A5013418040- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Psoriasis: Treatment and Pathogenesis
- MicroRNA in disease regulation
- Gut microbiota and health
- Circular RNAs in diseases
- Moringa oleifera research and applications
- Metabolomics and Mass Spectrometry Studies
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Barrier Structure and Function Studies
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Polysaccharides and Plant Cell Walls
- Polysaccharides Composition and Applications
- Algal biology and biofuel production
- Advanced Drug Delivery Systems
- Viral Infections and Immunology Research
- Child Nutrition and Water Access
- Venomous Animal Envenomation and Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diet and metabolism studies
- Peptidase Inhibition and Analysis
- Extracellular vesicles in disease
China Pharmaceutical University
2012-2025
Gannan Normal University
2024-2025
Guizhou Provincial People's Hospital
2025
Wenzhou Medical University
2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
Sichuan University
2024
Science and Technology Department of Sichuan Province
2024
Oil Crops Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Thyroid cancer is rapidly increasing in incidence worldwide. Although most thyroid can be cured with surgery, radioactive iodine, and/or chemotherapy, cancers still recur and may become chemoresistant. Autophagy a complex self-degradative process that plays dual role development progression. In this study, we found miR-125b was downregulated tissue samples of as well cell lines, the expression Foxp3 upregulated. Further, demonstrated could directly act on by binding to its 3′ UTR inhibit...
Phycocyanin is a typical microalgal active compound with antioxidant and anti-inflammatory efficacy, the pigment moiety phycocyanobilin has been recently proposed as its structural component. Here, to explore basis for phycocyanin's intestinal protective action, we evaluated therapeutic effects mechanism of action phycocyanin in dextran sodium sulphate (DSS)-induced colitis mice Caco-2 RAW 264.7 cells. Phycocyanobilin was obtained by solvothermal alcoholysis characterized spectroscopy mass...
Tight junctions (TJs) are the most apical intercellular of epithelial cells formed by occludin, claudins, junctional adhesion molecules (JAMs), and zonula occludens (ZO). junction proteins can sense presence bacteria regulate transcription target genes that encode effectors regulators immune response. The aim this study was to determine impact TJ in response Porphyromonas gingivalis (P. gingivalis), P. lipopolysaccharide LPS), extracellular adenosine triphosphate (ATP) oral cell culture...
Microsporidia are eukaryotic, unicellular parasites that have been studied for more than 150 years. These organisms extraordinary in their ability to invade a wide range of hosts including vertebrates and invertebrates, such as human commercially important animals. A lack appropriate labeling methods has limited the research cell cycle protein locations intracellular stages. In this report, an easy fluorescent method developed mark proliferative sporogonic phases microsporidia Nosema...
Microalgae are emerging as a good source of natural nutraceuticals. Here, we examined the intestinal protective effects microalgae aqueous extracts (MAEs) from Chlorella pyrenoidosa, Spirulina platensis, and Synechococcus sp. PCC 7002 in human epithelial Caco-2 cells dextran sodium sulphate (DSS)-induced colitis C57BL/6 mice. MAEs displayed barrier-protective activities by increasing expression heat shock protein (Hsp)-27 tight junction proteins occludin claudin-4 attenuating H2O2-induced...
Human patients carrying genetic mutations in RNA binding motif 20 (RBM20) develop a clinically aggressive dilated cardiomyopathy (DCM). Genetic mutation knockin (KI) animal models imply that altered function of the arginine-serine-rich (RS) domain is crucial for severe DCM. To test this hypothesis, we generated an RS deletion mouse model (Rbm20ΔRS). We showed Rbm20ΔRS mice manifested DCM with mis-splicing RBM20 target transcripts. found was mis-localized to sarcoplasm hearts and formed...
Ulcerative colitis (UC) is an autoimmune disease with a steady increase in global prevalence and long-term susceptibility to colorectal cancer (CRC). CRC often treated XELOX regimen (oxaliplatin capecitabine), which limited by the high toxicity, many adverse reactions intolerance of patients, thus leading termination chemotherapy. Traditional Chinese medicine effective improving patients' clinical symptoms. Gegen Qinlian decoction (GQD) frequently utilized management UC has potential treat...
To integrate tissue engineering concepts into strategies to repair spinal cord injury (SCI) has been a hotspot in recent years, and the choice of scaffolding material is crucial engineering. Recently, decellularized nerve scaffold becomes central concern due its peculiar superiority. In this study, was prepared with three different methods comparison made acquire an ideal materials. All sciatic nerves from Sprague-Dawley (SD) rats were randomly divided four groups: A: normal control group,...
As deubiquitinases, several ubiquitin specific protease members have been reported to mediate tumorigenesis. Although 5 (Usp5) was previously demonstrated suppress p53 transcriptional activity and DNA repair, its role in carcinogenesis remains elusive. In this study, we sought define a novel of Usp5 It found that significantly upregulated hepatocellular carcinoma (HCC) cells most clinical specimens. Further functional investigation also showed knockdown suppressed cell proliferation,...
Microalgae are functional iron nutritive fortifiers that can supply more intestinal nanosized iron.
ABSTRACT The heterogeneity of human umbilical cord mesenchymal stem cells (hUC‐MSCs) is culturing‐dependent, resulting in functional non‐uniformness. To achieve the best clinical benefit, a comprehensive understanding origin different culture systems can identify subgroups to direct precise application hUC‐MSCs. Here, we create single‐cell transcriptome atlas hUC‐MSC for identification subgroup Ultroser‐G‐MSCs with high osteogenic and chondrogenic potentials featured by expressions IL1R1...
<title>Abstract</title> N-acetyl-L-leucine is recognized as an effective and safe medication for managing vertigo related symptoms. It has also been shown to have potential therapeutic benefits GM2 gangliosidoses, Niemann-Pick disease type C, traumatic brain injuries. Up now, there no documentation on its biological production. In this study, we demonstrated the first time development of a biosynthetic pathway in <italic>Escherichia coli</italic>. Firstly, verified N-acetyltransferase...
Chronic periodontitis is characterized by perturbation of the epithelial attachment to tooth with subsequent migration lining epithelium and formation a cleft or pocket. This non-keratinized provides initial responses bacterial products signalling through receptors innate immunity activate inflammasome pathways. These comprise an intracellular network regulatory effector molecules leading synthesis activation pro-inflammatory cytokines. Conversely, CD24 characteristically strongly expressed...
Schisandra chinensis extracts (SEs) have traditionally been used as an oriental medicine for the treatment of various human diseases, however, their further application in biocontrol plant disease remains poorly understood. This study was conducted to develop eco-friendly botanical pesticides from S. and assess whether they could play a key role defense. Concentrated active fractions (SE-I, SE-II, SE-III) were obtained via specific extraction separation. Then, lignan-like substances, such...
// Wei Guo 1 , Dongmei Yu Xin Wang Cheng Luo Yucong Chen Wen Lei Yaoyao Ge Wenyao Xue Qiqi Tian Xiangdong Gao and Wenbing Yao State Key Laboratory of Natural Medicines, School Life Science Technology, China Pharmaceutical University, Nanjing, Correspondence to: Gao, email: Yao, Keywords : collagen-induced arthritis, IL-23, Th17, Treg, Th9, Immunology Microbiology Section, Immune response, Immunity Received March 09, 2016 Accepted April 28, Published May 11, Abstract IL-23 is an important...