A5100458069- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Mast cells and histamine
- Urticaria and Related Conditions
- Acne and Rosacea Treatments and Effects
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Immunotherapy and Immune Responses
- T-cell and Retrovirus Studies
- Nonmelanoma Skin Cancer Studies
- Asthma and respiratory diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cell Adhesion Molecules Research
- Hair Growth and Disorders
- Cutaneous Melanoma Detection and Management
- Biosimilars and Bioanalytical Methods
- Photodynamic Therapy Research Studies
- Pharmaceutical studies and practices
- Allergic Rhinitis and Sensitization
- Pharmacological Effects of Natural Compounds
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Reproductive System and Pregnancy
Peking University
2016-2025
Peking University Third Hospital
2016-2025
Shandong University
2025
National Natural Science Foundation of China
2023
Peking University People's Hospital
2022
Second Xiangya Hospital of Central South University
2022
Central South University
2022
Peking Union Medical College Hospital
2022
Academy of Medical Sciences
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Preimplantation genetic diagnosis and screening are widely accepted for chromosomal abnormality identification to avoid transferring embryos with defects. Massively parallel sequencing (MPS) is a rapidly developing approach genome analysis increasing application in clinical practice. The purpose of this study was use MPS aneuploidies unbalanced rearrangements after blastocyst biopsy. Trophectoderm (TE) samples 38 blastocysts from 16 vitro fertilization cycles were subjected analysis....
Next generation sequencing (NGS) is now being used for detecting chromosomal abnormalities in blastocyst trophectoderm (TE) cells from vitro fertilized embryos. However, few data are available regarding the clinical outcome, which provides vital reference further application of methodology. Here, we present a evaluation NGS-based preimplantation genetic diagnosis/screening (PGD/PGS) compared with single nucleotide polymorphism (SNP) array-based PGD/PGS as control. A total 395 couples...
Abstract Background: Atopic dermatitis (AD) affects approximately 10% of adults worldwide. CM310 is a humanized monoclonal antibody targeting interleukin-4 receptor alpha that blocks and interleukin-13 signaling. This trial aimed to evaluate the efficacy safety in Chinese with moderate-to-severe AD. Methods: multicenter, randomized, double-blind, placebo-controlled, phase 2b was conducted 21 medical institutions China from February November 2021. Totally 120 eligible patients were enrolled...
Avian pathogenic Escherichia coli (APEC), collectively known as causative agent of extraintestinal infections, is an important cause morbidity and mortality in poultry. Currently, quorum sensing (QS), biofilm formation virulence factors are considered novel prospective targets for antimicrobial therapy to control APEC invasion. In addition, inflammatory responses also served the major pathological features This study was aimed explore effect baicalin on APEC-induced responses. After...
Chronic spontaneous urticaria (CSU) is characterized by the development of wheals, itching, and/or angioedema, for ≥6 weeks. In China, non-sedating H1-antihistamines (H1AH) are recommended first-line treatment, with escalation up to 4× standard dose in symptomatic patients achieve control. Treatment options Chinese who remain on H1AH treatment limited. This 20-week randomized, double blind, placebo-controlled, parallel-group study investigated efficacy and safety omalizumab as an add-on...
Abstract Background Xeligekimab (GR1501) is a fully human monoclonal antibody that selectively neutralizes interleukin (IL)-17A and has shown potential efficacy in treating moderate-to-severe psoriasis preliminary trials. Objectives To evaluate the safety of xeligekimab Chinese patients with psoriasis. Methods A total 420 were randomized to 200 mg every 2 weeks (n = 281) or placebo 139) for first 12 weeks, followed by an extension treatment schedule 4 further 40 weeks. Efficacy was assessed...
Abstract Background: Topical finasteride is a novel treatment for men with an androgenetic alopecia (AGA). This study aimed to evaluate the efficacy and safety of topical spray solution in Chinese AGA. Methods: randomized, double-blind, placebo-controlled, phase III trial enrolled 270 individuals AGA from 16 sites across China between December 2021 March 2023. The participants were randomized at ratio 2:1 receive either or placebo once daily 24 weeks. primary endpoint was change baseline...
Abstract Background: Generalized pustular psoriasis (GPP), a rare and recurrent autoinflammatory disease, imposes substantial burden on patients society. Awareness of GPP in China remains limited. Methods: This cross-sectional survey, conducted between September 2021 May 2023 across 14 hospitals China, included all ages disease phases. Data collected encompassed demographics, clinical characteristics, economic impact, severity, quality life, treatment-related complications. Risk factors for...
Abstract Background Lupus erythematosus (LE) is a spectrum of autoimmune diseases. Due to the complexity cutaneous LE (CLE), clinical skin image‐based artificial intelligence still experiencing difficulties in distinguishing subtypes LE. Objectives We aim develop multimodal deep learning system (MMDLS) for human‐AI collaboration diagnosis subtypes. Methods This multi‐centre study based on 25 institutions across China assist subtypes, other eight similar diseases and healthy subjects. In...
Shear Wave Elastography (SWE) is an objective and non-invasive method widely used to quantify the tissue solidity. However, there are concerns about accuracy of skin SWE results due low signal-to-noise ratio (SNR) caused by subcutaneous fat, muscle bone. This article analyzed reproducibility result for therefore evaluated availability SME elasticity involved diseases. Thirty volunteers (mean age: 37 ± 12 years) were selected. taken on abdomen middle tibia in order assess impact bone results....
Acitretin and matrine have been used in the treatment of psoriasis China. This study was designed to investigate role related mechanisms alone combination with acitretin vitro vivo.HaCaT cells were treated at different concentrations 0 (blank control), 0.2, 0.4, 0.8, 1.6 mg/mL for 24, 48, 72 h, respectively. 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium cell viability assay assess growth proliferation HaCaT cells. Cell cycle apoptosis detected by...
Psoriasis is a common chronic recurrent inflammatory disease. Plaque psoriasis accounts for more than 90% of patients. Currently, no therapies are curative. Biologics have greatly improved the clinical efficacy and potentially provide better long-term safety profile, with respect to toxicity major organs, conventional treatments; however, relapse after treatment withdrawal still an important issue. Although maintenance recommended in most guidelines, occurs quite frequently real-world...
FMX101 4%, as a topical foam formulation of minocycline, has been approved by US Food and Drug Administration for the treatment moderate-to-severe acne vulgaris (AV).
Based on the LINAC of BEPCII, a high-polarized, high bightness, energy-tunable, monoenergetic laser compton backscattering (LCS) gamma-ray source is under construction at IHEP. The energy range from 1 MeV to 111 MeV. It powerful and hopeful research platform reveal underlying physics nuclear, basic particles vacuum or check exist physical models, quantum electrodynamic (QED) theories. In platform, 1.064 μm Nd:YAG system 10.6 CO2 are employed. All trigger signals electron control only...