A5100657916- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Global Financial Crisis and Policies
- Spinal Fractures and Fixation Techniques
- Pediatric Hepatobiliary Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Spine and Intervertebral Disc Pathology
- Water Quality and Pollution Assessment
- Economic theories and models
- Hepatitis Viruses Studies and Epidemiology
- Cardiovascular Health and Disease Prevention
- Economic Theory and Policy
- Banking stability, regulation, efficiency
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Urban Stormwater Management Solutions
- Monetary Policy and Economic Impact
- Oral microbiology and periodontitis research
- HIV Research and Treatment
- Economic Policies and Impacts
- Monoclonal and Polyclonal Antibodies Research
- Freshwater macroinvertebrate diversity and ecology
- Marine and coastal ecosystems
- Peripheral Artery Disease Management
- Immune Cell Function and Interaction
China Institute of Water Resources and Hydropower Research
2017-2025
Affiliated Hospital of Nantong University
2025
Second Affiliated Hospital of Nantong University
2025
Nantong University
2025
Capital Medical University
2014-2024
South China University of Technology
2021-2024
Dalian Medical University
2018-2024
Chongqing Medical University
2018-2024
Second Affiliated Hospital of Chongqing Medical University
2018-2024
Beijing YouAn Hospital
2013-2023
Arteriosclerosis and atherosclerosis are closely related with cardiovascular disease (CVD) risk. Remnant cholesterol (RC) could predict CVD. However, its effect on joint arteriosclerosis progression remains unclear. This study aims to evaluate the association of RC trajectories in general population.This collected data across five biennial surveys Beijing Health Management Cohort from 2010 2019. Multi-trajectory model was used determine patterns by brachial-ankle pulse wave velocity (baPWV)...
Abstract Collagen, characteristic in biomimetic composition and hierarchical structure, boasts a huge potential repairing cartilage defect due to its extraordinary bioactivities regulated physicochemical properties, such as low immunogenicity, biocompatibility controllable degradation, which promotes the cell adhesion, migration proliferation. Therefore, collagen-based biomaterial has been explored porous scaffolds or functional coatings cell-free scaffold tissue engineering strategy for...
Impaired sensitivity to thyroid hormones is a newly proposed clinical entity associated with hyperuricemia in the subclinical hypothyroid population. However, it unknown whether association exists euthyroid This study aimed explore of impaired (assessed by feedback quantile-based index [TFQI], parametric [PTFQI], thyrotrophic thyroxine resistance [TT4RI] and thyroid-stimulating hormone [TSHI]) quantify mediating effect body mass BMI population.This cross-sectional enrolled Chinese adults...
Abstract Observational epidemiological studies have reported a relationship between remnant cholesterol and stroke. However, the results are inconclusive, causality remains unclear due to confounding or reverse causality. Our objective in this study was investigate causal relevance of risk stroke its subtypes using Mendelian randomization (MR) approach. Genome-wide association (GWASs) including 115,082 European individuals (UK Biobank) were used identify instruments for cholesterol,...
Introduction Altered Immunoglobulin G (IgG) N-glycosylation is associated with aging, inflammation, and diseases status, while its effect on esophageal squamous cell carcinoma (ESCC) remains unknown. As far as we know, this the first study to explore validate association of IgG carcinogenesis progression ESCC, providing innovative biomarkers for predictive identification targeted prevention ESCC. Methods In total, 496 individuals ESCC (n=114), precancerosis (n=187) controls (n=195) from...
Abstract Background To evaluate the association of physical activity (PA) intensity with cognitive performance at baseline and during follow-up. Methods A total 4039 participants aged 45 years or above from China Health Retirement Longitudinal Study were enrolled in visit 1 (2011–2012) followed for function 2 (2013–2014), 3 (2015–2016), 4 (2017–2018). We analyzed PA global cognition, episodic memory, mental intactness using adjusted regression methods evaluated long-term effect multiple...
