A5101794959- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Nutritional Studies and Diet
- Organ Transplantation Techniques and Outcomes
- Transcranial Magnetic Stimulation Studies
- Alcohol Consumption and Health Effects
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Motor Control and Adaptation
- Plant Virus Research Studies
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Dialysis and Renal Disease Management
- Artificial Intelligence in Healthcare
- Molecular Biology Techniques and Applications
- Neurological disorders and treatments
- Lung Cancer Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Health, Environment, Cognitive Aging
Sichuan University
2024-2025
Zhongda Hospital Southeast University
2024-2025
Southeast University
2025
State Key Laboratory of Digital Medical Engineering
2025
Gannan Medical University
2022-2024
Guangxi Medical University
2024
Genomics (United Kingdom)
2024
PetroChina Southwest Oil and Gas Field Company (China)
2024
First Affiliated Hospital of Gannan Medical University
2024
Wuhan University
2024
Chemotherapy is the preferred treatment for advanced stage gastric cancer (GC) patients and chemotherapy resistance major obstacle to effective therapy. Increasing evidence suggests that mesenchymal stem cells (MSCs) make important contributions development of drug resistance. However, underlying mechanism remains elusive. In this study, we discovered abundant MSCs in tumor tissues predicted a poor prognosis GC patients. promoted stemness chemoresistance through fatty acid oxidation (FAO)...
Abstract Background The role of lifestyle factors and their relative contributions to the development mortality cardio-renal-metabolic multimorbidity (CRMM) remains unclear. Methods A study was conducted with 357,554 UK Biobank participants. CRMM defined as coexistence two or three diseases (CRMDs), including cardiovascular disease (CVD), type 2 diabetes (T2D) chronic kidney (CKD). prospective examined associations individual combined scores (diet, alcohol consumption, smoking, physical...
Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for managing portal hypertension in cirrhotic patients, but the impact of post-TIPS overt hepatic encephalopathy (OHE) on survival remains controversial. While its effect short-term well-documented, long-term implications remain unclear. This study aims to investigate OHE mortality patients variceal bleeding, focusing timing and predictive value beyond first year post-TIPS. A multicenter, retrospective cohort...
Purpose To develop and validate a computational model for estimating hepatic venous pressure gradient (HVPG) based on CT angiographic images, termed virtual HVPG, to enable the noninvasive diagnosis of portal hypertension in patients with cirrhosis. Materials Methods In this prospective multicenter diagnostic trial (ClinicalTrials.gov identifier: NCT02842697), 102 consecutive eligible participants (mean age, 47 years [range, 21–75 years]; 68 men mean age 44 21–73 years] 34 women 52 24–75...
Abstract Background and aims The relationship between alcohol consumption age‐related diseases is inconsistent. Biological age (BA) serves as both a precursor predictor of diseases; however, longitudinal associations BA in middle‐aged older people remain unclear. We measured whether there was association drinking frequency pure intake with among people. Design setting participants This study involved two prospective cohort studies, set Southwestern China the United Kingdom. A total 8046 from...
Type 2 Diabetes Mellitus (T2DM), a prevalent metabolic disorder, often coexists with range of complications, retinopathy being particularly common. Recent studies have shed light on potential connection between diabetic (DR) and hepatic fibrosis, indicating possible shared pathophysiological foundation in T2DM. This study investigates the correlation fibrosis among individuals T2DM, as well evaluates diagnostic value DR for significant fibrosis. Our cross-sectional analysis incorporated 5413...
ABSTRACT Transjugular intrahepatic portosystemic shunt (TIPS) is a widely used surgery for portal hypertension. In clinical practice, the diameter of stent forming usually selected empirically, which will influence postoperative pressure. Clinical studies found that inappropriate pressure after TIPS responsible poor prognosis; however, there no scheme to predict Therefore, this study aims develop computational model applied ahead surgery. For purpose, patient‐specific 0‐3‐D multi‐scale...
