A5015201898- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Electrowetting and Microfluidic Technologies
- Renal cell carcinoma treatment
- Cancer Cells and Metastasis
- Renal and related cancers
- MicroRNA in disease regulation
- Biosensors and Analytical Detection
- Circular RNAs in diseases
- High Altitude and Hypoxia
- Pregnancy and preeclampsia studies
- Conducting polymers and applications
- Autophagy in Disease and Therapy
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Respiratory Support and Mechanisms
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Aluminum Alloys Composites Properties
Hunan Cancer Hospital
2020-2025
Central South University
2020-2025
Wuhan Textile University
2016-2025
Second Affiliated Hospital of Nanchang University
2022-2025
Nanchang University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2025
Henan Provincial People's Hospital
2019-2025
Henan University
2019-2025
Zhengzhou University
2019-2025
Chinese PLA General Hospital
2016-2025
Finding a needle in haystack: A new technology is demonstrated to enrich circulating tumor cells (CTCs) with high efficiency by integrating an antibody-coated silicon nanopillar (SiNP, see picture; gray) substrate overlaid polydimethylsiloxane (PDMS) microfluidic chaotic mixer (turquoise). It shows significantly improved sensitivity detecting rare CTCs from whole blood, thus providing alternative for monitoring cancer progression. Detailed facts of importance specialist readers are published...
A nanostructured platform that combines electrospun TiO2 nanofibers (TiNFs)-deposited substrate and cell-capture agent realizes significant capture of circulating tumor cells (CTCs). The enhanced local topographic interactions between the horizontally packed TiNFs deposited substrates extracellular matrix scaffolds, in addition to anti-EpCAM/EpCAM biological recognition, contributes significantly efficiency compared flat surfaces. Detailed facts importance specialist readers are published as...
Although anti-PD-1 immunotherapy is widely used to treat melanoma, its efficacy still has be improved. In this work, we present a therapeutic method that combines and starvation therapy achieve better antitumor efficacy. We designed the CMSN-GOx method, in which mesoporous silica nanoparticles (MSN) are loaded with glucose oxidase (GOx) then encapsulate surfaces of cancer cell membranes realize therapy. By functionalizing MSN's biomimetic surfaces, can synthesize escape host immune system...
Apoptosis serves as a protective mechanism by eliminating damaged cells through programmed cell death. After apoptotic pass critical checkpoints, including mitochondrial fragmentation, executioner caspase activation, and DNA damage, it is assumed that death inevitably follows. However, this assumption has not been tested directly. Here we report an unexpected reversal of late-stage apoptosis in primary liver heart cells, macrophages, NIH 3T3 fibroblasts, cervical cancer HeLa brain cells....
Abstract Biomimetic cell‐membrane‐camouflaged nanoparticles with desirable features have been widely used for various biomedical applications. However, the current research focuses on single cell membrane coating and using multiple membranes nanoparticle functionalization is still challenging. In this work, platelet (PLT) leukocyte (WBC) are fused, PLT–WBC hybrid coated onto magnetic beads, then their surface modified specific antibodies. The resulting membrane‐coated immunomagnetic beads...
Abstract Background Cisplatin (CDDP)-based chemotherapy is a standard first-line treatment for metastatic bladder cancer (BCa) patients, and chemoresistance remains major challenge in clinical practice. Circular RNAs (circRNAs) have emerged as essential regulators carcinogenesis progression. However, the role of circRNAs mediating CDDP chemosensitivity has yet to be well elucidated BCa. Methods CircSTX6 ( hsa_circ_0007905 ) was identified by mining public circRNA datasets verified Sanger...
In this paper we describe a novel method of manufacturing shape-controlled calcium alginate gel microparticles in microfluidic device. Both and synthesizing hydrogel could be performed simultaneously the The device comprised two individual flow-focusing channels channel was successfully applied as continuous reactor to synthesize with size shape control. By passive control based on microchannel geometric confinement liquid-phase flow rates, succeeded producing monodisperse sodium diverse...
Abstract Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent tumours. In this study we analyse genomic profiles of 15 adenocarcinomas and one regional lymph node metastasis from 6 patients with MSLC. All demonstrate distinct profiles, suggesting all are primary tumours, which consistent comprehensive histopathological assessment in 5 the patients. Lung same individuals no more similar each...
