A5014840053- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Cardiovascular Syncope and Autonomic Disorders
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Extracellular vesicles in disease
- Cardiac Ischemia and Reperfusion
- Cardiovascular Effects of Exercise
- Genetic factors in colorectal cancer
- Macrophage Migration Inhibitory Factor
- Mesenchymal stem cell research
- Intermetallics and Advanced Alloy Properties
- Circular RNAs in diseases
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Autophagy in Disease and Therapy
- Chronic Myeloid Leukemia Treatments
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- Heart Rate Variability and Autonomic Control
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2016-2025
Jinzhou Medical University
2012-2025
Affiliated Hospital of Jining Medical University
2025
Sun Yat-sen University
2016-2024
Weifang Medical University
2018-2024
Zhejiang University
2022-2024
Guangxi Normal University
2021-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2021-2024
First Affiliated Hospital of Jinan University
2020-2023
Abstract Background Exosome transplantation is a promising cell-free therapeutic approach for the treatment of ischemic heart disease. The purpose this study was to explore whether exosomes derived from Macrophage migration inhibitory factor (MIF) engineered umbilical cord MSCs (ucMSCs) exhibit superior cardioprotective effects in rat model AMI and reveal mechanisms underlying it. Results Exosomes isolated ucMSCs (MSC-Exo), MIF (MIF-Exo) downregulated (siMIF-Exo) were used investigate...
Background— The high incidence of postprocedural atrial tachycardia reduces the absolute arrhythmia-free success rate extensive ablation strategies to treat nonparoxysmal fibrillation (NPAF). We hypothesized that a strategy targeting low-voltage zones and sites with abnormal electrograms during sinus rhythm (SR-AEs) in left atrium after circumferential pulmonary vein isolation cavotricuspid isthmus patients NPAF is superior. Methods Results— A total 86 consecutive were enrolled study group....
Bcr-AblT315I mutation-induced imatinib resistance remains a major challenge for clinical management of chronic myelogenous leukemia (CML). Herein, we report GZD824 (10a) as novel orally bioavailable inhibitor against broad spectrum Bcr-Abl mutants including T315I. It tightly bound to Bcr-AblWT and with Kd values 0.32 0.71 nM, respectively, strongly inhibited the kinase functions nanomolar IC50 values. The compound potently suppressed proliferation Bcr-Abl-positive K562 Ku812 human CML cells...
Accumulating evidence has shown that mesenchymal stem cell (MSC)-derived exosomes (exo) mediate cardiac repair following myocardial infarction (MI). Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, plays critical role in regulating homeostasis. This study aimed to investigate the cardioprotective effects of exo secreted from bone marrow-MSCs (BM-MSCs) overexpressing MIF rat model MI. plasmid was transducted BM-MSCs. Exo were isolated supernatants BM-MSCs and...
Exosomes (Exo) secreted from mesenchymal stem cells (hMSCs) are protective against myocardial injury. The purpose of the study was to investigate role and mechanisms by which exosomes promote cardiomyocyte survival function following infarction (MI). hMSCs were cultured under hypoxic normoxic conditions. Hypoxia-conditioned hMSC-derived (Hypo-Exo) normoxic-conditioned (Nor-Exo) collected intramyocardially injected into rats with MI. therapeutic effects Hypo-Exo Nor-Exo evaluated after 4...
The composition and biological activity of donor cells is largely determined by the exosomes they secrete. In this study, we isolated from young (Young-Exo) aged (Age-Exo) mesenchymal stem (MSCs) compared their regeneration activity. Young Exo MSCs were more efficient than Aged-Exo at promoting formation endothelial tube, reducing fibrosis, inhibiting apoptosis cardiomyocytes in vitro; improving cardiac structure function vivo hearts rats following myocardial infarction (MI). MicroRNA...
Abstract Background Mesenchymal stromal cells (MSCs) activated with IFN-γ elicit stronger physical effects. Exosomes (Exos) secreted from MSCs show protective effects against myocardial injury. This study aimed to determine whether Exos derived IFN-γ-treated exhibit more potent cardioprotective function and the underlying mechanisms. Methods H9c2 or human umbilical vein endothelial (HUVECs) were treated isolated (Ctrl-Exo) IFN-γ-primed (IFN-γ-Exo) under oxygen glucose deprivation (OGD)...
