A5068377881- Nutritional Studies and Diet
- Ionic liquids properties and applications
- Dietary Effects on Health
- Liver Disease Diagnosis and Treatment
- Chemical and Physical Properties in Aqueous Solutions
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Obesity, Physical Activity, Diet
- Crystallization and Solubility Studies
- Cancer, Lipids, and Metabolism
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- Birth, Development, and Health
- Diet and metabolism studies
- Electrocatalysts for Energy Conversion
- Health, Environment, Cognitive Aging
- Nanomaterials for catalytic reactions
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Consumer Attitudes and Food Labeling
- Ferroptosis and cancer prognosis
- RNA and protein synthesis mechanisms
- Acupuncture Treatment Research Studies
- Ovarian cancer diagnosis and treatment
- Air Quality and Health Impacts
Sichuan University
2016-2025
Xian Center for Disease Control and Prevention
2024-2025
Nanjing Drum Tower Hospital
2025
State Key Laboratory of Biotherapy
2019-2024
Renji Hospital
2024
Shanghai Cancer Institute
2024
West China Hospital of Sichuan University
2022-2024
Guangdong Pharmaceutical University
2024
State Key Laboratory of Oral Diseases
2022
Bristol-Myers Squibb (United States)
2014-2022
Electrocatalytic transfer alkyne semi‐hydrogenation with H2O as hydrogen source is industrially promising for selective electrosynthesis of high value‐added alkenes while inhibiting byproduct alkanes. Although great achievements, their development has remarkably restricted by designing atomically sophisticated electrocatalysts. Here, we reported single‐crystalline mesoporous copper nanoplates (meso‐Cu PLs) a robust yet highly efficient electrocatalyst alkene from reaction in H2O. Anisotropic...
Background In Western developed countries, food-based dietary patterns have been associated with the risk of cardiometabolic diseases, but little is known about such associations in less ethnic minority regions (LEMRs), where disease burden growing rapidly and food differ substantially.Methods Between May 2018 September 2019, we recruited 99556 participants aged 30-79 years from China Multi-Ethnic Cohort (CMEC) Study. We measured habitual intake validated frequency questionnaire (FFQ) then...
The biological aging process can be modified through lifestyle interventions to prevent age-related diseases and extend healthspan. However, evidence from population-based studies on whether tea consumption could delay the in humans remains limited.This study included 7931 participants aged 30-79 years China Multi-Ethnic Cohort (CMEC) Study 5998 37-73 UK Biobank (UKB) who participated both baseline first follow-up surveys. Tea information was collected questionnaires. Biological age (BA)...
Electrocatalytic transfer alkyne semi‐hydrogenation with H2O as hydrogen source is industrially promising for selective electrosynthesis of high value‐added alkenes while inhibiting byproduct alkanes. Although great achievements, their development has remarkably restricted by designing atomically sophisticated electrocatalysts. Here, we reported single‐crystalline mesoporous copper nanoplates (meso‐Cu PLs) a robust yet highly efficient electrocatalyst alkene from reaction in H2O. Anisotropic...
The purpose of this study was to develop a self-microemulsifying drug delivery system (SMEDDS) improve the oral bioavailability Berberine hydrochloride (BBH), an important bioactive compound from Chinese Medicines with poor water solubility. Pseudoternary phase diagrams were constructed using oil, surfactant and co-surfactant types identify efficient self-microemulsification region. SMEDDS characterized by morphological observation, droplet size, zeta-potential determination, stability, in...
A massive intronic hexanucleotide repeat (GGGGCC) expansion in C9ORF72 is a genetic origin of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recently, C9ORF72, together with SMCR8 WDR41, has been shown to regulate autophagy function as Rab GEF. However, the precise remains unclear. Here, we report cryogenic electron microscopy (cryo-EM) structure human C9ORF72-SMCR8-WDR41 complex at resolution 3.2 Å. The reveals dimeric assembly heterotrimer C9ORF72-SMCR8-WDR41....
Ferroptosis is a recently discovered form of regulated cell death characterized by its distinct dependence on iron and the peroxidation lipids within cellular membranes. plays crucial role in physiological pathological situations has attracted attention numerous scientists. suppressive protein 1 (FSP1) one main regulators that negatively regulates ferroptosis through GPX4-independent FSP1-CoQ10-NAD(P)H axis potential therapeutic target for ferroptosis-related diseases. However, crystal...
Abstract Background and aims The relationship between alcohol consumption age‐related diseases is inconsistent. Biological age (BA) serves as both a precursor predictor of diseases; however, longitudinal associations BA in middle‐aged older people remain unclear. We measured whether there was association drinking frequency pure intake with among people. Design setting participants This study involved two prospective cohort studies, set Southwestern China the United Kingdom. A total 8046 from...
