A5101722506- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Tendon Structure and Treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- melanin and skin pigmentation
- Pluripotent Stem Cells Research
- Cognitive and developmental aspects of mathematical skills
- Endoplasmic Reticulum Stress and Disease
- Sperm and Testicular Function
- Reading and Literacy Development
- Skin Protection and Aging
- Extracellular vesicles in disease
- Xenotransplantation and immune response
- Ferroptosis and cancer prognosis
- Environmental Toxicology and Ecotoxicology
- Musculoskeletal synovial abnormalities and treatments
- Aortic Disease and Treatment Approaches
- Inflammation biomarkers and pathways
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Hormonal Regulation and Hypertension
- Bacterial biofilms and quorum sensing
Beijing Normal University
2024
Institute of Zoology
2023-2024
Chinese Academy of Sciences
2014-2024
Nanjing Jiangning Hospital
2018-2024
Nanjing Medical University
2018-2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
University of Florida
2023
University of Chinese Academy of Sciences
2023
Anhui Agricultural University
2023
// Wei-ming Fu 2, * , Ying-fei Lu 3, Bao-guang Hu 4 Wei-cheng Liang 5 Xiao Zhu 6 Hai-di Yang 7 Gang Li 8 Jin-fang Zhang 1, 1 School of Medicine, South China University Technology, Guangzhou 511458, P.R. 2 Institute Advanced Chinese Academy Sciences, 3 Department Orthopaedics and Traumatology, The Hong Kong, Prince Wales Hospital, Shatin, Gastrointestinal Surgery, Affiliated Hospital Binzhou Medical University, Binzhou, Shandong, Biomedical Faculty P. R. Guangdong Province Key Laboratory...
Long noncoding RNAs (lncRNAs), which serve as important and powerful regulators of various biological activities, have gained widespread attention in recent years. Emerging evidence has shown that some lncRNAs play regulatory roles osteoblast differentiation mesenchymal stem cells (MSCs), suggesting a potential therapeutic strategy for bone fracture. As recently identified lncRNA, linc-ROR was reported to mediate the reprogramming ability differentiated into induced pluripotent (iPSCs) human...
Tendon injures are common orthopedic conditions, but tendon development and the pathogenesis of injures, such as tendinopathy, remain largely unknown have limited clinical therapy. Studies on tenogenic differentiation at molecular level may help in developing novel therapeutic strategies. As regulators, long noncoding RNAs (lncRNAs) been found to widespread biological functions, emerging evidence demonstrates that lncRNAs play important regulatory roles cell tissue regeneration. In this...
MicroRNAs (miRNAs) have been reported to serve as silencers repress gene expression at post-transcriptional levels. Multiple miRNAs demonstrated play important roles in osteogenesis. MicroRNA (miR)-378, a conserved miRNA, was mediate bone metabolism and influence development, but the detailed function underlying mechanism remain obscure. In this study, miR-378 transgenic (TG) mouse developed study role of osteogenic differentiation well formation. The abnormal tissues impaired quality were...
Abstract Newly originated de novo genes have been linked to the formation and function of human brain. However, how a specific gene originates from ancestral noncoding DNAs becomes involved in preexisting network for functional outcomes remains elusive. Here, human‐specific gene, SP0535 , is identified that preferentially expressed ventricular zone fetal brain plays an important role cortical development function. In embryonic stem cell‐derived organoids, knockout compromises their growth...
Abstract Squamous intraepithelial lesion of cervix (SIL) in human papillomavirus (HPV)-positive patient often undergoes a silent and long-course development, most them with high-grade transit to cervical squamous cell carcinoma (CSCC). The oxysterol 25-hydroxycholesterol (25-HC) is associated HPV inhibition, autophagy cholesterol synthesis, however, its function this long process SIL development remain unclear. In study, we demonstrate that 25-HC generation inhibited through HSIL-to-CSCC...
