A5014258731- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Contact Dermatitis and Allergies
- Psoriasis: Treatment and Pathogenesis
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Drug-Induced Adverse Reactions
- T-cell and B-cell Immunology
- Cutaneous Melanoma Detection and Management
- Eosinophilic Disorders and Syndromes
- Software System Performance and Reliability
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Food Allergy and Anaphylaxis Research
- Dermatological and Skeletal Disorders
- Inflammatory Myopathies and Dermatomyositis
- Vascular Tumors and Angiosarcomas
- Nonmelanoma Skin Cancer Studies
- Body Contouring and Surgery
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Ear and Head Tumors
First Affiliated Hospital of Fujian Medical University
2016-2025
Fujian Medical University
2016-2025
Xinjiang Academy of Agricultural and Reclamation Science
2024
Ministry of Agriculture and Rural Affairs
2024
Qingdao University
2020-2024
Qingdao Municipal Hospital
2020-2024
Beijing Jiaotong University
2021
Central South University
2020
Fudan University
2018-2019
Ackerman Academy of Dermatopathology
2016
The complexity and dynamism of microservice systems pose unique challenges to a variety software engineering tasks such as fault analysis debugging. In spite the prevalence importance microservices in industry, there is limited research on debugging systems. To fill this gap, we conduct an industrial survey learn typical faults systems, current practice debugging, faced by developers practice. We then develop medium-size benchmark system (being largest most complex open source within our...
Health professions preventing and controlling Coronavirus Disease 2019 are prone to skin mucous membrane injury, which may cause acute chronic dermatitis, secondary infection aggravation of underlying diseases. This is a consensus Chinese experts on protective measures advice hand-cleaning- medical-glove-related hand protection, mask- goggles-related face UV-related eye nasal oral mucosa outer ear, hair protection. It necessary strictly follow standards wearing equipment specification...
Abstract Toxic epidermal necrolysis (TEN) is a fatal drug-induced skin reaction triggered by common medications and an emerging public health issue 1–3 . Patients with TEN undergo severe sudden detachment caused keratinocyte cell death. Although molecular mechanisms that drive death have been proposed, the main drivers remain unknown, there no effective therapy for 4–6 Here, to systematically map changes are associated identify potential druggable targets, we utilized deep visual proteomics,...
Despite the prevalence and importance of microservices in industry, there exists limited research on microservices, partly due to lacking a benchmark system that reflects characteristics industrial microservice systems. To fill this gap, we conduct review literature open source systems identify gap between existing Based results analysis, then develop release medium-size architecture.
Background Bullous pemphigoid (BP) is an autoimmune blistering disorder that predominantly affects the elderly. As main treatment for BP, systemic corticosteroids are often limited by their side effects. Safer modalities therefore needed. Dupilumab a biologic agent used to treat BP in recent years. Methods Medical records of patients with moderate-to-severe were retrospectively reviewed. Twenty-four included (follow-up period: 32 weeks), eight whom received dupilumab combination...
Dermal adipocyte lineage cells are highly plastic and can undergo reversible differentiation dedifferentiation in response to various stimuli. Using single-cell RNA sequencing of developing or wounded mouse skin, we classify dermal fibroblasts (dFBs) into distinct non-adipogenic adipogenic cell states. Cell trajectory analyses identify IL-1-NF-κB WNT-β-catenin as top signaling pathways that positively negatively associate with adipogenesis, respectively. Upon wounding, activation progenitors...
Ten patients were recruited to evaluate the efficacy and safety of abrocitinib for treatment lichen sclerosus (LS). All reported rapid control pruritus at week 2 achieved Investigator’s Global Assessment 0 or 1 12. This study suggests that could be an effective safe option LS, based on significant improvements seen in investigator evaluations, patient-reported outcomes skin imaging findings.
Abstract Background Management of moderate‐to‐severe atopic dermatitis (AD) needs long‐term therapy. Stapokibart is a humanized monoclonal antibody targeting interleukin‐4 receptor α subunit (IL‐4Rα), shared for IL‐4 and IL‐13 which are key pathogenic drivers AD. In pivotal phase 3 trial (NCT05265923), significant higher proportions adult AD patients receiving stapokibart than placebo achieved ≥75% improvement from baseline in Eczema Area Severity Index (EASI‐75; 66.9% vs. 25.8%)...
Umbilical cord-derived mesenchymal stem cells (UC-MSC) are promising candidates for wound healing. However, the low amplification efficiency of MSC in vitro and their survival rates after transplantation have limited medical application. In this study, we fabricated a micronized amniotic membrane (mAM) as microcarrier to amplify used mAM (mAM-MSC) complexes repair burn wounds. Results showed that could live proliferate on 3D culture system, exhibiting higher cell activity than 2D culture....
Atopic dermatitis (AD) is a chronic inflammatory skin disease. 611, humanized monoclonal antibody, selectively targets the interleukin (IL)-4 receptor alpha, thereby inhibiting signaling of both and IL-13. This phase 2 study aimed to evaluate efficacy safety 611 in Chinese adults with moderate-to-severe AD. randomized, double-blind, placebo-controlled was conducted between October 2022 September 2023. Eligible patients AD were randomly assigned 1:1:1 ratio receive at dose either 300 mg...
Generalized pustular psoriasis (GPP) constitutes a rare, severe inflammatory disorder that differs from vulgaris (PV). The IL-36 pathway has been identified as key element in GPP pathogenesis. To explore protein expression between PV and GPP, providing insights into potential mechanisms. We performed proteomic analysis of tissue specimens patients with to identify differentially expressed proteins. Comparative the data was proteins significant differences were further using...
Abstract: Background: Stapokibart has been approved for the treatment of adults with atopic dermatitis (AD) in China.
Microservice systems are complicated due to their runtime environments and service communications. Debugging a failure involves the deployment manipulation of microservice on containerized environment faces unique challenges high complexity dynamism microservices. To address these challenges, we propose debugging approach for based delta algorithm, which is minimalize failure-inducing deltas circumstances (e.g., deployment, environmental configurations). Our includes novel techniques...