A5101412816- Catalytic Processes in Materials Science
- Plasma Applications and Diagnostics
- Gas Sensing Nanomaterials and Sensors
- Advanced Photocatalysis Techniques
- Metabolism, Diabetes, and Cancer
- TGF-β signaling in diseases
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Genetic Syndromes and Imprinting
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Plasma Diagnostics and Applications
- Cancer-related molecular mechanisms research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neuroblastoma Research and Treatments
- Catalysis and Oxidation Reactions
- Peptidase Inhibition and Analysis
- Polyoxometalates: Synthesis and Applications
- Cancer, Lipids, and Metabolism
- Nanomaterials for catalytic reactions
- Water Quality Monitoring and Analysis
- Eosinophilic Disorders and Syndromes
- Service-Oriented Architecture and Web Services
- Wnt/β-catenin signaling in development and cancer
- PI3K/AKT/mTOR signaling in cancer
Second People's Hospital of Yunnan Province
2024
Yunnan University
2024
Kunming University of Science and Technology
2021-2023
Donghua University
2007-2023
Beijing University of Chemical Technology
2023
Jilin Normal University
2023
Baoshan College
2023
Jingchu University of Technology
2021
Kunming University
2021
Kunming Medical University
2017-2020
Bcr-AblT315I mutation-induced imatinib resistance remains a major challenge for clinical management of chronic myelogenous leukemia (CML). Herein, we report GZD824 (10a) as novel orally bioavailable inhibitor against broad spectrum Bcr-Abl mutants including T315I. It tightly bound to Bcr-AblWT and with Kd values 0.32 0.71 nM, respectively, strongly inhibited the kinase functions nanomolar IC50 values. The compound potently suppressed proliferation Bcr-Abl-positive K562 Ku812 human CML cells...
Abstract A novel strategy for the degradation of high gaseous hourly space velocity benzene, toluene, and xylene (BTX) by double dielectric barrier discharge (DDBD) coupled with Mn 3 O 4 / activated carbon fiber (ACF) catalysts was proposed in this work. series /ACF were synthesized using hydrothermal method characterized. The results showed that all prepared could improve BTX DDBD system inhibit production ozone. Among different loading, 5.6%Mn /ACF, highest Mn(+3) content (43.2%) absorbed...
The degree of difficulty volatile organic compounds (VOCs) degradation in non-thermal plasma (NTP) related to their chemical structures, ionization potentials and hydrogen weight fraction was investigated. Benzene, methylbenzene, xylene, n-pentane, n-hexane, cyclohexane, ethyl acetate, propionate, butyrate, propanone, 2-butanone 2-pentanone, total 12 VOCs were chosen as the typical VOC agents from four main types such aromatic hydrocarbons, alkanes, ketones esters with different structures...
Toluene removal by double dielectric barrier charge (DDBD) plasma combined with a ZrMnFe/Sepiolite (SEP) catalyst was investigated and compared the results from Fe/SEP, Mn/SEP MnFe/SEP ones. All catalysts were prepared impregnation method characterized XRD, BET, ICP, SEM, TEM, H2-TPR XPS. The effect of on toluene degradation efficiency, carbon balance, CO2 selectivity residual O3 concentration studied. experimental indicated that ZrMnFe/SEP presented best catalytic performance. This is...
Low H19 and abundant IGF-II expression may have a role in the development of adrenocortical carcinomas. In mouse, promoter area has been found to be methylated when transcription gene is silent unmethylated it active. We used PCR-based methylation analysis bisulfite genomic sequencing study cytosine status region 16 normal adrenals 30 pathological samples. showed higher at three HpaII-cutting CpG sites carcinomas virilizing adenoma than their adjacent adrenal tissues. Bisulfite revealed...
We designed a series of specifically deuterated benzopyran analogues as new COX-2 inhibitors with the aim improving their pharmacokinetic properties. As expected, compounds retained potency and selectivity for COX-2. The molecules possess improved profiles in rats compared to nondeuterated congeners. Most importantly, showed pharmacodynamic efficacy several murine models inflammation pain. derivatives were separated into enantiomers, activity was found reside S-isomers. To streamline...
The removal of toluene by sepiolite supported with Fe2O3 plasma catalysis was studied. Fe2O3/SEP catalysts were prepared impregnation and characterized Brunauer–Emmett–Teller, inductively coupled plasma, x-ray diffractometer, scanning electron microscopy, photoelectron spectroscopy, H2-TPR. Degradation efficiency under loading, energy yield, carbon balance, CO2 selectivity, residual O3 concentration results show that clay as a carrier can reduce the reduction temperature Fe2O3. catalyst has...
