A5006314071- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Urticaria and Related Conditions
- Plant biochemistry and biosynthesis
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Asthma and respiratory diseases
- Traditional Chinese Medicine Analysis
- Dermatology and Skin Diseases
- Inflammasome and immune disorders
- Natural product bioactivities and synthesis
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
- Mast cells and histamine
- Diet, Metabolism, and Disease
- Electric Power System Optimization
- Chromatography in Natural Products
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
Harbin Medical University
2018-2025
Second Affiliated Hospital of Harbin Medical University
2018-2025
Zhejiang Chinese Medical University
2024-2025
Ministry of Education of the People's Republic of China
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Institute of Crop Sciences
2025
Chinese Academy of Agricultural Sciences
2025
Shanghai Cell Therapy Research Institute
2023-2024
Southwest Medical University
2023-2024
North China Electric Power University
2023-2024
Extracellular vesicles (EVs) are tiny lipid bilayer-enclosed membrane particles released from a variety of cell types into the surrounding environment. These EVs have massive participated in cell-to-cell communication and interspecies communication. In recent years, plant-derived extracellular (PDEVs) "exosome-like" populations found distinct plants attracted widespread attention. Especially, research on medicinal (MPDEVs) increasing, which considered kind promising natural compound. This...
Traditional seed pretreatment methods cause secondary pollution for the application of various chemicals. This study investigated effect dielectric barrier discharge (DBD) cold plasma on seedling growth. Effects plasma-activated tap water (PATW) and seeds (PAS) were compared germination rates, height, dry weight, chlorophyll content. Results show that with controls these growth parameters all increased by more than 50%. The yields contributions hydrogen peroxide, nitrate, nitrite, ammonium...
Proinflammatory cytokines mediate anxiety and depression in various ways, such as immunity, inflammation, the hypothalamic-pituitary-adrenal axis. This study intended to further explore linkage of common proinflammatory cytokine levels with psoriasis patients.Totally, 150 patients 50 healthy controls (HCs) were included; serum samples collected, then measured by ELISA. Hospital Anxiety Depression Scale (HADS) was assessed.HADS-anxiety (HADS-A) score, HADS-depression (HADS-D) TNF-α, IL-1β,...
The bulbs of the lily plant Fritillaria thunbergii Miq. possess substantial medicinal properties for relieving coughs and clearing lungs. However, excessive pursuit yield during cultivation has led to a decrease in ingredients. Therefore, we aimed investigate effects two single-factor treatments, shading (SK0) potassium application (S0K), their coupling treatment (SK) on bulb biomass substance content, along with role rhizosphere microorganisms. Shading increased content active ingredients...
Mining valuable genes is helpful to breed high-quality Salvia miltiorrhiza exhibiting efficient nitrogen fertilizer utilization efficiency. In the present study, transcriptome sequencing was introduced select candidate transcription factors (TFs) involved in tanshinones' (TAs) and phenolic acids' (PHAs) biosynthesis as well low (LN) stress. totally, 97.71 Gb clean data obtained from fifteen samples 30,975 unigenes were assembled. Among of them, 27,843 successfully annotated. Overall, 8663...
Abstract Background: Generalized pustular psoriasis (GPP), a rare and recurrent autoinflammatory disease, imposes substantial burden on patients society. Awareness of GPP in China remains limited. Methods: This cross-sectional survey, conducted between September 2021 May 2023 across 14 hospitals China, included all ages disease phases. Data collected encompassed demographics, clinical characteristics, economic impact, severity, quality life, treatment-related complications. Risk factors for...
Pre-harvest sprouting (PHS) is a significant challenge affecting global production of wheat (Triticum aestivum L.). Resistance to PHS governed by both genetic and environmental factors, making reliable molecular markers essential for enhancing resistance through marker-assisted selection (MAS). Genes TaMFT-3A TaMKK3-4A have been cloned in are known regulate white-grained varieties. In this study, we assessed the allelic variations these genes their combined effects on using two recombinant...
To clarify the association between single nucleotide polymorphisms (SNPs) in NLRP1 and NLRP3 Psoriasis Vulgaris (PsV) Chinese Han population.We genotyped eight SNPs, four from (rs8079034, rs11651270, rs11657747, rs878329) (rs7512998, rs3806265, rs10754557, rs10733113) each 540 patients with PsV 612 healthy controls population using an improved multiplexed ligation detection reaction (iMLDR) method. The genotype haplotype frequencies were analyzed a case-control study design.We identified two...
(1) Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of with high intra-tumoral heterogeneity. The epithelial-mesenchymal transition (EMT) one the inducers metastasis and migration. However, description EMT process in TNBC using single-cell RNA sequencing (scRNA-seq) remains unclear. (2) Methods: In this study, we analyzed 8938 cellular gene expression profiles from five patients. We first scored each malignant cell based on functional pathways to determine its...
Polygonum perfoliatum L. is an herbal medicine that has been extensively used in traditional Chinese to treat various health conditions ranging from ancient internal surgical and gynecological diseases. Numerous studies suggest P. extract elicits significant anti-tumor, anti-inflammatory, anti-bacterial, anti-viral effects. Nevertheless, the underlying mechanisms of its anti-liver cancer effects remain poorly understood. Our study suggests stem (PPLA) a favorable safety profile exhibits...
Background: Psoriasis, a chronic inflammatory disorder with an unknown cause, significantly impacts the physical and psychological well-being of patients. However, current biomarkers related to psoriasis lack clinical specificity, sensitivity, predictive ability. Methods: In this study, we collected skin lesion tissues from 20 patients normal samples. Additionally, obtained four datasets GEO database, which included human healthy specimens. We utilized SVM-RFE analysis LASSO regression model...
Among the bioactive compounds, lipid-soluble tanshinone is present in Salvia miltiorrhiza , a medicinal plant species. While it known that ethephon has ability to inhibit tanshinones biosynthesis S. hairy root, however underlying regulatory mechanism remains obscure. In this study, using transcriptome dataset of root induced by ethephon, an ethylene-responsive transcriptional factor EIN3-like 1 ( SmEIL1 ) was identified. The protein found be localized nuclei, and confirmed transient...
Psoriasis is a common disease in dermatology, but its etiology and pathogenesis have not been fully elucidated. In recent years, researchers found that HOX transcript antisense RNA (HOTAIR) plays an important role biological processes as long-chain noncoding (lncRNA). The goal of this study was to investigate the association between HOTAIR polymorphisms psoriasis Chinese Han population by screening key candidate single-nucleotide polymorphism (SNPs) sites HOTAIR. A total 269 patients...
Abstract The locus at 17q12 erb‐b2 receptor tyrosine kinase 2 (ERBB2) has been heavily amplificated and overexpressed in gastric cancer (GC), but it remains to be elucidated about the clinical significance of co‐amplification co‐overexpression PGAP3 gene located around ERBB2 GC. profile four GC cell lines tissue microarrays containing 418 primary tissues was assessed investigate co‐amplified genes, evaluate impact genes on malignancy Co‐amplification accompanied with observed a haploid...
The aim of this study was to assess the clinical value diagnosing and locating lower gastrointestinal (GI) bleeding using single photon emission computed tomography (SPECT)/computed (CT) fusion imaging with 99mTc labeled red blood cells ((99m)Tc-RBC). Fifty-six patients suspected GI received a preoperative intravenous injection (99m)Tc-RBC each underwent planar, SPECT/CT abdominal region. location path were diagnosed by contrastive analysis planar imaging. Among 56 selected, there...