A5027347488- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Extracellular vesicles in disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Apelin-related biomedical research
- Paraoxonase enzyme and polymorphisms
- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Biochemical effects in animals
- Circular RNAs in diseases
- Animal Nutrition and Physiology
- Dermatological and COVID-19 studies
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- Eicosanoids and Hypertension Pharmacology
- Sirtuins and Resveratrol in Medicine
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Redox biology and oxidative stress
- Cancer Research and Treatments
- Bacterial biofilms and quorum sensing
- Parvovirus B19 Infection Studies
- Thermoregulation and physiological responses
Nanjing Medical University
2020-2024
Target (United States)
2021
Southern Medical University
2014-2021
Foshan Maternity and Child Health Care Hospital
2019-2021
Fujian Medical University
2021
Union Hospital
2021
Nanfang Hospital
2019
First Affiliated Hospital of Xinjiang Medical University
2015
Xinjiang Agricultural University
2015
Xinjiang Medical University
2015
Although the combination of immune checkpoint blockades with high dose radiation has indicated potential co-stimulatory effects, consistent clinical outcome been yet to be demonstrated. Bulky tumors present challenges for treatment achieve rate tumor control due large sizes and normal tissue toxicities. As an alternative, spatially fractionated radiotherapy (SFRT) technique applied, in forms GRID or LATTICE therapy (LRT), safely treat bulky tumors. When used alone a single few fractions, LRT...
Clinical microbiology laboratories have to accurately identify clinical microbes. However, there can be failure in the identification of certain bacteria or fungi by phenotypic criteria sometimes. Therefore, ability 16S ribosomal DNA (16S rDNA) and internal transcribed spacer 2 (ITS2) sequencing these "difficult-to-identify" was assessed this study. Samples obtained from a teaching hospital over past three years were examined. The rDNA four standard strains, 18 common isolates, 47 amplified...
Superoxide and vascular smooth muscle cells (VSMCs) migration proliferation play crucial roles in the remodeling. Vascular remodeling contributes to development complications of hypertension. Rho family GTPase 3 (RND3 or RhoE), an atypical small Rho-GTPase, is known be involved cancer metastasis. However, RND3 superoxide production cardiovascular are unknown. Here, we uncovered critical attenuating production, VSMCs proliferation, hypertension its underline mechanisms. were isolated prepared...
Proliferation of vascular smooth muscle cells (VSMCs) greatly contributes to remodeling in hypertension. This study is determine the roles and mechanisms miR-135a-5p intervention attenuating VSMC proliferation spontaneously hypertensive rats (SHRs). MiR-135a-5p level was raised, while fibronectin type III domain-containing 5 (FNDC5) mRNA protein expressions were reduced VSMCs SHRs compared with those Wistar-Kyoto (WKYs). Enhanced inhibited by knockdown or inhibitor, but exacerbated mimic....
Excessive sympathetic activity and norepinephrine (NE) release play crucial roles in the pathogeneses of hypertension.Sympathetic fibers innervate adventitia rather than media arteries.However, NE adventitial fibroblasts (AFs) are unknown.This study investigated regulating AFs-derived extracellular vesicles (EVs) vascular smooth muscle cells (VSMCs) proliferation hypertension.Methods: AFs VSMCs were prepared from aorta Wistar-Kyoto rats (WKY) spontaneously hypertensive (SHR).AFs treated with...
Migration of vascular smooth muscle cells (VSMCs) is essential for reconstruction in hypertension and several diseases. Our recent study showed that extracellular vesicles derived from adventitial fibroblasts normal rats inhibited VSMC proliferation by delivering miR155-5p to VSMCs. It unknown whether inhibits cell migration oxidative stress VSMCs spontaneously hypertensive (SHR) angiotensin II (Ang II)-treated The purpose this was determine the role its underlying mechanisms. Primary were...
Oxidative stress and the migration of vascular smooth muscle cells (VSMCs) are important for remodeling in a variety diseases. miR-31-5p promotes cell colorectal cancer but inhibits renal carcinoma. However, whether is involved oxidative VSMC remains unknown. This study shows crucial roles migration, as well underlying mechanisms. Experiments were carried out primary VSMCs from aortic media Wistar–Kyoto rats (WKY) spontaneously hypertensive (SHR), A7r5 line. was assessed by NADPH oxidase...
Asprosin, a newly discovered hormone, is linked to insulin resistance. This study shows the roles of asprosin in vascular smooth muscle cell (VSMC) proliferation, migration, oxidative stress, and neointima formation injury.
