A5005199865- Congenital gastrointestinal and neural anomalies
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Dementia and Cognitive Impairment Research
- Appendicitis Diagnosis and Management
- Esophageal and GI Pathology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Intestinal Malrotation and Obstruction Disorders
- Urological Disorders and Treatments
- Lung Cancer Diagnosis and Treatment
- Infant Nutrition and Health
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Function and Risk Factors
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Neonatal Respiratory Health Research
- Health disparities and outcomes
- Hernia repair and management
- Intraperitoneal and Appendiceal Malignancies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Glaucoma and retinal disorders
- Sleep and related disorders
- Pneumonia and Respiratory Infections
- Animal Virus Infections Studies
Capital Medical University
2017-2025
Chongqing Medical University
2021-2025
Children's Hospital of Chongqing Medical University
2021-2025
National Clinical Research
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Beijing Children’s Hospital
2021-2025
Shuguang Hospital
2025
Shanghai University of Traditional Chinese Medicine
2025
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
The prevalence of depressive symptoms among older adults has become an increasingly important public health priority. Elevated are well documented elderly people with cardiovascular disease (CVD), but studies conducted Chinese scarce.To estimate the association between and incident CVD middle-aged adults.The China Health Retirement Longitudinal Study is ongoing nationally representative prospective cohort study that was initiated in 2011. This included 12 417 without heart stroke at...
In the context of neuro-pathological disorders, neuroimaging has been widely accepted as a clinical tool for diagnosing patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). The advanced deep learning method, novel brain imaging technique, was applied in this study to evaluate its contribution improving diagnostic accuracy AD. Three-dimensional convolutional neural networks (3D-CNNs) were magnetic resonance (MRI) execute binary ternary classification models. dataset...
Lactate produced during ischemia-reperfusion injury is known to promote lactylation of proteins, which play controversial roles. By analyzing the lactylomes and proteomes mouse myocardium using mass spectrometry, we show that both Serpina3k protein expression its at lysine 351 are increased upon reperfusion. Both human homolog, SERPINA3, abundantly expressed in cardiac fibroblasts, but not cardiomyocytes. Biochemically, enhances stability. Using knockout mice overexpressing...
Abstract Background Associations between the frequency of social and intellectual activities cognitive trajectories are understudied in Chinese middle-aged older adults. We aimed to examine this association a nationally representative longitudinal study. Methods The China Health Retirement Longitudinal Study (CHARLS) is sample participants. was measured at baseline. Interview-based assessments orientation attention, episodic memory, visuospatial skills calculation combined global scores were...
Tuberculosis (TB) is still one of the most serious infectious diseases in mainland China. So it was urgent for formulation more effective measures to prevent and control it. The data reported TB cases 340 prefectures from China were extracted Information System Disease Control Prevention (CISDCP) during January 2005 December 2015. Kulldorff’s retrospective space-time scan statistics used identify temporal, spatial spatio-temporal clusters by using discrete Poisson probability model....
With the development of assisted reproductive technology (ART) and its increasing success rate in mainland China, more attention has been paid to safety ART. In this study, we explored associations between conception by ART pregnancy/perinatal complications, neonatal outcomes compared with similar following spontaneous conception.This retrospective cohort study pregnancies over a 3-year period (2013-2015) was performed at Beijing Obstetrics Gynecology Hospital, Beijing, China. Subjects were...
Background Cognitive impairment may increase the risk of all-cause and cardiovascular disease ( CVD ) mortality. This study examined association between cognitive function mortality among elderly in Beijing, China. Methods Results A total 1996 participants aged ≥55 years at baseline were enrolled from BLSA (Beijing Longitudinal Study Aging). was assessed using Mini-Mental State Examination MMSE ), categorized as: <18, 18 to 23, 24 27, 28 30. Cox proportional hazard models used estimate...
Lung cancer screening using computed tomography (CT) has increased the detection rate of small pulmonary nodules and early-stage lung adenocarcinoma. It would be clinically meaningful to accurate assessment nodule histology by CT scans with advanced deep learning algorithms. However, recent studies mainly focus on predicting benign malignant nodules, lacking model for risk stratification invasive We propose an ensemble multi-view 3D convolutional neural network (EMV-3D-CNN) study include...