Abstract Background Despite research efforts, the causative factors that contribute to esophageal squamous cell carcinoma (ESCC) in high-risk areas have not yet been understood. In this study, we, therefore, aimed describe risk associated with ESCC and its precursor lesions. Methods We performed an endoscopic examination of 44,857 individuals aged 40–69 years from five high incidence regions China 2017–2018. Participants were classified as 4 groups normal control, esophagitis, low-grade...
Background We aimed to examine separate and joint associations of remnant cholesterol (RC) accumulation variability with the risk carotid atherosclerosis (CAS) in general population. Methods Results A total 6213 participants who underwent 3 sequential health examinations during 2010 2015 were enrolled followed up until December 31, 2021. Cumulative RC (cumRC) among visits exposure interest our study. Adjusted Cox models performed calculate hazard ratio (HR) 95% CI. C‐statistics, integrated...
Stream ecosystems are the primary receivers of nutrient and organic carbon exported from terrestrial profoundly influenced by land use surrounding landscape. The aquatic impacts anthropogenic often first observed in stream benthic biofilms. We studied biofilms streams flowing through forest (upstream) (downstream) areas southwestern China. results showed that increased both water biofilms, which closely related to differences microbial communities. taxonomic dissimilarity communities was...
Arterial stiffness is a major risk factor and effective predictor of cardiovascular diseases common pathway pathological vascular impairments. Homocysteine (Hcy) uric acid (UA) own the shared metabolic pathways to affect function. Serum has great impact on arterial risk, while mutual effect with Hcy remains unknown yet. This study aimed evaluate serum UA 10-year in general population. From perspective predictive, preventive, personalized medicine (PPPM/3PM), we assumed that combined...
Abstract The current study was designed to explore the clinical significance of serum tissue inhibitor metalloproteinase 4 (TIMP4) levels in rheumatoid arthritis (RA). GSE1919 chip analyzed, differentially expressed genes (DEGs) were identified, and gene ontology as well Kyoto Encyclopedia Genes Genomes analyses identified DEGs conducted. Patients with RA ( n = 96) healthy individuals enrolled this study. Serum from participants collected, RT-qPCR WB have been conducted examine TIMP4 levels;...
Understanding the contribution of macroinvertebrate diversity indices to community stability in urban rivers is critical for developing more effective strategies manage and conserve ecological health maintain sustainable regional economic social development. However, knowledge regarding relationship between environmental factors, multidimensional biodiversity, remains limited. In this study, we investigated relationships among diversity, secondary productivity-to-biomass ratio (SP/B),...
With the promotion of “Belt and Road,” container multimodal transportation between China Europe has faced unprecedented development opportunities. In view increasing concern about carbon emissions uncertainty during transportation, this paper constructs a robust optimization model with emission constraints aims at minimizing both operation cost time. A Nondominated Sorting Genetic Algorithm-II (NSGA-II) is devised to tackle proposed model. After that, exemplifies from Nanjing, Berlin,...
Mesenchymal stem cells (MSCs) have become a promising therapeutic strategy for scleroderma. Exosomes derived from MSCs (MSC-exosomes) possess functional properties similar to those of their source cells. In this study, we aimed explore the potential role MSC-exosomes in treatment were isolated human umbilical cords through ultracentrifugation and characterized. An experimental fibrosis model was established BALB/c mice by subcutaneous injection bleomycin, followed with or MSC infusions once...
Subclinical hypothyroidism is known to increase the risk of cardiovascular diseases and mortality. However, longitudinal association between subclinical incident metabolic syndrome remains unclear.A total 3615 participants from Beijing Health Management Cohort were enrolled 2012 2014 followed through 2019. People placed into euthyroidism groups according serum-free thyroxine TSH concentrations. We used Cox proportional hazards regression models investigate relationship level considering...
Abstract Background Arterial stiffness, glycemic control and blood pressure are risk factors of macrovascular complications in type 2 diabetes. This study aimed to investigate the combined association arterial hypertension status with occurrence diabetic complication. Methods A total 1870 patients diabetes were enrolled from Beijing Health Management Cohort between 2008 2018 as baseline, then followed for complication onset. We proposed a composite score (0–4) by stiffness severity, pool...