A5056909108- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Pediatric Urology and Nephrology Studies
- Genetic factors in colorectal cancer
- Ureteral procedures and complications
- Kidney Stones and Urolithiasis Treatments
- Computational Drug Discovery Methods
- BRCA gene mutations in cancer
- COVID-19 Clinical Research Studies
- Therapeutic Uses of Natural Elements
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- Domain Adaptation and Few-Shot Learning
- Prenatal Screening and Diagnostics
- Viral-associated cancers and disorders
- Gout, Hyperuricemia, Uric Acid
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Multimodal Machine Learning Applications
- vaccines and immunoinformatics approaches
Capital Medical University
2010-2025
Beijing Hospital of Traditional Chinese Medicine
2024-2025
Beijing Friendship Hospital
2016-2024
Massachusetts Institute of Technology
2019-2024
Beijing YouAn Hospital
2018-2024
First Affiliated Hospital of Xiamen University
2022-2023
Tongji University
2022
Shanghai Tenth People's Hospital
2022
Jinan University
2021
Kingmed Diagnostics
2015
In this paper, we explore meta-learning for few-shot text classification. Meta-learning has shown strong performance in computer vision, where low-level patterns are transferable across learning tasks. However, directly applying approach to is challenging--lexical features highly informative one task may be insignificant another. Thus, rather than solely from words, our model also leverages their distributional signatures, which encode pertinent word occurrence patterns. Our trained within a...
The treatment of COVID-19 in the post-transplant individuals is challenging, primarily due to drug-drug interaction between nirmatrelvir/ritonavir and tacrolimus. Deuremidevir hydrobromide tablets (VV116) an orally small molecule agents target SARS-CoV-2 RdRp inhibits viral replication. It may have a low likelihood interactions has potential provide new option. We described three cases renal transplant patients with concomitant impaired function who developed pneumonia were treated VV116....
Robertsonian translocations (ROBs) have an estimated incidence rate of 1/1000 births, making this type rearrangement the most common structural chromosomal abnormalities seen in general population. In study, we reports 872 cases ROBs from 205,001 specimens karyotyped postnatally a single accredited laboratory China, including 583 balanced ROBs, 264 unbalanced 9 mosaic and 18 complex ROBs. Ninety-three percent observed were adults with infertility, miscarriage, or offspring(s) known...
Understanding how proteins structurally interact is crucial to modern biology, with applications in drug discovery and protein design. Recent machine learning methods have formulated protein-small molecule docking as a generative problem significant performance boosts over both traditional deep baselines. In this work, we propose similar approach for rigid protein-protein docking: DiffDock-PP diffusion model that learns translate rotate unbound structures into their bound conformations. We...
Quantitative structure-activity relationship (QSAR) models are powerful in silico tools for predicting the mutagenicity of unstable compounds, impurities and metabolites that difficult to examine using Ames test. Ideally, Ames/QSAR regulatory use should demonstrate high sensitivity, low false-negative rate wide coverage chemical space. To promote superior model development, Division Genetics Mutagenesis, National Institute Health Sciences, Japan (DGM/NIHS), conducted Second International...
Purpose: To evaluate the efficacy of combining a tip-bendable suction ureteral access sheath (S-UAS) with gravity-assisted positioning to improve stone-free rates (SFRs) in retrograde intrarenal surgery (RIRS) for upper urinary tract stones (UUTS). Methods: A multicenter retrospective cohort study was conducted across three urological centers from July 2023 August 2024. total 369 patients UUTS treated RIRS using S-UAS were included. Patients categorized into two groups based on surgical...
The COVID-19 has been a severe pandemic all around the world. Nowadays patient with co-infection of HIV and SARS-CoV-2 was rarely reported. Here we reported special case co-infection, which showed prolonged viral shedding duration.The infected 8 years ago through sexual transmission had normal CD4+T cell count. She found positive using real-time Polymerase Chain Reaction (RT-PCR) during epidemic. Most importantly, duration about 28 days.The may be in people living HIV. 14 days isolation...
There are emerging studies suggesting that non-alcoholic fatty liver disease (NAFLD) is a heterogeneous with multiple etiologies and molecular phenotypes. Fibrosis the key process in NAFLD progression. In this study, we aimed to explore phenotypes of particular focus on fibrosis phenotype also changes macrophage subsets subset NAFLD.To assess transcriptomic alterations factors progression, included 14 different datasets tissues. addition, two single-cell RNA sequencing (scRNA-seq) were...
This study describes the cytogenetic characteristics of 7,133 trisomy 21 (Tri21) identified from 247,818 consecutive postnatal cases karyotyped in a single reference laboratory China for period 4 years. The average detection rate Tri21 is 2.88% ranging 3.39% 2011 to 2.52% 2014. decreased rates over years might reflect possible impact noninvasive prenatal testing applied rapidly and elective termination affected pregnancies. 95.32% karyotypes are standard Tri21, 4.53% Robertsonian less than...