Biological age serves as a common starting point for various age-related diseases and can be associated with wide range of cardiovascular outcomes. However, associations between biological (CBA) types disease (CVD) remain unclear. Analyzing 262,343 UK Biobank participants, we constructed CBA based on composite biomarkers using the Klemera-Doubal method (denoted KDM-CBA). We measured KDM-CBA acceleration difference chronological age. then examined 17 CVD Cox proportional hazard models. used...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health concern that necessitates early screening and timely intervention to improve prognosis. The current diagnostic protocols for MASLD involve complex procedures in specialised medical centres. This study aimed explore the feasibility of utilising machine learning models accurately screen large populations based on combination essential demographic clinical characteristics. A total 10,007 outpatients who...
Gene/genome dosage balance is an essential evolutionary mechanism for organisms to ensure a normal function, but the underlying causes of dosage-imbalance regulation remain poorly understood. Herein, serial Brassica hybrids/polyploids (AC, AAC, CCA, CCAA) with different copies A and C subgenomes from same two parents rapa oleracea were synthesized investigate effects genome dosages on gene expressions interactions by using RNA-Seq. The expression changes A- C-subgenome genes consistent...
The study was conducted to investigate the difference between Han Chinese and Caucasians on various parameters measured from responses transcranial magnetic brain stimulation (TMS). Sixteen subjects were studied in each group. A circular coil at vertex used for stimulation, whilst recording surface electromyograms right first dorsal interosseous. In passive state, motor-evoked potential (MEP) threshold, MEP recruitment, short-interval intracortical inhibition (SICI) facilitation measured....
The expression of integrin‑linked kinase (ILK) has been reported to be involved in the regulation integrin‑mediated processes, including cancer cell proliferation, migration and invasion. Previous studies have demonstrated that inhibition ILK may an underlying approach for treating cancer. However, whether knock down affects growth apoptosis lung cells remains elucidated. Importantly, downregulation increases sensitivity cisplatin amplifies also In present study, was mediated by...
With the increasing number of maintenance hemodialysis (MHD) patients, growing attention has been paid to quality care. Strengthening care preparedness family caregivers is essential improving nursing quality. The purpose this study explore level MHD patients and its influencing factors, so as provide guidance for development targeted interventions. A total 237 were recruited from room two tertiary hospitals in Wuhan using Convenience sampling method. They surveyed by general data...
Transcranial Magnetic Stimulation (TMS) is an excellent and non-invasive technique for studying the human brain. Accurate placement of magnetic coil required by this in order to induce a specific cortical activity. Currently, manually held most stimulation procedures, which does not achieve precise clinical evaluation procedure. This paper proposes robotic TMS system resolve these problems as robot has locating holding capabilities. The proposed can track real-time subject's head position...
Abstract Dysregulations in transcription factors (TFs) and their genetic products play important roles tumorigenesis, tumor progression metastasis. However, prognostic value of the transcriptional regulatory networks different cancers has not been investigated depth. The purpose our study was to identify validate a potential predictive signature that combines TFs eight solid tumors. We used bioinformatics analysis MET Transcriptional Regulator (MACC1) Serine Peptidase Inhibitor Kunitz Type 1...
We reported a case of locally advanced anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC) patient who received neoadjuvant alectinib therapy. Enhanced computed tomography (CT) scan was performed after the first cycle therapy to evaluate efficacy alectinib. Surprisingly, tumor shrunk 42.2% one treatment. Partial remission (PR) achieved without any side effects, although stage didn't degrade. Then right upper lobectomy and mediastinal lymph node dissection by video...
Endoscopic injection sclerotherapy is an effective method for treating esophageal variceal hemorrhage [1] [2]. However, owing to the rapid loss of sclerosing agent, overall effect weakened. Therefore, increasing residence time agent remains a focal point current investigations. The present study reported case treated with novel technology termed balloon-assisted endoscopic sclerotherapy.