A5079702840- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Impact of Technology on Adolescents
- Mental Health Research Topics
- Cerebrovascular and Carotid Artery Diseases
- Esophageal Cancer Research and Treatment
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Traumatic Brain Injury Research
- Gastric Cancer Management and Outcomes
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Posttraumatic Stress Disorder Research
- Cardiovascular Health and Disease Prevention
- Radiomics and Machine Learning in Medical Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Single-cell and spatial transcriptomics
- Circular RNAs in diseases
- Acute Ischemic Stroke Management
- Metabolomics and Mass Spectrometry Studies
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Advanced Image Processing Techniques
- Digital Mental Health Interventions
Qingdao University
2024-2025
Shandong First Medical University
2016-2025
Qingdao Municipal Hospital
2024-2025
Shandong Tumor Hospital
2016-2025
Renji Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
Shanghai Maritime University
2024
Shandong Agricultural University
2024
Vector (United States)
2023
Chongqing Academy of Animal Science
2023
Recent studies suggest that Internet gaming addiction (IGA) is an impulse disorder, or at least related to control disorders. In the present study, we hypothesized different facets of trait impulsivity may be specifically linked brain regions with impaired inhibition function in IGA adolescents. Seventeen adolescents and seventeen healthy controls were scanned during performance a response-inhibition Go/No-Go task using 3.0 T MRI scanner. The Barratt Impulsiveness Scale (BIS)-11 was used...
Quantitative susceptibility mapping (QSM) is a novel MRI technique for the measurement of tissue magnetic in three dimensions. Although numerous algorithms have been developed to solve this ill-posed inverse problem, estimation maps with wide range values still problematic. In cases such as large veins, contrast agent uptake and intracranial hemorrhages, extreme focal areas cause severe streaking artifacts. To enable reduction these artifacts, whilst preserving subtle contrast, two-level QSM...
Purpose Excessive use of the Internet has been linked to a variety negative psychosocial consequences. This study used resting-state functional magnetic resonance imaging (fMRI) investigate whether connectivity is altered in adolescents with gaming addiction (IGA). Methods Seventeen IGA and 24 normal control underwent 7.3 minute fMRI scan. Posterior cingulate cortex (PCC) was determined all subjects by investigating synchronized low-frequency signal fluctuations using temporal correlation...
High Resolution (HR) medical images provide rich anatomical structure details to facilitate early and accurate diagnosis. In magnetic resonance imaging (MRI), restricted by hardware capacity, scan time, patient cooperation ability, isotropic 3-dimensional (3D) HR image acquisition typically requests long time and, results in small spatial coverage low signal-to-noise ratio (SNR). Recent studies showed that, with deep convolutional neural networks, MR could be recovered from low-resolution...
Chromatin accessibility plays a crucial role in mediating transcriptional dysregulation and heterogeneity Esophageal Squamous Cell Carcinoma (ESCC). Examining the chromatin of ESCC at single-cell level is imperative to understand how it activates oncogenes contributes onset metastasis ESCC. We performed assay for transposase-accessible sequencing (scATAC-seq) on cancerous adjacent noncancerous tissues from four patients who were pathological staged as T1a, T2b, T3b, or T4a, investigate...
The goal of this study was to investigate the relationship between resting-state functional connectivity and severity post-traumatic stress disorder (PTSD) symptoms in 15 people who developed PTSD following recent trauma. Fifteen participants experienced acute traumatic events underwent a 7.3-min resting magnetic resonance imaging scan within 2 days post-event. All patients were diagnosed with 1 6 months after Brain areas which activity correlated that posterior cingulate cortex (PCC)...
Purposes Recent neuroimaging studies have shown that people with Internet gaming disorder (IGD) structural and functional abnormalities in specific brain areas connections. However, little is known about the alterations of interhemispheric resting-state connectivity (rsFC) participants IGD. In present study, we used a newly developed voxel-mirrored homotopic (VMHC) method to investigate rsFC whole Methods We compared between 17 IGD 24 healthy controls, group-matched on age, gender, education...
In China, stomach cancer is the third most common and leading cause of death. Few studies have examined Chinese patients' medical expenses their associated trends. The Cancer Screening Program in Urban China (CanSPUC) a Major Public Health Project funded by central government. Through this project, we extracted from hospital billing data to examine costs first course treatments (which refers 2 months before 10 after date diagnosis) patients with expense 14,692 urban were collected 40...