Earlier work implicates transcription factors GATA-4 and GATA-6 in murine adrenal function. We have now studied their expression during mouse human development detail. mRNAs protein are readily detectable from embryonic d 14 gestational wk 19 onwards the cortex, respectively. In postnatal adrenal, is down-regulated, whereas mRNA continue to be expressed. To clarify significance of for early adrenocortical development, Gata4-/- ES cells were injected into eight-cell-stage embryos derived...
Abstract The recently cloned cyclin-dependent kinase inhibitor gene p57KIP2 is genomically imprinted and located on human chromosome 11p15.5. This region contains two other genes, insulin-like growth factor II (IGF-II) H19, both of which seem to be implicated in adrenal neoplasms. We analyzed the expression putative tumor suppressor by Northern blotting normal hyperplastic adrenals, adrenocortical tumors, pheochromocytomas. messenger ribonucleic acid (mRNA) correlated positively with H19...
The humidity effects on the benzene decomposition process were investigated by dielectric barrier discharge (DBD) plasma reactor. results showed that water vapor played an important role in oxidation process. It was found there optimum value for removal efficiency, and at around 60% relative (RH), efficiency achieved. At a SIE of 378 J/L, 66% 0% RH, while reached 75.3% RH dropped to 69% 80% RH. Furthermore, addition inhibited formation ozone NO2 remarkably. Both concentrations decreased with...
Pheochromocytomas are rare sympathoadrenal tumors that highly vascular. Their malignancy is extremely difficult to estimate on the basis of histopathological features. Vascular endothelial growth factor (VEGF) one most important angiogenic factors involved in both tumor and metastasis. In our search for new prognostic markers, we investigated expression VEGF normal adrenal gland, 105 primary pheochromocytomas, 6 metastases by using immunohistochemistry Northern blot analysis. We also...
The present study aimed to explore the function of human bone marrow mesenchymal stem cells (hBMMSCs)-derived exosomal long noncoding RNA histocompatibility leukocyte antigen complex P5 (HCP5) in osteogenic differentiation periodontal ligament (hPDLSCs) improve chronic periodontitis (CP).
Human CLA-1 is homologous to the mouse SR-BI gene, which was recently identified as a high density lipoprotein receptor involved in selective cholesterol uptake rodent adrenal cells. We screened 42 normal and pathological samples by Northern blotting found abundant expression of messenger ribonucleic acid (mRNA) adult fetal adrenals, adrenocortical adenomas, hyperplasias. Adrenocortical carcinomas adrenals adjacent Cushing’s adenomas contained less mRNA than adrenals. also highly expressed...
Malignancy of pheochromocytomas is difficult to estimate on the basis histopathological features. Good prognostic markers are not available. In our search for new differentiate malignant from benign ones we tested value inhibin/activin subunit expression. Inhibins heterodimeric glycoproteins consisting an α-subunit and either a βA- or aβ B-subunit. Activins composed β-subunits only. Immunohistochemically βB-subunit was strongly positive in normal adrenal medulla, but cortex negative. A...
Activins and inhibins are glycoprotein hormones produced mainly in gonads but also other organs. They believed to be important para/autocrine regulators of various cell functions. We investigated activin/inhibin receptor binding protein gene expression the regulation secretion human adrenal cells. RT-PCR revealed inhibin/activin alpha-, betaA/B-subunit, follistatin, activin type I/II receptor, inhibin (betaglycan inhibin-binding protein) mRNA fetal adult adrenals cultured adrenocortical...
Acute kidney injury (AKI) is a common and serious medical condition with high morbidity mortality. Recent research has highlighted ferroptosis, novel form of programmed cell death, as potential therapeutic target in mitigating renal tubular AKI. Ferrostatin-1, specific ferroptosis inhibitor, been demonstrated to prevent through inhibition.Utilizing murine AKI model, we investigated the effects Ferrostatin-1 by administering it post-injury. Through high-throughput sequencing pathological...
Activins and inhibins are often antagonistic in the regulation of ovarian function. TGFβ type III receptor, betaglycan, has been identified as a coreceptor to enhance binding activin II receptor thus prevent activins their receptor. In this study we characterized expression pattern betaglycan gene normal ovaries sex cord-stromal tumors cultured human granulosa-luteal cells from women undergoing vitro fertilization. Expression mRNA was detected by RT-PCR or Northern blotting granulosa,...