A5051040528- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- Ship Hydrodynamics and Maneuverability
- Maritime Transport Emissions and Efficiency
- Lipid metabolism and disorders
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Neuropeptides and Animal Physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- Aerogels and thermal insulation
- Emergency and Acute Care Studies
- Sulfur Compounds in Biology
- Flame retardant materials and properties
- Chronic Obstructive Pulmonary Disease (COPD) Research
Nanjing Medical University
2011-2024
Target (United States)
2024
Dalian Polytechnic University
2024
Chongqing Jiulongpo People's Hospital
2023
Marine Design & Research Institute of China
2016-2023
Shanghai Ship and Shipping Research Institute
2023
Yangtze University
2021-2022
First Affiliated Hospital of Jinan University
2021
Jingzhou Central Hospital
2021
Increased glucose production and reduced hepatic glycogen storage contribute to metabolic abnormalities in diabetes. Irisin, a newly identified myokine, induces the browning of white adipose tissue, but its effects on gluconeogenesis glycogenesis are unknown. In present study, we investigated underlying mechanisms irisin hepatocytes with insulin resistance, therapeutic role type 2 diabetic mice. Insulin resistance was induced by glucosamine (GlcN) or palmitate human hepatocellular carcinoma...
Inflammation is involved in pathogenesis of hypertension. NLRP3 inflammasome activation a powerful mediator inflammatory response via caspase-1 activation. The present study was designed to determine the roles and mechanisms phenotypic modulation proliferation vascular smooth muscle cells (VSMCs) Experiments were conducted spontaneously hypertensive rats (SHR) primary aortic VSMCs. observed media aorta SHR VSMCs from SHR. Knockdown inhibited activation, VSMC transformation SHR-derived...
Fibronectin type III domain-containing 5 (FNDC5) protein induces browning of subcutaneous fat and mediates the beneficial effects exercise on metabolism. However, whether FNDC5 is associated with hepatic steatosis, autophagy, fatty acid oxidation (FAO), lipogenesis remains unknown. Herein, we show roles mechanisms in lipid Fasted FNDC5−/− mice exhibited severe reduced FAO, enhanced liver compared wild-type mice. Energy deprivation–induced AMPK activity were attenuated hepatocytes, which...
Abstract β-aminoisobutyric acid (BAIBA) is a nature thymine catabolite and contributes to exercise-induced protection from metabolic diseases. Here we show the therapeutical effects of BAIBA on hepatic endoplasmic reticulum (ER) stress glucose/lipid disturbance in diabetes. Type 2 diabetes was induced by combined streptozotocin (STZ) high-fat diet (HFD) mice. Oral administration for 4 weeks reduced blood glucose lipids levels, key enzymes gluconeogenesis lipogenesis expressions, attenuated...
Salusin-β accelerates inflammatory responses in vascular endothelial cells, and increases oxidative stress smooth muscle cells. Plasma salusin-β levels were increased diabetic patients. This study was designed to determine whether is involved the pathogenesis of cardiomyopathy (DCM), knockdown attenuates cardiac inflammation rats with DCM. H9c2 or neonatal rat cardiomyocytes incubated 33.3 mM glucose mimic high (HG) diabetes. Streptozotocin high-fat diet used induce type 2 diabetes rats. HG...
We recently found that adipose afferent reflex (AAR) induced by chemical stimulation of white tissue (WAT) increased sympathetic outflow and blood pressure in normal rats. The study was designed to test the hypothesis AAR contributes activation obesity hypertension. Male rats were fed with a control diet (12% kcal as fat) or high-fat (42% for 12 weeks induce Stimulation WAT capsaicin renal nerve activity mean arterial pressure. Both enhanced hypertension (OH) compared nonhypertension (ON) ON...
Migration of vascular smooth muscle cells (VSMCs) is pivotal for remodeling in hypertension. Vascular adventitial fibroblasts (AFs) are important the homeostasis structure. This study designed to investigate roles AF exosomes (AFE) VSMC migration and underling mechanism. Primary VSMCs AFs were obtained from aorta spontaneously hypertensive rats (SHR) Wistar-Kyoto (WKY) rats. was evaluated with Boyden chamber assay wound healing assay. AFE WKY SHR isolated identified. promoted but had no...
Chronic low-grade inflammation and oxidative stress play important roles in the development of obesity-induced cardiac hypertrophy. Here, we investigated role Fibronectin type III domain containing 5 (FNDC5) Male wild-type FNDC5−/− mice were fed normal chow or high fat diet (HFD) for 20 weeks to induce obesity, primary cardiomyocytes H9c2 cells treated with palmitate (PA) used as vitro model. The therapeutic effects lentiviral vector-mediated FNDC5 overexpression also examined HFD-induced...