Brain microstructural alterations possibly occur in the normal-appearing white matter (NAWM) and grey of small vessel disease (SVD) patients, may contribute to cognitive impairment. The aim this study was explore related deep nuclei SVD patients using magnetic resonance (MR) quantitative susceptibility mapping (QSM). 170 including 103 vascular mild impairment (VaMCI) 67 no (NCI), 21 healthy control (HC) subjects were included, all underwent a whole-brain QSM scanning. Using atlas,...
Although recent studies have clearly demonstrated functional and structural abnormalities in adolescents with internet gaming addiction (IGA), less is known about how IGA affects perfusion the human brain. We used pseudocontinuous arterial spin-labeling (ASL) magnetic resonance imaging (fMRI) to measure effects of on resting brain functions by comparing cerebral blood flow normal subjects.Fifteen 18 matched underwent fMRI state. Direct subtraction, voxel-wise general linear modeling was...
Cognitive behavior therapy (CBT) is effective for the treatment of Internet gaming disorder (IGD). However, mechanisms by which CBT improves IGD-related clinical symptoms remain unknown. This study aimed to discover therapeutic mechanism in IGD subjects using resting-state functional magnetic resonance imaging (rsfMRI). Twenty-six and 30 matched healthy controls (HCs) received rsfMRI scan assessments; 20 completed then were scanned again. The amplitude low-frequency (ALFF) values...
The dysregulated microRNAs (miRNAs) are involved in diabetic retinopathy progression. Epithelial mesenchymal transition (EMT) and cell permeability important events retinopathy. However, the function mechanism of miR-195 EMT remain largely unclear. Diabetic models were established using streptozotocin (STZ)-induced mice high glucose (HG)-stimulated ARPE-19 cells. Retina injury was investigated by hematoxylin-eosin (HE) staining. analyzed western blotting, immunofluorescence, wound healing,...
Abnormal reductions in cortical cerebral blood flow (CBF) have been identified subcortical vascular cognitive impairment (SVCI). However, little is known about the pattern of CBF reduction relation with degree impairment. measured 3D Arterial Spin Labeling (ASL) perfusion MRI helps detect functional changes subjects SVCI. We aimed to compare maps ischemic disease (SIVD) and without relationship regions brain according z-score. A total 53 SVCI 23 matched SIVD (controls) underwent a...
Chemotherapy resistance remains a major challenge in cancer treatment. COX-2 (cyclooxygenase 2) is involved drug and poor prognosis of many neoplastic diseases or cancers. However, investigations identifying new modulators pathway searching for chemicals targeting these valid resistant biomarkers are still greatly needed. HCT15, HCT-116, HT-29, COLO205, FHC, IMCE, SW480 cell lines were used to detect the expression YAP COX-2. Site-directed mutagenesis, luciferase reporter analysis ChIP assay...
The aim of the current study was to investigate utility diffusional kurtosis imaging (DKI) in detection gray matter (GM) alterations people suffering from Internet Gaming Addiction (IGA). DKI applied 18 subjects with IGA and 21 healthy controls (HC). Whole-brain voxel-based analyses were performed following derived parameters: mean metrics (MK), radial (K⊥), axial (K//). A significance threshold set at P <0.05, AlphaSim corrected. Pearson's correlation correlations between Chen Scale (CIAS)...
The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) their effects on cognition have rarely been investigated. We aimed to examine brain deposition svMCI subjects using quantitative susceptibility mapping (QSM). Moreover, we investigate the correlation between severity as indicated by z-scores. recruited 20 ischemic disease (SIVD) patients who fulfilled criteria for svMCI. control group comprised 19 SIVD without impairment. groups were...
Abstract Esophageal squamous cell carcinoma (ESCC) remains an important health concern in developing countries. Patients with advanced ESCC have a poor prognosis and survival rate, achieving early diagnosis challenge. Metabolic biomarkers are gradually gaining attention as diagnostic biomarkers. Hence, this multicenter study comprehensively evaluated metabolism dysregulation through integrated research strategy to identify key metabolite of ESCC. First, the metabolic profiles were examined...
Purpose To compare four methods of region‐of‐interest (ROI) placement for apparent diffusion coefficient (ADC) measurements in distinguishing low‐grade gliomas (LGGs) from high‐grade (HGGs). Materials and Methods Two independent readers measured ADC parameters using ROI (single‐slice [single‐round, five‐round freehand] whole‐volume) on 43 patients (20 LGGs, 23 HGGs) who had undergone 3.0 Tesla diffusion‐weighted imaging time required each method was recorded. Intraclass correlation...