Significance NOD-like receptors (NLRs) are traditionally recognized as key surveillance pattern recognition (PRRs) during innate immune regulation. Several NLRs exhibit highly restricted expression in mammalian germline, where their physiological functions largely unknown. Here we report that Nlrp14, an NLR specifically expressed testis and ovary, plays a critical role regulating germ cell differentiation reproduction. Nlrp14 deficiency led to decreased primordial cell-like (PGCLC) vitro...
Background: Biological aging exhibits heterogeneity across multi-organ systems. However, it remains unclear how is lifestyle associated with overall and organ-specific which factors contribute most in Southwest China. Methods: This study involved 8396 participants who completed two surveys from the China Multi-Ethnic Cohort (CMEC) study. The healthy index (HLI) was developed using five factors: smoking, alcohol, diet, exercise, sleep. comprehensive biological ages (BAs) were calculated...
BACKGROUND A significant association between increased age and an risk of metachronous gastric cancer (MGC) following curative endoscopic submucosal dissection (ESD) has previously been reported. AIM To determine factors for the occurrence early (EGC) in elderly individuals. METHODS This retrospective cohort study comprised 653 patients (aged ≥ 65 years) who underwent ESD EGC January 2014 June 2020 at Nanjing Drum Tower Hospital. Comprehensive analyses were conducted to compare lifestyle...
The surface protein P113 serves as a membrane-anchored that tethers the Plasmodium falciparum RH5 complex, including its associated partners CyRPA and RIPR, to parasite surface. This anchoring mechanism ensures proper localization stabilization of RH5, facilitating critical interaction with host erythrocyte receptor basigin during invasion. Here, helical-rich domain (residues 311–679) from species was expressed, purified crystallized elucidate structural functional characteristics....
A novel magnetic ionic liquid aqueous two-phase systems (MILATPs) has been developed, based on a series of novelly synthesized guanidinium-based liquids.
Abstract Early diagnosis of liver fibrosis is critical for early intervention and prognosis various chronic diseases. Conventional repeated histological assessment impractical due to the associated invasiveness. In current study, we evaluated circulating miR-185 as a potential biomarker predict initiation progression fibrosis. We found that was significantly up-regulated in blood specimens from patients with HBV-liver rats fibrosis, levels were correlated progression, but not different viral...
Metabolically healthy obesity (MHO) might be an alternative valuable target in treatment. We aimed to assess whether Mediterranean (aMED) diet and Dietary Approaches Stop Hypertension (DASH) were favourably associated with MHO phenotype a Chinese multi-ethnic population. conducted this cross-sectional analysis using the baseline data of China Multi-Ethnic Cohort study that enrolled 99 556 participants from seven diverse ethnic groups. Participants self-reported cardiometabolic diseases...
Ordered intermetallic nanocatalysts supported on high-surface-area skeletons are of great importance in catalysis and have disclosed notable catalytic activity stability that remarkably better than their random alloy counterparts. Ultrafine synthetically challenging, especially for universal scaled-up synthesis, because inevitable sintering phase separation under high temperatures promote atomic alloying ordering. Herein, a solid-phase method is reported synthesizing ultrafine with uniform...
Abstract As one kind of functionalized green medium, chiral ionic liquids (CILs) have been widely applied in fields asymmetric catalysis, enantioseparation, and so on. In this study, four kinds amino acid–based CILs were synthesized by using trimethylamine, N‐methylpyrrolidine, N‐methylimidazole, tropine as cationic nucleus, respectively. Then their specific optical rotation solubility common solvents determined for further resolution application. The effect different cations these was...
To investigate the influence of pH dissolution medium on immediate release 850 mg metformin hydrochloride tablets.A traditional wet granulation method was used to manufacture tablets with or without a disintegrant. Tablet conducted using USP apparatus I at 100 rpm.In spite its pH-independent high solubility, dissolved significantly slower in 0.1 N HCl (pH 1.2) and 50 mM 4.5 acetate buffer compared 6.8 phosphate buffer, USP. Metformin API compressed into round 1200 disk showed similar trend....
Massive expansions of the hexanucleotide in C9orf72 are primary genetic origins familial amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD). Current studies have found that this repeat sequence participates disease process by producing neurotoxic substances reducing level protein; however, progress functional study is slow. Recently, a stable complex, consisting C9orf72, SMCR8, WDR41, has been implicated regulating membrane trafficking macroautophagy. We reported...