Proliferation of vascular smooth muscle cells (VSMCs) plays a vital role in the progression remodeling and hypertension. Apelin-13 promotes VSMC proliferation normal rats. This study was designed to investigate roles apelin receptor (APJ) apelin-13 hypertension rats underlying mechanisms.Primary VSMCs were obtained from aorta Wistar-Kyoto rat (WKY) spontaneously hypertensive (SHR). The expressions APJ detected by Western bolt PCR, as well immunohistochemistry. evaluated with CCK-8 kit, PCNA...
The loss of effectiveness ischaemic preconditioning in protecting old hearts from ischaemia/reperfusion damage is thought to be due low sirtuin 1 levels hearts. We sought determine whether resveratrol (RES), an activator 1, would restore this protection that seen with young A Langendorff heart perfusion model was established 80 and adult rats test the effects hypoxic (HPC) and/or RES on preventing hypoxia–reperfusion (H/R) injury. were further tested by comparing HPC cell survival rate...
Abstract Hypertension is a leading risk factor for disease burden worldwide. Vascular contraction and remodeling contribute to the development of hypertension. Glutathione S-transferase P1 (Gstp1) plays several critical roles in both normal neoplastic cells. In this study, we investigated effect Gstp1 on hypertension as well vascular smooth muscle cell (VSMC) phenotypic switching. We identified higher level arteries VSMCs from hypertensive rats compared with normotensive first time. then...
Digestive enzyme activity is involved in the regulation of growth performance because digestive enzymes function to improve feed efficiency by digestion and turn modulate process nutrient metabolism. The objective this study was investigate differences activities expression transporters intestinal tract between Jinhua Landrace pigs explore potential breed-specificity absorption. pancreas segments digesta mucosa duodenum, jejunum, ileum were collected from 10 pigs, respectively. trypsin,...
Excessive sympathetic activation plays crucial roles in the pathogenesis of hypertension. Chemical stimulation renal afferents increases activity and blood pressure normal rats. This study investigated excitatory reflex (ERR) development hypertension spontaneously hypertensive rat (SHR). Experiments were performed Wistar-Kyoto (WKY) SHR aged at 4, 12, 24 weeks under anesthesia. Renal infusion capsaicin was used to stimulate afferents, thus, induce ERR. The ERR evaluated by changes...
The dorsal motor nucleus of the vagus (DMV) is known to control vagal activity. It unknown whether DMV regulates sympathetic activity and salusin-β in contributes autonomic nervous We investigated roles regulating sympathetic-parasympathetic balance its underline mechanisms. Microinjections were carried out hypothalamic paraventricular (PVN) male adult anesthetized rats. Renal nerve (RSNA), blood pressure heart rate recorded. Immunohistochemistry for reactive oxidative species (ROS)...
The formation and accumulation of foam cells within the arterial wall is main early event atherosclerosis. Vascular smooth muscle (VSMCs) are most abundant in human atherosclerotic lesions suggested to contribute atheroma cells. γ ‐glutamylcysteine ( ‐GC), as an immediate precursor glutathione, exhibits anti‐inflammatory antioxidant effects. However, effects ‐GC on plaques not yet clarified. Here, we display against ox‐LDL‐induced foamy VSMCs. Our results showed that apparently reduced total...
The effects on the baroreceptor reflexes and pulmonary of moderate immersion hypothermia (core temperature, 30.2 +/− 0.07 degrees C) have been investigated in decerebrate ferret. Baroreflex sensitivity was estimated from relationship between change cardiac interval systolic blood pressure following i.v. bolus injection phenylephrine. responses to phenylephrine ferrets were best fitted by two linear slopes with an initial shallow slope, a, followed a steeper b. slope or b increased...
The effects on baroreceptor reflexes of bilateral application the C fibre neurotoxin, capsaicin, to cervical vagi have been investigated in decerebrate ferrets. Baroreflex sensitivity was estimated from relationship between cardiac interval and systolic blood pressure following I.V. infusion phenylephrine. Control responses phenylephrine were fitted by two linear slopes with an initial shallow slope, a, followed a steeper b. Capsaicin abolished slope b resulting best single regression not...
Abstract Objectives Human parvovirus B19, the cause of fifth disease in children and transient arthropathy adults, could induce autoimmunity production autoantibodies. The aim this study is to explore relationship between B19 infection autoantibodies upregulation women children. Methods Of 512 our hospital 2016 2018, all cases simultaneously test anti-B19 IgM like anti-nuclear antibody, anti-Sm anti-double stranded DNA antibody were included study. Results Parvovirus significantly upregulate...