Objective: This study reports the initial experience of extraperitoneal laparoscopic radical cystectomy (ELRC) and compared with transperitoneal (TLRC) in treatment selected elderly bladder cancer patients. Patients Methods: A total forty male patients who underwent ELRC (n=19) or TLRC (n=21) ureterocutaneostomy were investigated. Demographic parameters, perioperative variables, oncological outcomes follow-up data retrospectively analyzed. Results: significantly shorter time to exsufflation...
ABSTRACT Introduction There is still a lack of clinical evidence comprehensively evaluating the effectiveness antiviral treatments for COVID‐19 hospitalized patients. Methods A retrospective cohort study was conducted at Beijing You'An Hospital, focusing on patients treated with nirmatrelvir/ritonavir or azvudine. The employed tripartite analysis—viral dynamics, survival curve analysis, and AI‐based radiological analysis pulmonary CT images—aiming to assess severity pneumonia. Results Of 370...
Abstract Obesity is an expanding global public health problem and a leading cause of metabolic disorders. The hepatokine Fetuin B participates in regulating insulin resistance, glucose metabolism liver steatosis. However, the mechanism underlying activation remains unclear. Our previous population-based study demonstrated significant association between serum body fat mass obese population, which indicates its potential mediating obesity-related In present study, we further revealed...
Aims Sacral spinal cord injury (SCI) could induce underactive bladder (UAB). Malfunction of connexin 43 (CX43) regulated by TGF‐β1 might involve in urinary dysfunction. We studied the changes CX43 and TGF‐β1/Smad3 signaling detrusor neurogenic (NB) sacral SCI rats. Methods was produced hemisection (SSCH) or transection (SSCT) between L4 L5 female Wistar BBB scores, residual urine volume weight as well characteristic cystometric parameters at 6th week were used to confirm successful...
Pathogenic variants in cancer susceptibility genes can increase the risk of a spectrum diseases, which clinicians must manage for their patients. We evaluated disease breast (BCSGs) with aim developing comprehensive resource gene-disease associations clinicians.Twelve (ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NF1, PALB2, PTEN, RECQL, STK11, and TP53), all have been conclusively established as BCSGs by Clinical Genome Resource (ClinGen) and/or NCCN guidelines, were investigated. The potential...
In ancient times, the original plants of Citri Exocarpium Rubrum and Grandis had experienced succession change, including tangerine(Citrus reticulata), pomelo(C. grandis), Huazhou grandis 'Tomentosa'), a specific cultivar C. produced in Huazhou, Guangdong. Before Qing Dynasty, tangerine was main plant, while pomelo came to fore Dynasty. 1950 s 1960 s, producing area destroyed, thus it be supplemented with pomelo. From then on, 'Tomentosa' were both listed as Chinese Pharmacopoeia. This paper...
Abstract Background People living with HIV (PLWH) have a higher risk for cancer compared to the general population. The prevalence of renal cell carcinoma (RCC) in PLWH has gradually increased recent years, but relevant data on outcomes after surgery are scarce. We thus evaluated long-term RCC patients and without HIV. Methods This retrospective study included 67 RCC, both positive or negative, who underwent surgical treatment our hospital between January 2012 2021. Demographic details,...
Objectives: To describe the initial experience of retroperitoneal laparoendoscopic single-incision radical nephrectomy (LESI-RN) without special platforms and use conventional laparoscopic instruments assess safety feasibility LESI-RN. Subjects Methods: Twenty patients who underwent LESI-RN were enrolled in this study. A 5-cm arc skin incision was performed at midpoint between costal arch iliac crest on midaxillary line. Trocars 10, 5, 11 mm placed middle, left end, right end incision,...
ABSTRACT Background Pathogenic variants in cancer susceptibility genes can increase the risk of a spectrum diseases. We aim to evaluate disease breast (BCSGs) develop comprehensive resource gene-disease associations for clinicians. Methods Thirteen (ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RECQL, STK11 and TP53), that have been conclusively established as BCSGs by Clinical Genome Resource (ClinGen) NCCN guidelines, were investigated. For these thirteen genes, potential...
The primary objective was to evaluate the safety of anti-PD-1 antibody camrelizumab in people living with HIV (PLWH); secondary tumor response.From May 8, 2018, December 10, 2021, twenty-four patients and advanced cancer as well a CD4+ T-cell count greater than or equal 100 cells/µL were treated daily practice. We describe demographic characteristics, safety, clinical course these 24 PLWH camrelizumab. Safety assessed using current Common Terminology Criteria for Adverse Events (CTCAE)....