A5100442212- Prostate Cancer Treatment and Research
- Cell Adhesion Molecules Research
- Sexual function and dysfunction studies
- Urinary Bladder and Prostate Research
- Cancer-related molecular mechanisms research
- Hormonal and reproductive studies
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Sexuality, Behavior, and Technology
- MicroRNA in disease regulation
- Sexual Differentiation and Disorders
- Immunotherapy and Immune Responses
- Sperm and Testicular Function
- RNA Research and Splicing
- Urological Disorders and Treatments
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Ovarian function and disorders
- RNA modifications and cancer
- Pharmacology and Obesity Treatment
Yantaishan Hospital
2017-2025
Binzhou University
2024
Binzhou Medical University
2024
Guangzhou Medical University
2019-2024
Hebei University of Engineering
2024
Capital Medical University
2017-2023
Beijing Chao-Yang Hospital
2019-2023
Nanjing Medical University
2016-2022
Beijing Friendship Hospital
2020-2022
Second Hospital of Anhui Medical University
2022
Definitive diagnosis and selection of effective treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are frustrations encountered frequently by urology care providers in their practice. Knowledge etiology pathophysiology is not sufficient therapeutic guidelines have yielded acceptable outcomes prognoses both patients providers. The authors present updated perspectives on CP/CPPS, including definition, diagnosis, treatment, prognosis, based literature review clinical...
The purpose of this study was to describe the first metabolic profile human sperm cells through application an untargeted platform based on gas chromatography-mass spectrometry (GC-MS). Sperm cell samples from patients diagnosed with idiopathic asthenozoospermia (n = 30) and healthy subjects were analyzed using a nontargeted metabolomics method GC-MS spectroscopy. mass spectrometric data collected multivariate univariate analyses identify metabolites related asthenozoospermia. By metabolomic...
Long noncoding RNAs (lncRNAs) have been regarded as modulators of neurodegenerative diseases. Here, we addressed the role lncRNA miR-17-92a-1 cluster host gene (MIR17HG) in Parkinson's disease (PD). C57BL/6 mice and SH-SY5Y cells were intervened with 6-hydroxydopamine (6-OHDA) to set up PD models vivo vitro. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was implemented compare expression MIR17HG miR-153-3p. Cell viability apoptosis estimated by...
This study was proposed to compare the clinical effectiveness of mini-tract percutaneous nephrolithotomy (MPCNL) with standard-tract (SPCNL) and verify whether MPCNL is associated both higher renal pelvic pressure (RPP) incidence postoperative fever. A total 228 patients kidney stone were randomly allocated group (n=114) SPCNL (n=114). Both intraoperative indexes along complications compared between two treatment groups. RPP measured using a baroreceptor which connected an open-ended...
The cells' ability to proliferate in response growth factor stimulation is significantly altered during cancer progression. To investigate the mechanisms underlying these alterations prostate cancer, role and expression of beta1A integrin type 1 insulin-like receptor (IGF-IR), known contribute cell proliferation transformation, were analyzed. Using small interfering RNA oligonucleotides down-regulate beta1A, we show that required for IGF-IR-mediated anchorage-independent growth. In vivo,...
The aberrant expression of microRNAs (miRs) has been identified to serve a crucial role in tumor progression. present study aimed evaluate the miR-126 human prostate cancer (PCa). Firstly, tissues and cell lines was analyzed. A luciferase reporter assay rescue were performed, which ADAM metalloproteinase domain 9 (ADAM9) as target gene miR-126. Subsequently, Kaplan-Meier log-rank analyses used investigate association between ADAM9 PCa prognosis. results revealed that significantly...
Abstract: The evolutionarily conserved genes that encode the tripartite motif (TRIM) protein family are involved in various biological processes, including cellular immunity, inflammatory reaction, antiviral activity, and tumor progression. One member of this family, Trim59, has been reported as a novel biomarker for occurrence progression multiple human carcinomas, such lung cancer, gastric cervical osteosarcoma. However, little is known about relationship between Trim59 bladder...