Superoxide and vascular smooth muscle cells (VSMCs) migration proliferation play crucial roles in the remodeling. Vascular remodeling contributes to development complications of hypertension. Rho family GTPase 3 (RND3 or RhoE), an atypical small Rho-GTPase, is known be involved cancer metastasis. However, RND3 superoxide production cardiovascular are unknown. Here, we uncovered critical attenuating production, VSMCs proliferation, hypertension its underline mechanisms. were isolated prepared...
Excessive sympathetic activity and norepinephrine (NE) release play crucial roles in the pathogeneses of hypertension.Sympathetic fibers innervate adventitia rather than media arteries.However, NE adventitial fibroblasts (AFs) are unknown.This study investigated regulating AFs-derived extracellular vesicles (EVs) vascular smooth muscle cells (VSMCs) proliferation hypertension.Methods: AFs VSMCs were prepared from aorta Wistar-Kyoto rats (WKY) spontaneously hypertensive (SHR).AFs treated with...
Injection of leptin into white adipose tissue (WAT) increases sympathetic outflow. The present study was designed to determine the effects capsaicin and other chemicals in WAT on outflow blood pressure roles afferents hypothalamic paraventricular nucleus (PVN) afferent reflex (AAR). AAR induced by injection capsaicin, bradykinin, adenosine, adenosine triphosphate (ATP), or inguinal (iWAT) retroperitoneal (rWAT) anesthetized rats. iWAT increased renal nerve activity (RSNA) mean arterial (MAP)...
Salusin-β is a bioactive peptide with peripheral hypotensive, mitogenic and pro-atherosclerotic effects. The present study was designed to determine the roles of salusin-β in paraventricular nucleus (PVN) its relationship arginine vasopressin (AVP) hypertension sympathetic activation.Renovascular induced by two-kidney, one-clip (2K1C) male Sprague-Dawley rats. Acute experiments were carried out 4 weeks after 2K1C or sham-operation under urethane alpha-chloralose anaesthesia. Renal nerve...
Background The enhanced cardiac sympathetic afferent reflex (CSAR) is involved in the activation that contributes to pathogenesis and progression of hypertension. Activation AT1 receptors by angiotension (Ang) II paraventricular nucleus (PVN) augments CSAR outflow present study designed determine whether Ang-(1-7) PVN plays similar roles as Ang interaction between on renovascular Methodology/Principal Findings two-kidney, one-clip (2K1C) method was used induce evaluated renal nerve activity...
Cardiac sympathetic afferent reflex (CSAR) is involved in activation. The present study was designed to investigate the contribution of enhanced CSAR activation early stage diabetes and involvement AT(1) receptors paraventricular nucleus (PVN). Diabetes induced by a single intravenous injection streptozotocin rats. Acute experiments were carried out under anesthesia after 3 wk. evaluated responses renal nerve activity (RSNA) mean arterial pressure (MAP) epicardial application capsaicin or...
Increased reactive oxygen species (ROS) induced by angiotensin II (Ang II) in the paraventricular nucleus (PVN) play a critical role sympathetic overdrive hypertension (OH). Intermedin (IMD), bioactive peptide, has extensive clinically prospects preventing and treating cardiovascular diseases. The study was designed to test hypothesis that IMD PVN can inhibit generation of ROS caused Ang for attenuating nerve activity (SNA) blood pressure (BP) rats with obesity-related Male Sprague-Dawley...
Background Cardiac sympathetic afferent reflex (CSAR) contributes to activation and angiotensin II (Ang II) in paraventricular nucleus (PVN) augments the CSAR vagotomized (VT) baroreceptor denervated (BD) rats with chronic heart failure (CHF). This study was designed determine whether it is true intact (INT) CHF effects of cardiac afferents on activity CHF. Methodology/Principal Findings Sham-operated (Sham) or coronary ligation-induced were respectively subjected BD+VT, VT, denervation...
The adipose afferent reflex (AAR), a sympatho-excitatory reflex, can promote the elevation of sympathetic nerve activity (SNA) and blood pressure (BP). Inflammation in paraventricular nucleus (PVN) involves abnormality some cardiovascular diseases such as hypertension. This study was designed to explore effects tumor necrosis factor alpha (TNFα) PVN on AAR SNA rats with obesity-related hypertension (OH) induced by high-fat diet for 12 weeks. Renal (RSNA) mean arterial (MAP) were continuously...
Background Intracerebroventricular infusion of NaHS, a hydrogen sulfide (H2S) donor, increased mean arterial pressure (MAP). This study was designed to determine the roles H2S in paraventricular nucleus (PVN) modulating sympathetic activity and cardiac afferent reflex (CSAR) chronic heart failure (CHF). Methodology/Principal Findings CHF induced by left descending coronary artery ligation rats. Renal nerve (RSNA) MAP were recorded under anesthesia. CSAR evaluated RSNA responses epicardial...