A5035054330- Helicobacter pylori-related gastroenterology studies
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Metastasis and carcinoma case studies
- Veterinary medicine and infectious diseases
- Mycobacterium research and diagnosis
- Microbial Applications in Construction Materials
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Phytochemicals and Antioxidant Activities
- Molecular Junctions and Nanostructures
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Vitamin C and Antioxidants Research
- Vitamin D Research Studies
- Bacterial biofilms and quorum sensing
- FOXO transcription factor regulation
- Toxin Mechanisms and Immunotoxins
- Insect Pest Control Strategies
- Central Venous Catheters and Hemodialysis
Weifang Medical University
2005-2023
Weatherford College
2023
Kleijnen Systematic Reviews (United Kingdom)
2023
Weifang People's Hospital
2017
Air Force Medical University
2001
Xijing Hospital
2001
Quercetin, a natural flavonol existing in many food resources, has been reported to be an effective antimicrobial and anti-inflammatory agent for restricting the inflammation periodontitis. In this study, we aimed investigate effects of quercetin on Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide- (LPS-) stimulated human gingival fibroblasts (HGFs). HGFs were pretreated with prior LPS stimulation. Cell viability was evaluated by...
Forkhead box M1 (FOXM1) is a characteristic proliferation‑associated transcription factor, which overexpressed in various types of human cancer. The aim the present study was to determine expression FOXM1 large collection colorectal cancer (CRC) samples. Between March 2012 and January 2014, 96 patients with histologically diagnosed CRC were recruited into current study. Using immunohistochemistry, reverse transcription‑quantitative polymerase chain reaction western blotting, mRNA protein...
To investigate the role of Δ133p53 isoform in nuclear factor-κB (NF-κB) inhibitor pyrrolidine dithiocarbamate (PDTC)-mediated growth inhibition MKN45 gastric cancer cells.The rate cells after treatment with different concentrations only PDTC or PTDC combination cisplatin was detected by CCK-8 assay. mRNA expression levels Δ133p53, p53β, and NF-κB p65 subunit protein were reverse transcription-polymerase chain reaction (RT-PCR) immunofluorescence, respectively. Growth significantly inhibited...
p53 is a tumor suppressor gene whose mutation highly associated with tumorigenesis. The present study investigated the role of p53β in inhibition proliferation gastric cancer cell lines expressing wild‑type or mutated p53. Wild‑type expressed MKN45 cells, but deleted KATOIII whereas SGC7901 cells. mRNA expression levels and Δ133p53 were detected MKN45, SGC‑7901 using nested polymerase chain reaction (PCR). p53, B‑cell lymphoma 2‑associated X protein (Bax) cells following treatment cisplatin...
The etiology of gastric cancer is associated with infectious, environmental and dietary factors, as well genetic background. Additionally, emerging evidence has supported the vital role chronic emotional stress on carcinogenesis; however, underlying mechanism remains unclear. present study aimed to investigate effects a detrimental diet malignant epithelial transformation in rats. Therefore, 26 Wistar rats were randomly divided into following four groups: i) Control; ii) (DD); iii) restraint...
The aim of the present work was to investigate risk factors for gastric cancer- (GC-) associated thrombotic diseases in a Han Chinese population. A total 333 patients diagnosed with GC, 68 included case group and remaining 265 control group, were enrolled. relevant data participants, including general information (gender, age, smoking, drinking), comorbidities (diabetes, hypertension, anemia), tumor-related (tumor site, histology, degree differentiation, clinical stage), treatment-related...
To study the polymorphism of flagellin A genotype and its significance in Helicobacter pylori (H. pylori).As template, genome DNA was purified from six clinical isolates H. outpatients, corresponding fragments were amplified by polymerase chain reaction. All these products sequenced. These sequences compared with each other, analyzed software FASTA program.Specific PCR all no length divergence found among them. Compared highest ungapped identity is 99.10%, while lowest 94.65%. Using program,...
AIM:To demonstrate the effect of Hewei-Decoction (Decoction for regulating stomach) on chronic atrophic gastritis (CAG) and eradication Helicobacter pylori. METHODS:Ninety patients with CAG entering investigation were divided into six differentiation syndromes, based their major symptoms signs.Hewei-Decoction was taken by all orally 4 or 8 wk.The efficacy assessed both composite accumulation reduced scores H ² test used to compare between pylori-positive negative cases, disclose...
The present study aimed to investigate the role of tumour protein 53 isoform b (p53β) on human gastric cancer (GC) cell lines treated with recombinant mutated necrosis factor (rmhTNF) and cisplatin. Cell Counting Kit‑8 assay was used assess growth in GC MKN45 SGC7901, following treatment rmhTNF presence or absence Levels p53β bcl‑2 apoptosis regulator (bcl‑2) mRNA were assessed using reverse transcription‑polymerase chain reaction. results demonstrated that significantly inhibited by either...
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To testify the immunogenicity of a conservative B-cell linear epitope Helicobacter pylori (H pylori) flagellin A.Different programs were used to analyze secondary structure, molecular hydropathy, and surface accessibility H A. Linear epitopes estimated based on structural physiochemical information. Analysis residue divergence was proposed screen epitope. The 29-peptide (Pep29mer) synthesized by chemical method, including predicted known K2d compatible T-cell epitope, immunize mice, then...
To discover the relationship between genotype and antigen serotype of flagellin C among Salmonella strains.Fragment in plasmid pLS408 was cloned, sequenced compared with corresponding sequence other strains. strains including two typhi strains, one paratyphoid strain, enteritidis typhimurium strain were isolated from outpatients. Genome DNA purified respectively these clinical isolates, then fragment amplified by polymerase chain reaction,and amplification products analyzed agarose gel...
Objective To explore the value and difference of narrow band imaging-magnifying endoscopy(NBI-ME)and endoscopic biopsy in diagnosis early gastric cancer precancerous lesions. Methods Fifty patients with suspicious lesions or as revealed by white light endoscopy(WLE)were enrolled study from March 2016 to June Affiliated Hospital Weifang Medical University.All were observed through NBI-ME, types crypt-opening recorded give a diagnosis.Biopsy specimens then taken for pathological...
Objective To assess the effectiveness of using Clip closure defect after endoscopic mucosal resection(EMR), submucosal dissection(ESD)and others to reduce rate delayed postoperative bleeding and accelerate wound healing. Methods Papers published before October 2017 in PubMed、EMBase Cochrance library about EMR, ESD were obtained by computer retrieval.Meta-analysis for each outcome included studies that identified inclusion criteria exclusion was conducted software Review Manager...