A5087922368- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Iron and Steelmaking Processes
- Metallurgical Processes and Thermodynamics
- Control Systems and Identification
- Immunotherapy and Immune Responses
- Advanced Control Systems Optimization
- Hepatitis Viruses Studies and Epidemiology
- Trace Elements in Health
- Viral gastroenteritis research and epidemiology
- COVID-19 diagnosis using AI
- Autophagy in Disease and Therapy
- Industrial Gas Emission Control
- Thermochemical Biomass Conversion Processes
- Functional Brain Connectivity Studies
- High Entropy Alloys Studies
- Coal and Coke Industries Research
- Metal Extraction and Bioleaching
- Catalytic Processes in Materials Science
- Coal Properties and Utilization
Beijing YouAn Hospital
2016-2025
Capital Medical University
2016-2025
Guizhou University
2024
University of Science and Technology Beijing
2019-2024
Second Affiliated Hospital of Dalian Medical University
2024
Beijing Intelligent Entropy Science & Technology Co. Ltd.
2024
University of Groningen
2023-2024
Lehigh University
2024
Capital University
2023
Baogang Group (China)
2005-2021
A coronavirus (HCoV-19) has caused the novel disease (COVID-19) outbreak in Wuhan, China. Preventing and reversing cytokine storm may be key to save patients with severe COVID-19 pneumonia. Mesenchymal stem cells (MSCs) have been shown possess a comprehensive powerful immunomodulatory function. This study aims investigate whether MSC transplantation improves outcome of 7 enrolled pneumonia Beijing YouAn Hospital, China, from Jan 23, 2020 Feb 16, 2020. The clinical outcomes, as well changes...
BACKGROUND. Identifying immune correlates of COVID-19 disease severity is an urgent need for clinical management, vaccine evaluation, and drug development. Here, we present a temporal analysis key mediators, cytokines, chemokines in blood hospitalized patients from serial sampling follow-up over 4 weeks.
A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe develops a small minority of infected individuals. In article, we report that homozygosity for C allele rs12252 interferon-induced transmembrane protein 3 (IFITM3) gene associated with more an age-dependent manner. This supports role IFITM3 pathogenesis and opportunity early targeted intervention at-risk
Abstract The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics pathological features underlying remain largely unknown. To characterize mechanisms pathogenesis in lung tissue using proteomic approach, fresh tissues were obtained from newly deceased patients pneumonia. After virus inactivation, quantitative approach combined bioinformatics analysis was used detect changes...
SARS-CoV-2 infection and its subsequent cytokine storm are the main causes of acute respiratory distress syndrome (ARDS) lung fibrosis. We investigate whether any inflammatory molecules could be related to fibrosis in COVID-19. Seventy-six COVID-19 patients admitted recovered Youan hospital from January 21th till March 20th 2020 were analyzed. Pulmonary fibrosis, represented as consolidation volume on chest CT images, was computed by artificial intelligence (AI)-assisted program. Plasma...
Background: To investigate the risk factors related to aggravation and clinical outcomes in coronavirus disease 2019 (COVID-19) patients.
<bold>Background:</bold> A novel enveloped RNA beta coronavirus, Corona Virus Disease 2019 (COVID-19) caused severe and even fetal pneumonia in China other countries from December 2019. Early detection of patients with COVID-19 is great significance to shorten the disease course reduce mortality. <bold>Methods:</bold> We assembled a retrospective cohort 80 (including 56 mild 24 severe) infection treated at Beijing You'an Hospital. used univariable multivariable logistic regression analyses...
The treatment of COVID-19 in the post-transplant individuals is challenging, primarily due to drug-drug interaction between nirmatrelvir/ritonavir and tacrolimus. Deuremidevir hydrobromide tablets (VV116) an orally small molecule agents target SARS-CoV-2 RdRp inhibits viral replication. It may have a low likelihood interactions has potential provide new option. We described three cases renal transplant patients with concomitant impaired function who developed pneumonia were treated VV116....
Kaempferol is a flavonoid compound that has gained widespread attention due to its antitumor functions. However, the underlying mechanisms are still not clear. The present study investigated effect of kaempferol on hepatocellular carcinoma and mechanisms. induced autophagy in concentration- time-dependent manner HepG2 or Huh7 cells, which was evidenced by significant increase autophagy-related genes. Inhibition pathway, through 3-methyladenine Atg7 siRNA, strongly diminished...
Kaempferol is a flavonoid compound that has gained importance due to its antitumor properties; however, the underlying mechanisms remain be fully understood. The present study aimed investigate molecular of function kaempferol in HepG2 hepatocellular carcinoma cells. was determined reduce cell viability, increase lactate dehydrogenase activity and induce apoptosis concentration‑ time‑dependent manner Additionally, kaempferol‑induced possibly acts via endoplasmic reticulum (ER) stress...
Reformed coke oven gas (RCOG), a hydrogen-rich gas, is promising auxiliary fuel for ironmaking blast furnaces (BFs) lowing the consumption and production cost. It can be practiced via shaft injection. However, effect of RCOG injection on inner state BF performance has not been fully understood. In this research, at investigated using multiphase model, considering respective burden layer structure. The in-furnace phenomena with without are first compared. simulation results show that affected...
Wilson's disease (WD) is an inherited characterized by copper metabolism disorder caused mutations in the adenosine triphosphatase transporting β gene (ATP7B). Currently, WD cell and animal model targeting most common R778L mutation Asia lacking. In addition, mechanisms which hepatocytes resist toxicity remain to be further elucidated. this study, we aimed construct a novel with dissected molecular basics of resistance. A HepG2 line stably expressing ATP7B (R778L cell) was constructed. The...