A5101799692- Genetic Associations and Epidemiology
- Cancer Risks and Factors
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Cardiac Imaging and Diagnostics
- Ovarian cancer diagnosis and treatment
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Birth, Development, and Health
- vaccines and immunoinformatics approaches
- Pharmacological Effects of Natural Compounds
- Clostridium difficile and Clostridium perfringens research
- Whipple's Disease and Interleukins
- Osteoarthritis Treatment and Mechanisms
- Ultrasound and Hyperthermia Applications
- COVID-19 and healthcare impacts
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Endometriosis Research and Treatment
- Bone health and osteoporosis research
- Fire dynamics and safety research
- Folate and B Vitamins Research
West China Medical Center of Sichuan University
2022-2025
Sichuan University
2024
First Hospital of Jilin University
2024
Jilin University
2024
Wuhan University
2009
Abstract Background Although physical activity (PA) has been linked to cognitive health, the nuanced relationships between different dimensions of PA and impairment remain inconclusive. This study investigated associations late-life levels, midlife-to-late-life patterns, in Chinese older adults, considering potential moderation by apolipoprotein E ( APOE ) ε4 genotype. Methods We analyzed baseline data from 6,899 participants (median age 68 years, 55.78% female) West China Health Aging...
Diabetes and obesity are established risk factors for heart failure(HF). Although the TyG (triglyceride-glucose) index serves as a sensitive marker identifying insulin resistance, there is lack of comprehensive evidence regarding whether its integration with indices can enhance predictive capacity HF. This prospective cohort study designed to explore correlation between in conjunction (TyG-body mass index, or TyG-BMI; TyG-waist circumference, TyG-WC; circumference-to-height ratio, TyG-WHtR)...
Background The relationship between type 2 diabetes mellitus (T2DM) and gallstone disease (GSD) have been incompletely understood. We aimed to investigate their phenotypic genetic associations evaluate the biological mechanisms underlying these associations. Methods first evaluated association T2DM GSD using data from UK Biobank (n>450,000) a prospective observational design. then conducted analyses summary statistics meta-analysis of genome-wide studies T2DM, with without adjusting...
Although the negative association of tobacco smoking with osteoporosis is well-documented, little known regarding shared genetic basis underlying these conditions. In this study, we aim to investigate a architecture between and heel estimated bone mineral density (eBMD), reliable proxy for osteoporosis. We conducted comprehensive genome-wide cross-trait analysis identify correlation, pleiotropic loci causal relationship eBMD, leveraging summary statistics hitherto largest studies in European...
Abstract Background Previous Mendelian randomization (MR) studies on obesity and risk of breast cancer adopted a small number instrumental variables focused mainly the crude total effect. We aim to investigate independent causal effect susceptibility, considering distribution fat, covering both early late life. Methods Using an enlarged set female-specific genetic variants associated with adult general [body mass index (BMI)] abdominal [waist-to-hip ratio (WHR) without adjustment for BMI,...
ABSTRACT Physical inactivity and sedentary behavior are associated with higher risks of age‐related morbidity mortality. However, whether they causally contribute to accelerating biological aging has not been fully elucidated. Utilizing the largest available genome‐wide association study (GWAS) summary data, we implemented a comprehensive analytical framework investigate associations between genetically predicted moderate‐to‐vigorous leisure‐time physical activity (MVPA), leisure screen time...
Adult height measures the complete growth of an individual and influences development cardiovascular diseases (CVD). Despite recent within-sibling studies suggesting minimal impact from environmental confounders, biological mechanisms underlying height-CVD relationship remain elusive. Leveraging large-scale UK biobank dataset summary statistics latest genome-wide association (GWAS), we re-evaluated effect on 8 major CVD subtypes. Phenotypic associations were determined by Cox proportional...
Abstract Background Macro and micronutrients may play an important role in osteoporosis development; however, observational studies have yielded inconsistent results. Clarifying these associations is vital to the development of nutritional recommendations aimed at preventing osteoporosis. Methods Utilizing largest available genome-wide association study (GWAS) summary statistics date, we performed a two-sample Mendelian randomization (MR) analysis investigate causal effects energy-adjusted...
To establish a universally applicable logistic risk prediction model for diabetes mellitus type 2 (T2DM) in the middle-aged and elderly populations based on results of Meta-analysis, to validate confirm efficacy using follow-up data medical check-ups National Basic Public Health Service.
Little is known regarding the shared genetic influences underlying observed phenotypic association between chronotype and breast cancer in women. Leveraging summary statistics from hitherto largest genome-wide study conducted each trait, we investigated correlation, pleiotropic loci, causal relationship of with overall cancer, its subtypes defined by status oestrogen receptor. We identified a negative genomic correlation (
Abstract Physical inactivity and sedentary behavior are associated with higher risks of age-related morbidity mortality. However, whether they causally contribute to accelerating biological aging has not been fully elucidated. Utilizing the largest available genome-wide association study (GWAS) summary data, we implemented a comprehensive analytical framework investigate causal relationships between moderate-to-vigorous leisure-time physical activity (MVPA), leisure screen time (LST), four...
ABSTRACT Background Little is known regarding the long-term adverse effects of COVID-19 on female-specific cancers due to restricted length observational time, nor shared genetic influences underlying these conditions. Methods Leveraging summary statistics from hitherto largest genome-wide association studies conducted in each trait, we performed a comprehensive cross-trait analysis investigate architecture and putative associations between with three main cancers: breast cancer (BC),...
While a higher level of physical activity (PA) is inversely associated with breast cancer (BC) risk, the health benefits daily steps on obesity-related BC biomarkers remain unclear. We aimed to understand associations changes in step counts levels five during two-year follow-up. In total, 144 non-cancer women (47.96 ± 5.72) were observed both 2019 and 2021. A structured questionnaire, fasting blood samples collected before (t0, 2019) after (t1, 2021). Levels (IGF-binding proteins 3,...