A5101991706- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Cancer, Lipids, and Metabolism
- Cardiac Arrhythmias and Treatments
- Pregnancy and preeclampsia studies
- Atrial Fibrillation Management and Outcomes
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- Cancer Risks and Factors
- Hormonal Regulation and Hypertension
- Inhalation and Respiratory Drug Delivery
- Endometrial and Cervical Cancer Treatments
- Bacterial biofilms and quorum sensing
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- PI3K/AKT/mTOR signaling in cancer
- Aquatic life and conservation
- Prion Diseases and Protein Misfolding
Nanjing Jiangning Hospital
2020-2025
Nanjing Medical University
2020-2025
Jiangsu Province Hospital
2023
Shanghai Blood Center
2008
Abstract Squamous intraepithelial lesion of cervix (SIL) in human papillomavirus (HPV)-positive patient often undergoes a silent and long-course development, most them with high-grade transit to cervical squamous cell carcinoma (CSCC). The oxysterol 25-hydroxycholesterol (25-HC) is associated HPV inhibition, autophagy cholesterol synthesis, however, its function this long process SIL development remain unclear. In study, we demonstrate that 25-HC generation inhibited through HSIL-to-CSCC...
Pseudomonas aeruginosa (P. aeruginosa) infections lead to a high mortality rate for cystic fibrosis or immunocompromised patients. The alginate of the biofilm was believed be key factor disabling immune therapy and antibiotic treatments. A silver nanocomposite consisting nanoparticles mesoporous organosilica layer created deliver two pharmaceutical compounds (alginate lyase ceftazidime) degrade eradicate P. from lungs. introduction thioether-bridged into nanocomposites greatly benefited...
Abstract Cervical squamous cell carcinoma (CSCC) is a type of female cancer that affects millions families worldwide. Human papillomavirus (HPV) infection the main reason for CSCC formation, and intraepithelial lesions (SILs) induced by high-risk HPV (HR-HPV) are considered precancerous lesions. A previous study reported HPV-infected cells were able to counteract lipid peroxidation survival. Recent research has ferroptosis acts in an iron-dependent manner kill cells, it proposed as new...
Injectable shear-thinning hydrogel for enhancing localized immunotherapy of gastric cancer through repolarization tumor-associated macrophages.
In the background of endometrial hyperplasia triggered by obesity and estrogen, could perilipin 2 (PLIN2) serve as a possible prognostic marker for early atypical (AEH)? A retrospective study examined blood lipid levels in cancer (EC) or AEH patients. An mice model was established administrating with estradiol and/or high-fat (HF) diet. Hematoxylin eosin staining were employed to assess pathological changes endometrium. Immunohistochemical evaluate expression adipose metabolism proteins. The...
Polycystic ovary syndrome (PCOS) is a condition resulting from the interaction between environmental factors and hereditary components, profoundly affecting offspring development. Although etiology of this disease remains unclear, aberrant in utero androgen exposure considered one pivotal pathogenic factors. Herein, we demonstrate intergenerational inheritance PCOS-like phenotypes F2 female through F1 males caused by maternal testosterone F0 mice. We found impaired serum hormone expression...
Despite recent preclinical progress with oncolytic bacteria in cancer therapy, dose-limiting toxicity has been a long-standing challenge for clinical application. Genetic and chemical modifications enhancing the bacterial tumor-targeting ability have unable to establish balance between increasing its specificity effectiveness while decreasing side effects. Herein, we report simple, highly efficient method rapidly self-assembling clinically used lipid on bacterium reducing minimum effective...
Abstract Background Persistent left superior vena cava (PLSVC) is the most prevalent form of thoracic venous abnormality and can serve as a significant arrhythmogenic source in atrial fibrillation (AF). Methods results Among 3950 patients who underwent radiofrequency ablation for AF between September 2014 to April 2020, 17 (mean age 59.4 ± 8.0 years, 64.7% male) with PLSVC were identified. them, nine (52.9%) had prior history pulmonary vein isolation (PVI) alone. Eight out experienced...
Prenatal androgen exposure induces metabolic disorders in female offspring. However, the long-term effect of maternal testosterone excess on glucose metabolism, especially pancreatic beta-cell function, is rarely investigated. Our current study mainly focused effects prenatal metabolism and beta- cell function aged By using mice their offspring as animal models, we found that treatment induced obesity intolerance These influences were accompanied by decreased fasting serum insulin...
This article is aimed at exploring the relationship between phosphatase 2A catalytic subunit Cα (PP2Acα, encoded by PPP2CA) and methyltransferase-like 3 (METTL3) in malignant progression of gastric cancer (GC). Through analyzing bioinformatics database clinical tissue immunohistochemistry results, we found that abnormal PP2Acα METTL3 levels were closely related to GC. To explore internal connection GC, carried out cellular molecular experiments finally proved inhibition can upregulate...
Long non-coding RNA (lncRNA) plays an important role in tumorigenesis. The lncRNA CCND2 AS1 has been shown to be involved the growth of several tumors; however, its cervical cancer not elucidated. This study aimed explore expression, function, and underlying mechanism action cancer. Expression was examined adjacent normal tissues by quantitative real-time polymerase chain reaction (qRT-PCR) bioinformatic analysis data from Gene Profiling Interactive Analysis (GEPIA) database. function...
Abstract Lactate accumulated in Tumor is a key oncometabolite and associated with various oncogenic processes, including proliferation, invasion, angiogenesis, metastasis, immunosuppression therapeutic resistance. Particularly, lactate contributes to the apoptosis ferroptosis resistance cancer cells. Consequently, blockade of provides promising opportunity for therapy. However, due abnormal tumor microenvironment (TME) intracellular glutathione (GSH) mediated resistance, current approaches...
Catheter ablation is an established therapeutic strategy to treat scar-related macroreentry atrial tachycardia (MAT). However, the scar properties and arrhythmogenicity reentry type have not been clearly defined.A total of 122 patients with MAT were enrolled in this study. The scars classified into two categories: spontaneous (Group A: n = 28) iatrogenic B: 94). According relationship between location circuit, was described as pro-flutter MAT, scar-dependent scar-mediated MAT. significantly...
Psoriasis, a common skin disease, endangers human physiological and mental health; however, its pathogenesis remains unclear. Keratinocyte proliferation is typical pathological characteristic of psoriasis. Serine/threonine protein phosphatase 2A (PP2A) one the most important phosphatases for maintaining normal phosphorylation levels in humans. PP2Acα alpha subtype PP2A C subunit (encoded by PPP2CA), which maintains catalytic functions PP2A. Epidermal growth factor receptor (EGFR) activated...