Catheter ablation for atrial fibrillation (AF) including pulmonary vein isolation and possibly further substrate is the most common electrophysiological procedure. Severe complications are uncommon, but their detailed assessment in a large worldwide cohort lacking. The aim of this study was to determine incidence periprocedural severe provide characterization diagnostic evaluation management these patients undergoing AF ablation. Individual patient data were collected from 23 centers...
Abstract Aims Data about whether empirical superior vena cava (SVC) isolation (SVCI) improves the success rate of paroxysmal atrial fibrillation (PAF) are conflicting. This study sought to first investigate characteristics SVC-triggered and secondly impact electroanatomical mapping–guided SVCI, in addition circumferential pulmonary vein (CPVI), on outcome PAF ablation absence provoked SVC triggers. Methods results A total 130 patients undergoing underwent electrophysiological studies before...
Background Previous studies have shown that frailty increases the risk of new‐onset atrial fibrillation (AF). However, little is known about association between and recurrence AF after radiofrequency ablation. The objective this study was to investigate in patients with who had undergone Methods Results A total 450 >50 years age symptomatic drug‐refractory catheter ablation for first time were retrospectively enrolled. Frailty status evaluated by 11‐factor modified index 5‐factor index....
The beneficial functions of mesenchymal stem cells (MSCs) decline with age, limiting their therapeutic efficacy for myocardial infarction (MI). Macrophage migration inhibitory factor (MIF) promotes cell proliferation and survival. We investigated whether MIF overexpression could rejuvenate aged MSCs increase in MI. Young were isolated from the bone marrow young donors. MSCs, MIF-overexpressing transplanted into peri-infarct region a rat MI model. Aged exhibited lower proliferative capacity,...
Ginsenosides, which have strong biological activities, can be divided into polar or less-polar ginsenosides.This study evaluated the phytochemical diversity of saponins in Panax ginseng (PG) root, American (AG) and notoginseng (NG) root; stem-leaves from (SPG) (SAG) (SNG) root as well obtained following heating acidification [transformed (TPG), transformed (TAG), (TNG), (TSPG), (TSAG), (TSNG)]. The was determined through simultaneous quantification 16 major ginsenosides.The content...
Fascicular ventricular tachycardia (FVT) is a common form of sustained idiopathic left with an Asian preponderance. This study aimed to prospectively investigate long-term clinical outcomes patients undergoing ablation FVT and identify predictors arrhythmia recurrence.Consecutive at single tertiary center were enrolled. Activation mapping was performed the earliest presystolic Purkinje potential during that targeted by radiofrequency ablation. Follow-up clinic visits, ECG, Holter monitoring...
Quercetin, a natural flavonol existing in many food resources, has been reported to be an effective antimicrobial and anti-inflammatory agent for restricting the inflammation periodontitis. In this study, we aimed investigate effects of quercetin on Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide- (LPS-) stimulated human gingival fibroblasts (HGFs). HGFs were pretreated with prior LPS stimulation. Cell viability was evaluated by...
Background Induced pluripotent stem cells (iPSCs) are a novel candidate for use in cardiac cell therapy. However, their intrinsic tumorigenicity requires further investigation prior to clinical setting. In this study we investigated whether undifferentiated iPSCs tumorigenic after intramyocardial transplantation into immunocompetent allogeneic recipients. Methodology/Principal Findings We transplanted 2×104, 2×105, or 2×106 from the established rat iPSC line M13 intramyocardially intact...
Abstract Ischemic cardiomyopathy seriously endangers human health leading to a poor prognosis. Acute myocardial infarction (AMI) is the primary etiology, and pathophysiological process concludes with death of cardiomyocytes caused by acute persistent ischemia hypoxia in coronary arteries. We identified circRNA (circSNRK) which was downregulated rats (MI), however, role it plays MI environment still unclear. This study contained experiments investigate circSNRK regulation cardiac survival...