A5040921218- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Bone Metabolism and Diseases
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Histone Deacetylase Inhibitors Research
- Craniofacial Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- Tendon Structure and Treatment
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Polyamine Metabolism and Applications
- Proteoglycans and glycosaminoglycans research
- Bone Tissue Engineering Materials
- Proteins in Food Systems
- Neonatal Respiratory Health Research
- Pancreatic function and diabetes
- Estrogen and related hormone effects
- Congenital Anomalies and Fetal Surgery
- Mitochondrial Function and Pathology
- Cellular Mechanics and Interactions
- Bone fractures and treatments
Southern Medical University
2021-2024
Shenzhen Bao'an District People's Hospital
2017-2024
Shenzhen Second People's Hospital
2024
Tianjin University of Science and Technology
2024
Union Hospital
2005-2023
Jilin University
2005-2023
Xi'an Jiaotong University
2023
State Key Laboratory on Integrated Optoelectronics
2023
Second Affiliated Hospital of Fujian Medical University
2022
Fujian Medical University
2022
Bone homeostasis is tightly orchestrated and maintained by the balance between osteoblasts osteoclasts. Recent studies have greatly expanded our understanding of molecular mechanisms cellular differentiation. However, functional roles non-coding RNAs particularly lncRNAs in remodeling bone architecture remain elusive. In study, lncRNA H19 was found to be upregulated during osteogenesis hMSCs. Stable expression significantly accelerated vivo vitro osteoblast Meanwhile, using bioinformatic...
Biopolymer-based supramolecular hydrogels cross-linked by host–guest interactions are usually mechanically weak as shown in "inverted vials" instead of freestanding 3D constructs. Herein, we describe a novel macromer (HGM) approach for preparation biopolymer-based hydrogels. Host–guest macromers formed molecular self-assembly between adamantane-functionalized hyaluronic acid (ADxHA) guest polymers and monoacrylated β-cyclodextrins (mono-Ac-βCD) host monomers. Supramolecular readily prepared...
Breast cancer is the leading cause of death in women. Chemotherapy to inhibit proliferation cells considered be most important therapeutic strategy. The development long-circulating PEG and targeting liposomes a major advance drug delivery. However, techniques used liposome preparation mainly involve conventional liposomes, which have short half-life, high concentrations liver spleen reticuloendothelial system, no active targeting.Four kinds paclitaxel were prepared characterized by various...
Abstract The oxygen evolution reaction (OER) is central to energy conversion technologies, but the high cost and scarcity of commercial noble metal catalysts limit their widespread application. Natural products exhibit great potential in preparing high‐performance electrocatalysts due cost‐effectiveness sustainability. Here, a kind 1D polymers [M‐EA (M═Co, Cu, Ni)] for via complexation ellagic acid (EA) with ions are reported. It found that Ni‐EA displays low overpotential (190 mV at 10 mA...
Tendon injures are common orthopedic conditions, but tendon development and the pathogenesis of injures, such as tendinopathy, remain largely unknown have limited clinical therapy. Studies on tenogenic differentiation at molecular level may help in developing novel therapeutic strategies. As regulators, long noncoding RNAs (lncRNAs) been found to widespread biological functions, emerging evidence demonstrates that lncRNAs play important regulatory roles cell tissue regeneration. In this...
MicroRNAs are small noncoding RNAs involved in numerous biological processes. Emerging pieces of evidence suggest that microRNAs play important roles osteogenesis and skeletal homeostasis. Recent studies indicated the significant regulation function mir-21 vitro , but little information is known about its veritable functions vivo . In present study, we aimed to investigate effect intervention on osteogenic differentiation rats bone marrow derived mesenchymal stem cells (rBMSCs) repair...
A focus of orthopedic research is to improve osteointegration and outcomes joint replacement. Material surface topography has been shown alter cell adhesion, proliferation, growth. The use nanotopographical features promote adhesion bone formation hoped clinical outcomes. Use block‐copolymer self‐assembled nanopatterns allows nanopillars form via templated anodization with control over height order, which be cellular importance. This project assesses the outcome a human marrow‐derived...
Distraction osteogenesis (DO) is one of the most dramatic reconstructive techniques for inducing bone regeneration, but it involves an undesirably long period consolidation. Developing innovative approaches to enhance consolidation a burning need. Human fetal mesenchymal stem cells (hFMSCs) have been shown express more primitive developmental genes than those human adult (hAMSCs), which preferable source cell therapy and tissue regeneration. In present study, we investigated immunogenicity...
