A5100756033- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bone Tissue Engineering Materials
- Dental Erosion and Treatment
- Dental Radiography and Imaging
- Dental Research and COVID-19
- Endodontics and Root Canal Treatments
- Orthodontics and Dentofacial Orthopedics
- Mechanical stress and fatigue analysis
- Periodontal Regeneration and Treatments
- Advanced materials and composites
- Dental Trauma and Treatments
- Anatomy and Medical Technology
- Metal and Thin Film Mechanics
- Electrical Contact Performance and Analysis
- Temporomandibular Joint Disorders
- Laser Applications in Dentistry and Medicine
- Osteoarthritis Treatment and Mechanisms
- Additive Manufacturing and 3D Printing Technologies
- Orthopedic Surgery and Rehabilitation
- Bone Metabolism and Diseases
- Titanium Alloys Microstructure and Properties
State Key Laboratory of Oral Diseases
2016-2025
Sichuan University
2016-2025
Southwest Jiaotong University
2005-2025
West China Hospital of Sichuan University
2016-2025
Shanghai Jiao Tong University
2025
Tianjin University of Traditional Chinese Medicine
2022-2025
Stomatology Hospital
2023-2024
Kangda College of Nanjing Medical University
2023
Nanjing Medical University
2023
Shanghai University of Engineering Science
2021-2022
The application of nano-hydroxyapatite (HA) in the repair early caries lesion has received considerable attention. Neither effects size HA nor effective pH range nano-HA on remineralization have been investigated comprehensively, and protective mechanism is still open for debate. To address these factors, effect demineralized bovine enamel under cycling conditions through surface cross-sectional microhardness (CSMH) tests polarized light microscopy (PLM). percentage recovery integrated...
By removing a part of the structure, tooth preparation provides restorative space, bonding surface, and finish line for various restorations on abutment. Preparation technique plays critical role in achieving optimal result preparation. With successful application microscope endodontics >30 years, there is full expectation microscopic dentistry. However, as relatively little progress has been made dentistry prosthodontics, following assumptions have proposed: Is it suitable to choose under...
Abstract Polyetheretherketone (PEEK) is a new material used for the frameworks of removable partial dentures (RPD). The questions whether PEEK framework has similar stress distribution on oral tissue and displacement under masticatory forces as titanium alloy (Ti-6Al-4V) or cobalt-chromium (CoCr) remain unclear worth exploring. A patient’s intraoral data were obtained via CBCT master model scan. Four RPDs designed by 3Shape dental system, models processed three-dimensional finite element...
Ischemia-reperfusion (I/R) injury is detrimental to cardiovascular system. Alteration in glucose metabolism has been recognized as an important adaptive response under hypoxic conditions. However, the biological benefits underlying this metabolic phenotype remain be elucidated. This study was designed investigate impact of acclimation (HA) on cardiac I/R and antioxidative mechanism(s). Male adult mice were acclimated a chamber (10% oxygen [O2]) for 8 h/day 14 days, then subjected by ligation...
Abstract Objective To compare the accuracy of computer‐guided surgery and freehand on flapless immediate implant placement (IIP) in anterior maxilla. Material Methods In this split‐mouth design, 24 maxillary incisors eight human cadaver heads were randomly divided into two groups: ( n = 12) 12). Preoperatively, cone‐beam computed tomography (CBCT) scans acquired, all implants planned with a software (Blue Sky Plan3). Then, types surgeries performed. assess any differences position,...
Radiotherapy is a frequently used treatment for oral cancer. Extensive research has been conducted to detect the mechanical properties of dental hard tissues after irradiation at macroscale. However, little known about influence on tribological enamel micro- or nanoscale. Therefore, this study aimed investigate effect gamma wear behaviour human tooth in relation prism orientation. Nanoscratch tests, surface profilometer and scanning electron microscope (SEM) analysis were evaluate friction...
