20R-7-ZF01, isolated from subseafloor sediment, which exhibited eight different interaction phenotypes. Intra-subtypes colony-symmetric interactions (G1), whereas inter-subtype crosses yielded colony-asymmetric phenotypes (G2) reduced number of fruiting bodies. Nuclear migration analysis...
Background: Postherpetic neuralgia (PHN) causes chronic pain and emotional dysfunction, but its underlying mechanisms are unknown. Methods: We first compared the structural functional magnetic resonance imaging (MRI) of PHN-anxiety patients with healthy controls (HCs). Then, we created a PHN comorbid anxiety-like model by injecting resiniferatoxin (RTX) intraperitoneally used Fos-CreER::Ai9 mice to validate brain regions volume differences in MRI. Furthermore, combined behavioral experiments...
Purpose: Postherpetic neuralgia (PHN) detrimentally affects brain function. Recent studies have suggested that frequency-dependent changes in electroencephalography chronic pain patients and blood oxygenation level dependent (BOLD) fluctuations can reflect neuronal activity different frequencies. The current study aimed to investigate PHN-related oscillatory a specific frequency band by using the amplitude of low-frequency fluctuation (ALFF) method. Materials methods: ALFF were analyzed...