The incidence of tuberculosis (TB) remains high worldwide. Current strategies will not eradicate TB by 2035; instead, 2182 is more likely. Therefore, it urgent that new risk factors be identified.An ecological study was conducted in 340 prefectures China from 2005 to 2015. spatial distribution shown clustering and hotspot analysis. relationship between the patterns six meteorological evaluated geographically weighted regression (GWR) model.During 11 years period, persistently low east west....
To determine the effectiveness of hemoglobin A1c (HbA1c) ≥ 6.5% in diagnosing diabetes compared to fasting plasma glucose (FPG) 126 mg/dL and 2-hour (2hPG) 200 a previously undiagnosed diabetic cohort, we included 5,764 adult subjects without established for whom HbA1c, FPG, 2hPG, BMI measurements were collected. Compared FPG criterion, sensitivity HbA1c was only 43.3% (106 subjects). 2hPG 28.1% (110 Patients who using criterion but had < more likely be older (<mml:math...
Radiomics has shown potential in disease diagnosis but the feasibility for non-small cell lung carcinoma (NSCLC) subtypes classification is unclear.This study aims to explore value of texture and colour features from Positron Emission Tomography Computed (PET-CT) images differentiation NSCLC subtypes: adenocarcinoma (ADC) squamous (SqCC).Two patient cohorts were retrospectively collected into a dataset 341 FDG PET-CT tumours (125 ADC, 174 SqCC 42 cases with unknown subtype).Quantification...
Purpose: This study assessed the influences of different lifestyle on mild cognitive impairment (MCI) progression and established a decision tree prediction model to analyse their predictive significance MCI incidence. Patients Methods: From October 2015 February 2020,330 patients with were recruited, demographic information collected. They followed up for 19.04 ± 10.227 months. Cognitive function was using Mini-Mental State Examination Scale every 6 months, they divided into stable group...
Abstract Background Despite research efforts, the causative factors that contribute to esophageal squamous cell carcinoma (ESCC) in high-risk areas have not yet been understood. In this study, we, therefore, aimed describe risk associated with ESCC and its precursor lesions. Methods We performed an endoscopic examination of 44,857 individuals aged 40–69 years from five high incidence regions China 2017–2018. Participants were classified as 4 groups normal control, esophagitis, low-grade...
Non-alcoholic fatty liver disease (NAFLD) is the most common disease. The mechanism by which bisphenol A (BPA) promots NAFLD remains unclear. Palmitic acid (PA) and lipopolysaccharide (LPS) were used to simulate in HepG2 cells vitro. Total cholesterol (TC), triglyceride (TG) content, lipid accumulation measured evaluate metabolism. caspase-1-stained NLRP3 inflammasome-associated proteins evaluated for pyroptosis. Western blot analysis was detect protein levels co-immunoprecipitation (Co-IP)...
Abstract Background No reliably specific method for complicated appendicitis has been identified in children younger than five years of age. This study aimed to analyze the independent factors age, develop and validate a prediction model differentiation simple appendicitis. Methods A retrospective 382 age with acute from January 2007 December 2016 was conducted assessments demographic data, clinical symptoms signs, pre-operative laboratory results. According intraoperative findings...
Synovial mesenchymal stem cells (SMSCs) have been discussed as promising tools for protecting chondrocytes from loss and inhibiting osteoarthritis (OA). This work infocuses on the function of SMSC-derived extracellular vesicles (EVs) in during OA molecular mechanism.EVs were extracted SMSCs identified. Chondrocytes treated with interleukin (IL)-1β to induce an OA-like condition vitro then EVs. The proliferation, apoptosis, migration, matrix (ECM) degradation inflammation examined. Key...
Abstract Purpose It has been shown that abnormalities of coagulation and fibrinolysis system are involved in the pathogenesis necrotizing enterocolitis (NEC), but not well studied challenge context early detection disease progression. The present study mainly explores predictive significance parameters at time NEC diagnosis identifying patients who eventually received surgery and/or NEC-related deaths. Methods retrospective 114 neonates with was conducted assessments demographic data,...
Background and Objectives: Lung cancer remains a leading cause of mortality worldwide. Accurately classifying benign pulmonary nodules malignant ones is crucial for early diagnosis improved patient outcomes. The purpose this study to explore the deep-learning model ResNet combined with convolutional block attention module (CBAM) differentiation between lung cancer, based on computed tomography (CT) images, morphological features, clinical information. Methods materials: In study, 8241 CT...