A5103062571- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Acute Myocardial Infarction Research
- Obesity, Physical Activity, Diet
- Healthcare Systems and Reforms
- Health Systems, Economic Evaluations, Quality of Life
- Nutritional Studies and Diet
- Health Promotion and Cardiovascular Prevention
- Flame retardant materials and properties
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Photopolymerization techniques and applications
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Health disparities and outcomes
- Global Public Health Policies and Epidemiology
- Marine Biology and Environmental Chemistry
- Cardiac Health and Mental Health
- Epoxy Resin Curing Processes
- Polymer Surface Interaction Studies
- Chronic Disease Management Strategies
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Physical Activity and Health
- Healthcare Systems and Practices
Wuhan University of Technology
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Southwest Jiaotong University
2023-2025
Peking University
2013-2025
Ningbo Medical Center Lihuili Hospital
2022-2025
Taizhou Central Hospital
2024
Taizhou University
2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2023
Crystal structures of the murine cytokine-inducible nitric oxide synthase oxygenase dimer with active-center water molecules, substrate l -arginine ( -Arg), or product analog thiocitrulline reveal how dimerization, cofactor tetrahydrobiopterin, and -Arg binding complete catalytic center for synthesis essential biological signal cytotoxin oxide. Pterin refolds central interface region, recruits new structural elements, creates a 30 angstrom deep channel, causes 35° helical tilt to expose heme...
It is estimated that 4 million deaths are due to cardiovascular diseases each year in China. Comprehensive understanding about modifiable risk factors and how the differs across regions needed inform public health policies. We aimed examine geographical profile of disease China.In this study, we analysed data from a nationwide, population-based screening project, which covered 152 rural counties 100 urban districts 31 provinces Between Sept 1, 2015, Nov 30, 2019, standardised measurements...
Introduction Collection of high-quality data from large populations is considered essential to generate knowledge that critical an era precision medicine. Cardiovascular disease (CVD) a leading cause mortality in China and suitable focus initiative discover factors would improve our ability assess modify individual risk. Methods analysis The pilot phase PEACE (Patient-centered Evaluative Assessment Cardiac Events) Million Persons Project being conducted during 2014–2015 four provinces across...
China has seen a burgeoning epidemic of obesity in recent decades, but few studies reported nationally on across socio-demographic subgroups. We sought to assess the prevalence and associations nationwide.We assessed overall (body mass index ≥28 kg/m2) abdominal (waist circumference ≥85/90 cm for women/men) among 2.7 million community-dwelling adults aged 35 75 years PEACE Million Persons Project from 2014 2018 quantified using multivariable mixed models.Age-standardized rates were 14.4%...
To assess the different educational inequalities in mortality among generations born between 1940 and 1979 China, to investigate role of socioeconomic, behavioural, metabolic factors as potential contributors reduction inequalities.Nationwide, population based, prospective cohort study.The ChinaHEART (China Health Evaluation And risk Reduction through nationwide Teamwork) project all 31 provinces mainland China.1 283 774 residents aged 35-75 years, divided into four separate cohorts 1940s,...
The nitric oxide synthases (NOS) are the only heme-containing enzymes that require tetrahydrobiopterin (BH4) as a cofactor. Previous studies indicate fully reduced (i.e., tetrahydro) form of BH4 can support NO synthesis. Here, we characterize pterin-free inducible NOS (iNOS) and iNOS reconstituted with eight different tetrahydro- or dihydropterins to elucidate how changes in pterin side-chain structure ring oxidation state regulate iNOS. Seven enzyme properties important for catalysis...
Background Heart failure (HF) is an emerging epidemic in China and accounts for significant healthcare resource utilization the inpatient setting. To create evidence-based, life-saving, cost-saving hospitalization systems, first step to characterize contemporary national landscape of HF care. Methods Results In PEACE 5r-HF study (China Patient-centered evaluative Assessment Cardiac Events Retrospective Study Failure), we used 2-stage random sampling a nationally representative cohort 10 004...
Abstract Background Healthy lifestyle behaviours are effective means to reduce the burden of diseases. This study was aimed fill knowledge gaps on distribution, associated factors, and potential health benefits mortality four healthy in China. Methods During 2015–2019, participants aged 35–75 years from 31 provinces were recruited by China PEACE Million Persons Project. Four investigated our study, including non-smoking, none or moderate alcohol use, sufficient leisure time physical activity...