Abstract Endophilin A1 (EP) is a protein enriched in synaptic terminals that has been linked to Alzheimer’s disease (AD). Previous vitro studies have shown EP can bind variety of proteins, which elicit changes transmission neurotransmitters and spine formation. Additionally, we previously showed levels are elevated AD patients transgenic animal models. Here, establish the vivo consequences upregulation expression amyloid-β peptide (Aβ)-rich environments, leading both long-term potentiation...
The purpose of the study was to determine hardness and fracture toughness dental yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) manufactured by digital light processing (DLP) technology its clinical prospects.The experimental group DLP-manufactured zirconia, control milled zirconia. investigated under a range test loads (0.49 N, 0.98 1.96 4.90 9.81 29.42 49.03 98.07 196.1 N). Meyer's law applied describe indentation size effect (ISE). Meanwhile, PSR model MPSR were utilized...
Dental implants with long-term success of osseointegration have always been the goal, however, difficulties exist. The accumulation fretting damage at implant-bone interface often gets overlooked. Commonly used titanium is approximately 7-fold harder and stiffer than cortical bone. Stress shielding caused by mismatching elastic modulus aggravates interface, which accompanied risk formation proinflammatory metal debris implant loosening. Thus, authors explore functionalized bone-inspired...
The study determines the stability and durability of polyetheretherketone (PEEK) a carbon fiber-reinforced PEEK (CFR-PEEK) with 30% short fibers, dental composite based on Bis-GMA polymethylmethacrylate (PMMA) under influence different pH-values oral environment in vitro. Nanomechanical properties were investigated by nanoindentation nanoscratch tests before after incubation specimens at 37 °C for 30 days artificial saliva 3, 7 10, respectively. Nanoindentation nanoscratching performed using...
Loss of synapse and synaptic dysfunction contribute importantly to cognitive impairment in Alzheimer’s disease (AD). Mitochondrial oxidative stress are early pathological features AD-affected brain. However, the effect AD mitochondria on synaptogenesis remains be determined. Using human trans-mitochondrial “cybrid” (cytoplasmic hybrid) neuronal cells whose were transferred from platelets patients with sporadic or age-matched non-AD subjects relatively normal cognition, we provide first...
Although previous studies have implicated pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), to be detrimental for osteogenic activity, the related regulatory mechanisms are not yet fully validated. Since mitochondria host several essential metabolic processes play a pivotal role in cellular functions, whether how mitochondrial function contributes inflammation-induced bone destruction needs further exploration. Our findings revealed that TNF-α...
The virtual patient, a unique computer simulation of the patient's face, teeth, oral mucosa, and bone, provides an extraordinary mechanism for digital dental implant surgery planning prosthetic design. However, seamless registration scans with functional information in context articulator remains challenge. This report describes treatment 47-year-old male full-mouth guided immediate placement loading CAD/CAM interim prostheses. Utilizing novel workflow, multifactorial vertical dimension...
Abstract Objective This article describes a digital dental esthetic ceramic veneer treatment workflow using stereolithographic template for teeth preparation. Clinical Considerations We have presented the case of 33‐year‐old woman with fluorosis who wanted an treatment. A smile design was created on virtual patient, and diagnostic wax‐up made. Based suggested material thickness, preparation performed wax‐up. special‐teeth then digitally fabricated technique. guided special bur stopper. The...
Sirtuin 3 (SIRT3), a mitochondrial NAD+ -dependent deacetylase, has received much attention for its effect on metabolism and aging. However, the role of SIRT3 in periodontal disease remains unknown.This study aimed to investigate functional age-related underlying mechanisms.Sixteen mice were randomly assigned into four groups: young wild type (WT), aged WT, SIRT3-knockout (KO), SIRT3-KO. cyclophilin D (CypD) expression protein lysine acetylation levels alveolar bones detected by western...
Dysfunctional cholesterol metabolism is highly prevalent in patients with hyperuricemia. Both uric acid and are independent risk factors for atherosclerosis, contributing to an increased incidence of cardiovascular disease Investigating the pathological mechanisms underlying dysfunction hyperuricemia essential. This study identified adenosine inosine, two major purine metabolites, as key regulators biosynthesis. These metabolites up-regulate 3-hydroxy-3-methylglutaryl-CoA (HMGCR). Further...