Antisense long noncoding RNAs (lncRNAs) are reported to play a regulating role in carcinogenesis of various human malignancies. However, the function lncRNAs and their underlying mechanism renal cell carcinoma (RCC) is still unknown. The aims this study investigate expression lncRNA BX357664 RCC explore its lines. As result, was downregulated according previous microarray analysis qualitative real-time polymerase chain reaction. After upregulation BX357664, reduced migration, invasion,...
Abstract Background Laryngeal squamous cell carcinoma (LSCC) is considered to be a common malignancy of the head and neck with poor prognosis for its late diagnosis, metastasis recurrence. Growing evidence demonstrates that dysregulation miR-29c-3p (microRNA-29c-3p) plays an important role in various tumor processes. Our study investigates expression LSCC analyzes correlation clinicopathologic parameters prognosis. Methods The hsa-miR-29c-3p tissues adjacent normal laryngeal was detected 96...
Abstract Androgen receptor signaling fuels prostate cancer and is a major therapeutic target. However, mechanisms of resistance to androgen ablation are not well understood. Here, using mouse model, Ptenpc−/−, carrying epithelial-specific Pten deletion, we show that the αvβ6 integrin required for tumor growth in vivo castrated as noncastrated mice. We describe novel pathway couples cell surface via activation JNK1 causes increased nuclear localization activity receptor. This downstream...
Knowledge is limited about the lifetime risk of chronic pelvic pain syndrome (CPPS) occurrence in Chinese middle-aged males and prognosis CPPS patients with without treatment. Noninstitutionalized aged 40 to 81 years were enrolled this study from a total 76 local communities across 30 provinces China. Information CPPS, symptom relief, previous treatment was collected. Based on completed answers specific questions self-reported physician-diagnosed 25.3% (1,091 out 4,315) years. Over 77% had...
Objective To investigate the effect of early-life unilateral testicular torsion on adult male fertility. Methods Clinical information was collected for 122 patients who had experienced at a median age 15.5 years. The recent pregnancy rate and time to by patients’ female partners were assessed structured interviews. Data analyzed chi-squared test Student’s t-test. Results Seventy-two with met criteria inclusion in our analyses; 49 undergone orchiectomy, while 23 surgical...
Lactate dehydrogenase C is an isoenzyme of lactate and a member the cancer–testis antigens family. In this study, we aimed to investigate expression functional role its basic mechanisms in renal cell carcinoma. First, total 133 cases carcinoma samples were analysed tissue microarray, Kaplan–Meier survival curve analyses performed correlation between progression. protein levels messenger RNA significantly upregulated tissues, patients with positive had shorter progression-free survival,...
Abstract This study aimed to explore the association between methylation status of VDAC2 gene promoter region and idiopathic asthenospermia (IAS). Twenty-five IAS patients 27 fertile normozoospermia (NZ) were involved. GC-2spd cells treated with different concentrations 5-aza-2′-deoxycytidine (5-Aza-CdR) for 24 h 48 h. qRT-PCR was conducted reveal whether or not expression regulated by methylated modification. A dual-luciferase activity detection used verify in cells. Bisulphite genomic...
The calpain 2 (CAPN2) is upregulated in various malignant carcinomas. Previous studies have reported that CAPN2 functioned as an oncogenic factor human cancers. However, its clinical role and potential effects on cell metastasis proliferation renal carcinoma (RCC) remain unknown. In this study, we evaluated the mRNA protein levels of RCC specimens, matched normal lines using quantitative Real-time PCR (RT-PCR) western blot. Immunohistochemistry 74 tissues a tissue microarrays (TMAs) kidney...
// Jundong Zhu 1, * , Chao Liang Yibo Hua Chenkui Miao 1 Jianzhong Zhang Aiming Xu Kai Zhao Shouyong Liu Ye Tian Huiyu Dong Pu Li Shifeng Su Qin and Zengjun Wang Department of Urology, The First Affiliated Hospital Nanjing Medical University, Nanjing, China These authors contributed equally to this work Correspondence to: Wang, email: zengjunwang@njmu.edu.cn Qin, 13776678978@163.com Keywords: CD82/KAI1, tetraspanin, migration/invasion, TGF-β1/Smad signaling, renal cell carcinoma Received:...