Journal Article Cohort Profile: ChinaHEART (Health Evaluation And risk Reduction through nationwide Teamwork) Get access Runsi Wang, Wang National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Medications, Fuwai Hospital, Chinese Academy Medical Sciences and Peking Union College, Beijing, People's Republic China Search other works by this author on: Oxford Academic PubMed Google Scholar Yang Yang, Jiapeng Lu, Lu Jianlan Cui, Cui Wei Xu, Xu Lijuan Song, Song...
The oxygenase domain (amino acids 1−498) of inducible nitric oxide synthase (iNOSox) is a hemeprotein that binds l-arginine (l-Arg) and tetrahydrobiopterin (H4B). During NO synthesis, the heme iron must bind activate O2, but it also self-generated to form an inactive complex. To better understand how l-Arg H4B affect function in iNOSox, we utilized stopped-flow spectroscopy study reactivity with CO properties resulting complexes. binding ferrous ferric (NO only) iNOSox subsequent complex...
<h3>Importance</h3> Patients who survive acute myocardial infarction (AMI) have a high risk of subsequent major cardiovascular events. Efforts to identify factors for recurrence primarily focused on the period immediately following AMI admission. <h3>Objectives</h3> To and develop evaluate model that predicts 1-year events after AMI. <h3>Design, Setting, Participants</h3> Prospective cohort study. with (n = 4227), aged 18 years or older, discharged alive from 53 acute-care hospitals across...
Background Characterizing and assessing the prevalence, awareness, treatment patterns of patients with isolated diastolic hypertension ( IDH ) can generate new knowledge highlight opportunities to improve their care. Methods Results We used data from China PEACE (Patient‐centered Evaluative Assessment Cardiac Events) Million Persons Project, which screened 2 351 035 participants aged 35 75 years between 2014 2018. was defined as systolic blood pressure <140 ≥90 mm Hg; awareness...
Since 2010, China has made vast financial investments and policy changes to the primary care system. We aimed assess how hypertension awareness, treatment, control might be used quality of systems, which reflect outcomes public health services medical care.We The Patient-centred Evaluative Assessment Cardiac Events Million Persons Project, a government-funded project that focuses on cardiovascular disease risk in China. linked institution characteristics were captured survey between 2016...
Abstract Purpose Large language models (LLMs) are pivotal in artificial intelligence, demonstrating advanced capabilities natural understanding and multimodal interactions, with significant potential medical applications. This study explores the feasibility efficacy of LLMs, specifically ChatGPT-4o Claude 3-Opus, classifying thyroid nodules using ultrasound images. Methods included 112 patients a total 116 nodules, comprising 75 benign 41 malignant cases. Ultrasound images these were...
With the increasing popularity of elastomers in industry and daily life, their high performance functionality have attracted widespread attention. However, it is a great challenge for them to possess both mechanical properties excellent healing recovery capabilities due limitations preparation methods intrinsic microstructure elastomers. In this study, strategy ice-controlled interfacial stepwise cross-linking was proposed prepare waterborne polyurethane-based with ultrahigh-density hydrogen...
<h3>Importance</h3> Return to work is an important indicator of recovery after acute myocardial infarction. Little known, however, about the rate returning within year infarction in China, as well factors associated with <h3>Objectives</h3> To determine return 12 months infarction, classify reasons why patients did not work, and identify patient work. <h3>Design, Setting, Participants</h3> This prospective cohort study, conducted 53 hospitals across 21 provinces identified 1566 who were...
China has been undergoing a rapid urbanisation. There are substantial disparities between old and new urban citizens in access to health care. We aimed compare cardiovascular disease prevention death risks among four distinct groups.Urban residents aged 35-75 years living 96 prefecture-level cities from 31 provinces mainland were enrolled the national population-based cohort Patient-centered Evaluative Assessment of Cardiac Events Million Persons Project. They categorised into groups by...
Abstract Large‐tow carbon fiber fabrics generate considerable structured background texture noise in infrared thermographic inspections due to their nonuniform thermal properties. The presence of such poses notable challenges the reliable and precise detection defects. To address this issue, article proposes a defect method that integrates frame averaging difference (FAD) algorithm principal component analysis (PCA). utilizes FAD remove nontime‐varying noise, improving contrast‐to‐noise...