A5048313363- Hydrogen's biological and therapeutic effects
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Advanced ceramic materials synthesis
- Neuroscience of respiration and sleep
- High Altitude and Hypoxia
- Spinal Cord Injury Research
- Biochemical effects in animals
- Cardiovascular and Diving-Related Complications
- Diabetic Foot Ulcer Assessment and Management
- Electronic and Structural Properties of Oxides
- Advancements in Solid Oxide Fuel Cells
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Magnesium Oxide Properties and Applications
- Fiber-reinforced polymer composites
- Adenosine and Purinergic Signaling
- Mitochondrial Function and Pathology
- Nitric Oxide and Endothelin Effects
- Neuroscience and Neuropharmacology Research
- FOXO transcription factor regulation
- Plant Toxicity and Pharmacological Properties
- Conducting polymers and applications
- Ferroelectric and Piezoelectric Materials
- Respiratory Support and Mechanisms
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2025
Yunnan Normal University
2023
Kunming University of Science and Technology
2019-2022
Ministry of Education
2020
Kunming University
2020
Second Military Medical University
2009-2019
University of Kentucky
2014
Changhai Hospital
2008-2011
Jiangxi University of Traditional Chinese Medicine
2011
Guangdong Pharmaceutical University
2011
This study tested the hypothesis that spinal cord ischemic tolerance induced by hyperbaric oxygen preconditioning (HBO-PC) is mediated inhibition of early apoptosis. Male Sprague-Dawley rats were preconditioned with consecutive 4 cycles 1-h HBO exposures (2.5 atmospheres absolute [ATA], 100% O2) at a 12-h interval. At 24 h after last pretreatment, underwent 9 min ischemia occlusion descending thoracic aorta in combination systemic hypotension (40 mmHg). Spinal produced marked neuronal death...
In this study, we investigated whether nuclear factor erythroid 2-related 2 (Nrf2) activation in astrocytes contributes to the neuroprotection induced by a single hyperbaric oxygen preconditioning (HBO-PC) against spinal cord ischemia/reperfusion (SCIR) injury. vivo: At 24 h after HBO-PC at 2.5 atmospheres absolute for 90 min, male ICR mice underwent SCIR injury aortic cross-clamping surgery and observed 48 h. significantly improved hindlimb motor function, reduced secondary edema,...
Hydrogen gas is neuroprotective in cerebral ischemia animal models. In this study, we tested the effects of hydrogen saline, which safe and easy to use clinically, a rat model middle artery occlusion (MCAO). Sprague-Dawley male rats weighting 250-280 g were divided into sham, MCAO plus saline groups, subjected 90-min followed by 24 h reperfusion. was injected intraperitoneally at 1 ml/100 body weight. Infarct volume brain water content evaluated different time points after Oxidative stress,...
The concept of self-management has become one the most critical concepts in stroke rehabilitation. This study examined impact a 2-week program on self-efficacy, self-esteem, and health behaviors patients. retrospective was conducted from January 2022 to October with 116 patients who had been admitted hospital diagnosis after admission hospital. 4 primary outcomes: behaviors. Each those outcomes assessed at baseline, postintervention, 1 month postintervention. Fifty-one participants were...
Nicotiflorin is a single component extracted from traditional Chinese medicine Flos Carthami. In this study, we investigated its neuroprotection in permanent focal cerebral ischemia model rats, and an vitro of ischemia. At doses 2.5, 5 10 mg/kg, nicotiflorin administered immediately after the onset markedly reduced brain infarct volume neurological deficits. For primarily cultured neurons suffered 2 h hypoxia followed by 24 reoxygenation, significantly attenuated cell death LDH release....
Hyperbaric oxygen (HBO) preconditioning (HBO-PC) has been testified to have protective effects on spinal cord injury (SCI). However, the mechanisms remain enigmatic. The present study aimed explore of HBO-PC primary rat neurons against oxidative and oxygen-glucose deprivation (OGD) relationship with heat shock proteins (HSPs).Primary after 7 days culture were used in this study. HSPs detected following a single exposure HBO at different time points by Western blot. Using lactate...
Four novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa 2), bakkenolide-IIIa 3) and bakkenolide-IVa 4) were isolated from the extract of rhizome Petasites tricholobus. The structures characterized by using NMR (1)H, (13)C, (1)H- (1)H COSY, HMQC, HMBC, NOESY) mass spectrometry. neuroprotective activity compounds 1 4 was assayed with primary cultured neurons exposed to oxygen-glucose deprivation oxidative insults. Antioxidant evaluated cell-free bioassays. IN VITRO assay results showed...
Hydrogen (H2) has been reported to be effective in the treatment of oxidative injury, which plays an important role process decompression sickness (DCS). This study was designed test whether H2-rich saline (saline saturated with molecular hydrogen) protected rats against DCS.Models DCS were induced male Sprague-Dawley weighing 300-310 g. (0.86 mmol x L(-1)) administered intraperitoneally (10 ml kg(-1)) at 24 h, 12 immediately before compression, and right after fast decompression.H2-rich...
Decompression sickness (DCS) is a major concern in diving and space walk. Hyperbaric oxygen (HBO) preconditioning has been proved to enhance tolerance DCS via nitric oxide. Heat-shock protein (HSP) 70 was also found have protective effects against DCS. We hypothesized that the beneficial of HBO on related levels elevated HSP70. HSPs (70, 27 90) expressed tissues spinal cord lung rats detected at different time points following exposure by Western blot. HSP27 HSP90 showed slight but not...
Diabetic retinopathy is the leading cause of blindness in working population developed countries and also a significant elderly. This study aimed at examining protective effect H(2) saline on diabetic streptozotocin-induced rat model.Sprague-Dawley male rats were divided into 3 groups as follows: (1) nondiabetic control group (non-DM control); (2) (DM (3) receiving therapy saline). Rats DM intraperitoneally injected with saturated (5 mL/kg) every day for 4 weeks. Retinal vascular...
Exposure to hyperbaric oxygen (HBO) can lead seizures. Many studies have demonstrated that there exist a very close relationship between the alteration of cerebral blood flow (CBF) and onset Nitric oxide (NO) may play key role in change CBF during exposure, modulation endothelial nitric synthase (eNOS)-derived NO by HBO is responsible for early vasoconstriction, whereas late HBO-induced vasodilation depends upon large amount from both eNOS neuronal (nNOS). To investigate effect on activity...