A5032984193- Plant biochemistry and biosynthesis
- Lipid metabolism and biosynthesis
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Nanoparticles: synthesis and applications
- Plant Gene Expression Analysis
- Cancer therapeutics and mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Anesthesia and Neurotoxicity Research
- CAR-T cell therapy research
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Polysaccharides and Plant Cell Walls
- Drug Transport and Resistance Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Interference and Gene Delivery
- Insect Resistance and Genetics
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
Soochow University
2013-2025
Yancheng Institute of Technology
2024-2025
Capital Medical University
2022-2025
Hefei University of Technology
2025
Guangdong Pharmaceutical University
2025
Nanjing University of Science and Technology
2013-2024
Brookhaven National Laboratory
2008-2024
Stony Brook University
2012-2024
Zhejiang University
2013-2024
First Affiliated Hospital of Dalian Medical University
2024
Abstract Aliphatic alcohols naturally exist in many organisms as important cellular components; however, their roles extracellular polymer biosynthesis are poorly defined. We report here the isolation and characterization of a rice (Oryza sativa) male-sterile mutant, defective pollen wall (dpw), which displays anther development degenerated grains with an irregular exine. Chemical analysis revealed that dpw anthers had dramatic reduction cutin monomers altered composition cuticular wax, well...
Pesticide residues are a global threat to human health, and conventional sensors fail simultaneously detect pesticide on the surface inside agricultural products. In this work, we present new microneedle (MN) patch-based surface-enhanced Raman spectroscopy (SERS) sensor. The needles basement of MNs can Ag nanoparticles sodium hyaluronate/poly(vinyl alcohol) (HA/PVA) hydrogel used in MN sensor efficiently amplify signals residues. addition, HA/PVA effectively quickly collect residues,...
Studies on hypoxia-sensitive pathways have revealed a series of Fe(II)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and asparaginyl hydroxylation. The recognition these unprecedented signaling processes has led to search for other substrates the HIF hydroxylases. Here we show human hydroxylase, inhibiting (FIH), also efficiently hydroxylates specific (Asn)-residues within proteins IkappaB family. After identification ankyrin repeat domain (ARD)-containing in...
Abstract Male Sterile2 (MS2) is predicted to encode a fatty acid reductase required for pollen wall development in Arabidopsis (Arabidopsis thaliana). Transient expression of MS2 tobacco (Nicotiana benthamiana) leaves resulted the accumulation significant levels C16 and C18 alcohols. Expression fused with green fluorescent protein revealed that an amino-terminal transit peptide targets plastids. The plastidial localization biologically important because genetic complementation ms2 homozygous...
Suberin, a polyester polymer in the cell wall of terrestrial plants, controls transport water and nutrients protects plant from pathogenic infections environmental stresses. Structurally, suberin consists aliphatic aromatic domains; p-hydroxycinnamates, such as ferulate, p-coumarate, and/or sinapate, are major phenolic constituents latter. By analyzing "wall-bound" phenolics mutant lines Arabidopsis deficient family acyl-CoA dependent acyltransferase (BAHD) genes, we discovered that...
Abstract Pectin is a major component of the primary cell wall higher plants. Some galacturonyl residues in backbone pectinaceous polysaccharides are often O-acetylated at C-2 or C-3 position, and resulting acetylesters change dynamically during growth development The processes involve both enzymatic acetylation deacetylation. Through genomic sequence analysis, we identified pectin acetylesterase (PAE1) from black cottonwood (Populus trichocarpa). Recombinant Pt PAE1 exhibited preferential...
Acute leukemia is currently the major cause of death in hematological malignancies. Despite rapid development new therapies, minimal residual disease (MRD) continues to occur and leads poor outcomes. The niche bone marrow microenvironment (BMM) thought be responsible for such MRD development, which can lead drug resistance relapse. Consequently further investigation into way interacts with acute cells (ALCs) strategies block underlying process are expected improve prognosis. Recent studies...