The microphthalmia-associated transcription factor (MITF) is a pivotal regulator of melanogenic enzymes for melanogenesis, and its expression modulated by many transcriptional factors at the level or post-transcriptional through microRNAs (miRNAs). Although several miRNAs modulate activities, there no evidence their direct action on MITF expression. Out eight targeting 3′-UTR Mitf predicted bioinformatic programs, our results show miR-218 to be novel candidate Ectopic dramatically reduced...
Abstract Cervical squamous cell carcinoma (CSCC) is a type of female cancer that affects millions families worldwide. Human papillomavirus (HPV) infection the main reason for CSCC formation, and intraepithelial lesions (SILs) induced by high-risk HPV (HR-HPV) are considered precancerous lesions. A previous study reported HPV-infected cells were able to counteract lipid peroxidation survival. Recent research has ferroptosis acts in an iron-dependent manner kill cells, it proposed as new...
As deubiquitinases, several ubiquitin specific protease members have been reported to mediate tumorigenesis. Although 5 (Usp5) was previously demonstrated suppress p53 transcriptional activity and DNA repair, its role in carcinogenesis remains elusive. In this study, we sought define a novel of Usp5 It found that significantly upregulated hepatocellular carcinoma (HCC) cells most clinical specimens. Further functional investigation also showed knockdown suppressed cell proliferation,...
Recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), as a novel cancer therapeutic, is being tested in phase II and III clinical trials; however, TRAIL resistance remains big obstacle preventing its application. Considering that TRAIL-induced apoptosis through death receptors DR4 DR5, their activation may be an alternative pathway to suppress resistance. In this study, negative correlation between DR5 expression was observed, miR-133a predicted the most...
Macrophage-mediated inflammation plays an essential role in the development of atherosclerosis (AS). Long noncoding RNAs (lncRNAs), as crucial regulators, participate this process. We identified that lnc-MRGPRF-6:1 was significantly upregulated plasma exosomes coronary atherosclerotic disease (CAD) patients a preliminary work. In present study, we aim to assess macrophage-mediated inflammatory process AS.The correlation between and factors estimated firstly CAD patients. Subsequently,...
In the past decade, miRNA emerges as a vital player in orchestrating gene regulation and maintaining cellular homeostasis. It is well documented that influences variety of biological events, including embryogenesis, cell fate decision, differentiation. Adipogenesis an organized process differentiation by which pre-adipocytes differentiate towards mature adipocytes. has been shown adipogenesis tightly modulated number transcription factors such PPARγ, KLF4, C/EBPα. However, molecular...
Polycystic ovary syndrome (PCOS) is a condition resulting from the interaction between environmental factors and hereditary components, profoundly affecting offspring development. Although etiology of this disease remains unclear, aberrant in utero androgen exposure considered one pivotal pathogenic factors. Herein, we demonstrate intergenerational inheritance PCOS-like phenotypes F2 female through F1 males caused by maternal testosterone F0 mice. We found impaired serum hormone expression...
Hyperandrogenism is considered 1 of the most important characteristics polycystic ovary syndrome, which affects more than 10% females reproductive age and a common cause infertility. In addition to effects on patients themselves, maternal androgen excess has also been reported impair growth development offspring. our current study, we found that testosterone (T) treatment during different gestational stages increased percentage atretic follicle decreased corpus luteum formation in female...
Prenatal androgen exposure induces metabolic disorders in female offspring. However, the long-term effect of maternal testosterone excess on glucose metabolism, especially pancreatic beta-cell function, is rarely investigated. Our current study mainly focused effects prenatal metabolism and beta- cell function aged By using mice their offspring as animal models, we found that treatment induced obesity intolerance These influences were accompanied by decreased fasting serum insulin...
Pseudomonas aeruginosa (P. aeruginosa) infections present a grave threat to immunocompromised individuals, particularly those with cystic fibrosis due the development of bacterial biofilms. In this study, we engineered self-assembling chitosan-ceftazidime nanoparticles (CSCE) capable effectively penetrating biofilms and eradicating P. aeruginosa. The CSCE were synthesized through ionic cross-linking, combining negatively charged ceftazidime positively chitosan, resulting in uniform measuring...