Nanoparticles are regarded as promising transfection reagents for effective and safe delivery of nucleic acids into a specific type cells or tissues providing an alternative manipulation/therapy strategy to viral gene delivery. However, the current process searching novel materials is limited due conventional low-throughput time-consuming multistep synthetic approaches. Additionally, approaches frequently accompanied with unpredictability continual optimization refinements, impeding flexible...
PURPOSE SHR-A1811 is an antibody-drug conjugate composed of anti–human epidermal growth factor receptor 2 (HER2) antibody trastuzumab, a cleavable linker, and topoisomerase I inhibitor payload. We assessed the safety, tolerability, antitumor activity, pharmacokinetics in heavily pretreated HER2-expressing or mutated advanced solid tumors. METHODS This global, multi-center, first-in-human, phase trial was conducted at 33 centers. Patients who had unresectable, advanced, metastatic tumors were...
To overcome the strength-ductility conflict in particle reinforced aluminum matrix composites (PRAMCs), a novel dual configuration strategy of microstructure was proposed this work. The including both heterogeneous grain structure and hybrid reinforcements obtained by powder metallurgy, which designed as submicron-sized SiC particles (SiCsm)/Al micron-sized (SiCm)/2024Al components. Representative alternating coarse (CG) bands containing SiCm ultra fine (UFG) with dispersed SiCsm were...
An integrated microfluidic device has been developed to perform 1024 in situ click chemistry reactions parallel using the bovine carbonic anhydrous II (bCAII) system as a proof-of-concept study and rapid hit identification approach SPE purification electrospray-ionization mass spectrometry, multiple reaction monitoring (MRM) analysis, all of which improves sensitivity throughput downstream analysis.
It has been observed that microfluidic chips used for synthesizing 18F-labeled compounds demonstrate visible light emission without nearby scintillators or fluorescent materials. The origin of the was investigated and found to be consistent with characteristics from Cerenkov radiation. Since 18F decays through high-energy positrons, energy threshold beta particles, i.e. electrons generate radiation calculated water polydimethylsiloxane (PDMS), most commonly polymer-based material chips. Beta...
MicroRNAs (miRNAs) are involved in the fine control of cell proliferation and differentiation during development nervous system. MiR-124, a neural specific miRNA, is expressed from beginning eye Xenopus, has been shown to repress optic cup, however, its role at earlier developmental stages unclear. Here, we show that this miRNA exerts different vesicle stage, stage which precedes cup formation. We miR-124 both necessary sufficient promote neurogenesis playing an anti-neural role. Loss...
A simple and effective droplet electric separator microfluidic device was developed for cell sorting. The aqueous without precharging operation influenced to move a distance in the channel along field direction by applying dc voltage on electrodes beside channel, which made target flowing collector. Single can be isolated sorting rate of ∼100 Hz with microelectrodes under required pulse. or multiple mammalian (HePG2) encapsulated surfactant free alginate could sorted out respectively. This...
The transcription factor KLF6 has an essential role in the development and metastasis of multiple human cancers. Paradoxically, expression was found to be attenuated primary metastatic clear cell renal carcinoma (ccRCC), such that it is unclear how affects malignant progression this setting. In study, we demonstrate attenuation cells sufficient promote E2F1-mediated epithelial-mesenchymal transition prowess. a mouse xenograft model ccRCC, silencing increased tumor proliferation character,...
Preeclampsia (PE) is a pregnancy-specific syndrome that substantially leads to maternal and fetal mortality. Multiple factors contribute the disease, but exact pathogenesis still remains elusive. Here we explored roles of lncRNA MALAT1 miR-206 in PE. qRT-PCR was applied measure mRNA levels placenta PE patients. Scratch wound healing assay transwell invasion were conducted test effects on migration trophoblast cells. In addition, validated MALAT1/miR-206 miR-206/IGF-1 interactions with dual...
Nadel im Heuhaufen: Eine neue Technik ermöglicht es, zirkulierende Tumorzellen (CTCs) mit hoher Effizienz anzureichern, indem ein Substrat aus Antikörper-beschichteten Silicium-Nanosäulen (SiNP, siehe Bild; grau) einer chaotisch durchmischenden Mikrofluidikeinheit (türkis) Polydimethylsiloxan (PDMS) bedeckt wird. Das Verfahren detektiert empfindlich seltene CTCs Vollblut und bietet damit eine Alternative für die Überwachung der Krebsprogression. Detailed facts of importance to specialist...