Titanium dioxide nanoparticles (TiO2 NPs) have been used in various medical and industrial areas. However, the impacts of these on neuroinflammation brain are poorly understood. In this study, mice were exposed to 2.5, 5, or 10 mg/kg body weight TiO2 NPs for 90 consecutive days, TLRs/TNF-α/NF-κB signaling pathway associated with hippocampal was investigated. Our findings showed titanium accumulation hippocampus, impairment spatial memory following exposure NPs. Furthermore, significantly...
Biologically produced alkanes represent potential renewable alternatives to petroleum-derived chemicals. A cyanobacterial pathway consisting of acyl–Acyl Carrier Protein reductase and an aldehyde-deformylating oxygenase (ADO) converts Proteins into corresponding n-1 via aldehyde intermediates in oxygen-dependent manner (K m for O 2 , 84 ± 9 µM). In vitro, ADO turned over only three times, but addition more exhausted assays resulted additional product formation. While evaluating the peroxide...
Novel tricyclic benzimidazole carboxamide poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful chemopotentiators of temozolomide and topotecan in both A549 LoVo cell lines. In vitro inhibition PARP-1 was confirmed by direct measurement NAD+ depletion ADP-ribose polymer formation caused chemically induced DNA damage.
A series of novel compounds have been designed that are potent inhibitors poly(ADP-ribose) polymerase-1 (PARP-1), and the activity physical properties characterized. The new structural classes, 3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-ones 3,4-dihydropyrrolo[4,3,2-de]isoquinolin-5-(1H)-ones, conformationally locked benzamide cores specifically interact with PARP-1 protein. evaluated in vitro cellular assays measure ability to enhance effect cytotoxic agents against cancer cell lines.
ABSTRACT Zebrafish ( Danio rerio ) has been used historically for evaluating the toxicity of environmental and aqueous toxicants, there is an emerging literature reporting toxic effects manufactured nanoparticles (NPs) in zebrafish embryos. Few researches, however, are focused on neurotoxicity adult after subchronic exposure to TiO 2 NPs. This study was designed evaluate morphological changes, alterations neurochemical contents, expressions memory behavior‐related genes brains caused by...
Abstract Rice ( Oryza sativa L.) is one of the most important crops in world which survives from various abiotic stresses natural environments with specific stress‐involved genes expressed. Plant sHSP s (small heat‐shock proteins) were reported to respond stresses. To improve understanding rice, we characterized heat‐shock‐protein gene Os HSP 18.6 here. could be induced by diverse stresses, such as drought, salt and cold, especially under heat. The was found expressed root, stem, leaf,...
This study aimed to investigate the pharmacological function and underlying regulation mechanisms of Ginsenoside-Rb3 (G-Rb3) in cardioprotection.Cultured H9C2 cells were pre-treated with gradient concentrations G-Rb3, subsequently challenged hypoxia/reoxygenation (H/R) treatment. The generation intracellular reactive oxygen species (ROS) cellular antioxidatant capacity quantified. Cell apoptosis was measured by flow cytometry. Myocardial ischemia reperfusion injury (MIRI) rat models...
Abstract Exposure to titanium dioxide nanoparticles (TiO 2 NPs) has been demonstrated decrease learning and memory of animals. However, whether the impacts these NPs on recognition function are involved in hippocamal neuron damages is poorly understood. In this study, primary cultured hippocampal neurons from one‐day‐old fetal Sprague‐Dawley rats were exposed 5, 15, or 30 µg/mL TiO for 24 h, we investigated cell viability, ultrastructure, mitochondrial membrane potential (MMP), calcium...
Abstract Plant metacaspases mediate programmed cell death in development, biotic and abiotic stresses, damage-induced immune response, resistance to pathogen attack. Most require Ca 2+ for their activation substrate processing. However, the -dependent mechanism remains elusive. Here we report crystal structures of Metacaspase 4 from Arabidopsis thaliana ( At MC4) that modulates -dependent, plant defense. The MC4 structure exhibits an inhibitory conformation which a large linker domain blocks...