A5100639420- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Malaria Research and Control
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Neuroscience, Education and Cognitive Function
- Pain Management and Placebo Effect
- Pain Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Cancer-related gene regulation
- Heat shock proteins research
- Cancer, Hypoxia, and Metabolism
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Natural product bioactivities and synthesis
- Immunodeficiency and Autoimmune Disorders
- Pharmacy and Medical Practices
Ningbo No. 2 Hospital
2024-2025
Fudan University Shanghai Cancer Center
2023-2024
Shanghai Medical College of Fudan University
2024
Zhejiang University
2023
China Medical University
2011-2023
University of Chinese Academy of Sciences
2020-2022
Hainan Medical University
2022
Institute of Psychology, Chinese Academy of Sciences
2011-2022
Qingdao University
2022
Nanjing Medical University
2018-2021
Tumor-associated macrophages (TAMs) are the most abundant immune cells within tumor stroma and play a crucial role in development. Although clinical investigations indicate that high levels of macrophage (MΦ) infiltration into tumors associated with poor prognosis, exact played by TAMs during development remains unclear. The present study aimed to investigate dynamic changes TAM major histocompatibility complex (MHC) class II expression assess effects these on progression.Significant...
CD4(+)CD25(+) regulatory T (Treg) cells are crucial mediators of autoimmune tolerance. The factors that regulate Treg cells, however, largely unknown. Here, we show deficiency in midkine (MK), a heparin-binding growth factor involved oncogenesis, inflammation, and tissue repair, attenuated experimental encephalomyelitis (EAE) because an expansion the cell population peripheral lymph nodes decreased numbers autoreactive T-helper type 1 (T(H)1) T(H)17 cells. MK ex vivo dose-dependent manner by...
Background: A T‐helper 17 (Th17)/regulatory T (Treg) imbalance has been suggested recently to play a role in the development of periodontitis. All‐ trans retinoic acid (ATRA) reported modulate Th17/Treg imbalances some diseases. However, effect ATRA on periodontitis remains unknown. This study observes modulation experimental Methods: Experimental was induced mice by oral infection with Porphyromonas gingivalis ( P. ). orally administered every other day. Alveolar bone resorption (ABR)...
We aimed to explore the roles of circular RNAs (circRNAs) in breast cancer (BCa).RNA was extracted from exosomes and BCa cells analyzed using RNA sequencing technique or microarray.Compared with controls, 1147 1195 circRNAs were dysregulated metastatic localized patients, respectively. A total 480 found patients compared these enriched eight pathways. Compared MCF-7 their exosomes, there 5842 1137 MDA-MB-231 respectively, 5 confirmed real-time quantitative PCR.We identified a number patients.
Purpose: Yinyanghuo (Herba Epimdii) is a traditional Chinese herb containing prenylated flavonoids as its active constituents. The aim of this study was to examine the significance intestinal hydrolysis by lactase phlorizin hydrolase (LPH), an enzyme at brush border membrane cells. Methods: A four-site perfused rat model used. concentration interest and their metabolites in different segements were analyzed HPLC, apparent permeabilities calculated. inhibitor (gluconolactone) employed...
Abstract Background Xeligekimab (GR1501) is a fully human monoclonal antibody that selectively neutralizes interleukin (IL)-17A and has shown potential efficacy in treating moderate-to-severe psoriasis preliminary trials. Objectives To evaluate the safety of xeligekimab Chinese patients with psoriasis. Methods A total 420 were randomized to 200 mg every 2 weeks (n = 281) or placebo 139) for first 12 weeks, followed by an extension treatment schedule 4 further 40 weeks. Efficacy was assessed...
The response rate to PD-1/PD-L1 immune checkpoint inhibition (ICI) therapy in melanoma remains low due the immunosuppressive tumor microenvironment.
Background Several agents for oncolytic immunotherapy have been approved clinical use, but monotherapy is modest most agents. The combination of several therapeutic strategies through recombinant and nanotechnology to engineer multifunctional viruses a promising strategy. Methods An endothelium-targeting iRGD-liposome encapsulating Newcastle disease virus (NDV), which expresses the dendritic cell (DC) chemokine MIP-3α (iNDV3α-LP), three control liposomes were constructed. MIP-3α, HMGB1, IgG,...
Abstract Background Management of moderate‐to‐severe atopic dermatitis (AD) needs long‐term therapy. Stapokibart is a humanized monoclonal antibody targeting interleukin‐4 receptor α subunit (IL‐4Rα), shared for IL‐4 and IL‐13 which are key pathogenic drivers AD. In pivotal phase 3 trial (NCT05265923), significant higher proportions adult AD patients receiving stapokibart than placebo achieved ≥75% improvement from baseline in Eczema Area Severity Index (EASI‐75; 66.9% vs. 25.8%)...
Placebo analgesia is one of the most robust and best-studied placebo effects. Recent researches suggest that activated μ-opioid receptor signalling in human brain. However, whether other opioid receptors are involved remains unclear. We have previously evoked responses mice (Guo et al. 2010, 2011) these may serve as a model for investigating analgesia. In present study, we tried to explore site action types response. Male Sprague-Dawley rats were trained with 10 mg/kg morphine 4 d establish...
Abstract: Background: Stapokibart has been approved for the treatment of adults with atopic dermatitis (AD) in China.
Abstract: Targeted delivery by the folate ligand is an effective way to enhance anti-breast carcinoma effect, due its high affinity for receptor, which overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified TiO 2 nanocarrier. Then, FA-PEG-TiO nanoparticle (NP) codelivery system loaded with curcumin salvianolic B were prepared emulsion evaporation–solidification at low temperature. The obtained folate-targeted...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death in China. The lack an effective treatment for this disease results a high recurrence rate patients who undergo radical tumor resection, and 5-year survival these remains low. Our previous studies demonstrated that Plasmodium infection provides potent antitumor effect by inducing innate adaptive immunity murine Lewis lung (LLC) model.This study aimed to investigate inhibitory on hepatocellular mice, various...
Injectable shear-thinning hydrogel for enhancing localized immunotherapy of gastric cancer through repolarization tumor-associated macrophages.
a,c 王克威 ( a 青岛大学药学院 山东青岛 266073) b 青岛科技大学化工学院 266042