A5100397938- Genomics, phytochemicals, and oxidative stress
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Bioactive Compounds and Antitumor Agents
- Bee Products Chemical Analysis
- RNA modifications and cancer
- Liver Disease and Transplantation
- TGF-β signaling in diseases
- Birth, Development, and Health
- Reproductive Physiology in Livestock
- Inflammatory mediators and NSAID effects
- Muscle metabolism and nutrition
- Meat and Animal Product Quality
- Sesame and Sesamin Research
- Sphingolipid Metabolism and Signaling
- Seed and Plant Biochemistry
- Cancer, Hypoxia, and Metabolism
- Seaweed-derived Bioactive Compounds
- Food composition and properties
- Lung Cancer Treatments and Mutations
- Edible Oils Quality and Analysis
- Angiogenesis and VEGF in Cancer
- Eicosanoids and Hypertension Pharmacology
Weifang Medical University
2014-2023
Foshan University
2022
Yamagata University
2000
Air pollution is a serious environmental health problem closely related to the occurrence of central nervous system diseases. Exposure particulate matter with an aerodynamic diameter less than or equal 2.5 µm (PM2.5) during pregnancy may affect growth and development infants. The present study was investigate effects maternal exposure PM2.5 on brain in mice offspring. Pregnant were randomly divided into experimental groups low-, medium-, high-dosages PM2.5, mock-treated group which treated...
Quercetin, a natural flavonol existing in many food resources, has been reported to be an effective antimicrobial and anti-inflammatory agent for restricting the inflammation periodontitis. In this study, we aimed investigate effects of quercetin on Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide- (LPS-) stimulated human gingival fibroblasts (HGFs). HGFs were pretreated with prior LPS stimulation. Cell viability was evaluated by...
Background: The phase II enzyme NAD(P)H : quinone oxidoreductase 1 (NQO1) catalyzes detoxification, protecting cells from redox cycling, oxidative stress, mutagenicity, and cytotoxicity induced by quinones its precursors. We have used NQO1−/− C57BL/6 mice to show that NQO1 protects them skin cancer the polycyclic aromatic hydrocarbon benzo[a]pyrene. Herein, we investigate whether also against 7,12-dimethylbenz[a]anthracene (DMBA), where methyl substituents diminish primary formation....
Several previous studies have demonstrated the excellent antioxidant activity of fucoxanthin against oxidative stress which is closely related to pathogenesis liver diseases. The present work was investigate whether could protect human hepatic L02 cells hydrogen peroxide- (H2O2-) induced damage. Its effects on H2O2-induced cell viability, lactate dehydrogenase (LDH) leakage, intracellular reduced glutathione, and reactive oxygen species (ROS) contents, along with mRNA protein relative levels...
Gonadotropin-releasing hormone (GnRH) has been found to be expressed in ovaries of various species and modulate cell differentiation ovarian cells. GnRH agonists (GnRHa) are widely used the stimulation protocols assisted reproduction. In present study, direct effects a GnRHa on incidence apoptosis sterodogenesis porcine human granulosa cells were investigated. Cells obtained from 6-month-old swine vitro fertilization patients, cultured minimum essential medium (MEM) supplemented with 5%...
Chronic periodontitis (CP) is one of the most common chronic inflammatory diseases and cytokines play a pivotal role in regulation immune response. Interleukin-4 (IL-4) interleukin-13 (IL-13) are anti-inflammatory several polymorphisms them have been proved involved periodontal disease. This study aimed to evaluate whether three single nucleotide (SNPs), rs2070874 rs2243248 from IL4 rs1800925 IL13, associated with CP Han Chinese population consisting 440 moderate or severe patients 324...
This study aimed to investigate the protective effects and mechanisms of myricetin on acute liver failure in mice induced by lipopolysaccharide (LPS)/D-galactosamine (D-Gal). Our results showed (25, 50 100 mg/kg) pretreatment significantly improved pathological changes tissues, decreased serum ALT AST (p < 0.001) LPS/D-GalN. Moreover, MDA MPO levels were reduced 0.001), CAT SOD activities increased with (50 pretreatment. Likewise, inflammatory cytokines TNF-α IL-6 mRNA tissues markedly...
Summary Effects of hydrothermal processing on content changes rutin, quercetin and total flavonoids physicochemical properties Tartary buckwheat ( TB ) enriched dough Chinese steamed bread CSB were investigated. Rutin loss bitterness in made from mixed wheat flour hydrothermally processed decreased markedly compared with control. Total increased after fermentation but afterwards significantly P < 0.05). The development time, stability extensibility, storage moduli tan δ dough, along the...
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid, is recognized as critical regulator in physiological and pathophysiological processes of atherosclerosis (AS). However, the underlying mechanism remains unclear. As precursor cells endothelial (ECs), progenitor (EPCs) can prevent AS development through repairing monolayer impaired by proatherogenic factors. The present study investigated effects S1P on biological features mouse bone marrow-derived EPCs mechanism. results showed that...
Neural tube defects (NTDs) are common congenital malformations. Mitogen-activated protein kinases (MAPKs) pathway is involved in many physiological processes. HMGB1 has been showed closely associated with neurulation and NTDs induced by hyperthermia could activate MAPKs pathway. Since caused increased activation of systems, the present study aims to investigate whether contributes through The mRNA levels between embryonic day 8.5 10 (E8.5-10) defective neural were detected real-time...
The preparation of sesame oil by aqueous extraction is a traditional process with long history. In this study, samples were obtained from key processes in the oil, such as baking, stone grinding, and hot water extraction, changes sensory properties, composition, antioxidant properties studied to control product quality. results showed that flavor color mainly formed Maillard reactions, two for these reactions roasting extraction. Adding reduced total amino acid, alkaline essential acid...