Distraction osteogenesis (DO) is a unique technique for promoting bone formation in clinical practice. However the underlying mechanism remains elusive. As epigenetic mediators, microRNAs have been reported to play important roles regulating osteogenesis. In this study, after successfully established DO model of rats, microRNA microarray was performed find molecular targets DO. Total 100 were identified as differently expressed, with miR-503 being one most significantly up-regulated miRNAs...
Summary To improve long‐term stability of the liposomes, resveratrol ( RES ) epigallocatechin gallate EGCG + liposomes coated with low methoxyl pectin LMP were prepared, and their physical properties evaluated. The prepared have a particle sizes about 110 – 160 nm. ‐coated composite largest size zeta potential, latter indicating higher system stability. Liposome systems pasteurised placed in an orange juice as to study liposome real food environment. bridge metal ions forming network‐like...
Cartilage loss is a leading cause of disability among adults, and effective therapy remains elusive. Human mesenchymal stem cells (hMSCs), which have demonstrated self‐renewal multipotential differentiation, are promising cell source for cartilage repair. However, the hypertrophic differentiation chondrogenically induced MSCs resulting tissue calcification hinders clinical translation Here, multifunctional nanocarrier based on quantum dots (QDs) developed to enhance chondrogenic suppress...
Aims: Aberrant expression of microRNA-340 (miR-340) has been frequently reported in some cancers excluding ovarian cancer (OC). The role and its molecular mechanism miR-340 OC have not reported. Methods: Real-time PCR was performed to detect the cell lines. MiR-340 mimic negative control were transfected into cells effects on proliferation, cycle, apoptosis metastasis investigated by Brdu-ELISA assay, flow cytometry, qRT-PCR, Transwell ELISA assays. Furthermore, protein level NF-κB1 measured...
The management of tendon tissue injury presents a significant clinical challenge due to the unique properties tendons. Cell-based therapy provides new alternative for regenerating functional tendons, such as in rupture repair, but largely remains at preclinical research stage. A cell source graft preparation is essential successful clinic application. In this study, novel coculture system bone marrow mesenchymal stem cells (BMSCs) and tendon-derived (TDSCs) was developed investigated. BMSCs...
Chemotherapy is still the main first-line treatment for advanced metastatic gastric cancer, but it has limitations of serious side effects and drug resistance. Conventional liposome been substantially used as carriers, they lack targeting character with lower bioavailability in tumor tissues. Based on above problems, a novel estrogen-targeted PEGylated loaded oxaliplatin (ES-SSL-OXA) was prepared to further improve metabolic behavior, safety profile, anti-tumor efficacy oxaliplatin.Four...
A high-throughput screen for inhibitors of the histone acetyltransferase, KAT6A, led to identification an aryl sulfonohydrazide derivative (CTX-0124143) that inhibited KAT6A with IC50 1.0 μM. Elaboration structure-activity relationship and medicinal chemistry optimization discovery WM-8014 (97), a highly potent inhibitor (IC50 = 0.008 μM). competes acetyl-CoA (Ac-CoA), X-ray crystallographic analysis demonstrated binding Ac-CoA site. Through inhibition activity, induces cellular senescence...
Tendons are a mechanosensitive tissue, which enables them to transmit bone forces that derived from muscle. Patients with tendon injuries, such as tendinopathy or rupture, were often observed matrix degeneration, and the healing of injuries remains challenge result limited understanding biology. Our study demonstrates stretch-mediated activation channel, cystic fibrosis transmembrane conductance regulator (CFTR), was up-regulated in tendon-derived stem cells (TDSCs) during tenogenic...
Osteoarthritis (OA) is a common degenerative disease that pathologically characterized by destruction of the joint matrix and reduction articular chondrocytes, resulting in deformity motor dysfunction. However, molecular mechanisms governing this pathology have not been elucidated to date.In study, we determined expression levels lncRNAs, circRNAs, mRNAs extracted from synovial exosomes OA control patients. A network circRNA/lncRNA-miRNA-mRNA interactions was established using MiRanda...
Abstract Although the role of bromodomain‐containing protein 4 (BRD4) in ovarian cancer, pancreatic lymphoma, and many other diseases is well known, its function cutaneous melanoma only partially understood. The results present study show that BRD4 inhibitor JQ1 promotes apoptosis B16 cells by altering mitochondrial dynamics, thereby inducing dysfunction increasing oxidative stress. We found treatment with different concentrations (125 nmol/L or 250 nmol/L) significantly downregulated...