A5038177652- Mitochondrial Function and Pathology
- Bone Metabolism and Diseases
- Alzheimer's disease research and treatments
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- ATP Synthase and ATPases Research
- Bone and Joint Diseases
- Advanced Glycation End Products research
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Dental materials and restorations
- Orthopedic Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- Metabolism and Genetic Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Adenosine and Purinergic Signaling
- Autophagy in Disease and Therapy
- Cholinesterase and Neurodegenerative Diseases
- Temporomandibular Joint Disorders
- Oral microbiology and periodontitis research
- MicroRNA in disease regulation
- MXene and MAX Phase Materials
Sichuan University
2016-2025
Liuzhou Maternal and Child Health Hospital
2025
State Key Laboratory of Oral Diseases
2015-2024
Stomatology Hospital
2016-2024
National Clinical Research
2022
University of Kansas
2013-2015
After an osteosarcoma resection, the risks of cancer recurrence, postoperative infection, and large bone loss still threaten patients' health. Conventional treatment relies on implanting orthopedic materials to fill defects after surgery, but it has no ability destroying residual tumor cells preventing bacterial invasion. To tackle this challenge, here, we develop a novel multifunctional implant (SP@MX/GelMA) that mainly consists MXene nanosheets, gelatin methacrylate (GelMA) hydrogels,...
Diabetes has adverse effects on the brain, especially hippocampus, which is particularly susceptible to synaptic injury and cognitive dysfunction. The underlying mechanisms strategies rescue such dysfunction are not well understood. Using a mouse model of type 2 diabetes (db/db mice) human neuronal cell line treated with high concentration glucose, we demonstrate aberrant mitochondrial morphology, reduced ATP production, impaired activity complex I. These abnormalities induced by imbalanced...
As a chronic metabolic disease, diabetes mellitus (DM) creates hyperglycemic micromilieu around implants, resulting inthe high complication and failure rate of implantation because mitochondrial dysfunction in hyperglycemia. To address the daunting issue, authors innovatively devised developed mitochondria-targeted orthopedic implants consisted nutrient element coatings polyetheretherketone (PEEK). Dual elements, modality ZnO Sr(OH)2 , are assembled onto sulfonated PEEK surface...
Abstract Phototherapy has recently emerged as a competent alternative for combating bacterial infection without antibiotic‐resistance risk. However, owing to the endogenous antioxidative glutathione (GSH), exogenous reactive oxygen species (ROS) generated by phototherapy can hardly behave desired antibacterial effect. To address daunting issue, quad‐channel synergistic nano‐platform of Ti 3 C 2 MXene/MoS (MM) 2D bio‐heterojunctions (2D bio‐HJs) are devised and fabricated, which possess...
Sustained release of bioactive BMP2 (bone morphogenetic protein-2) is important for bone regeneration, while the intrinsic short half-life at protein level cannot meet clinical need. In this study, we aimed to design Bmp2 mRNA-enriched engineered exosomes, which were then loaded into specific hydrogel achieve sustained more efficient and safe regeneration.Bmp2 mRNA was enriched exosomes by selective inhibition translation in donor cells, NoBody (non-annotated P-body dissociating polypeptide,...
A new GelMA/κ-carrageenan (GelMA/KC) double network (DN) hydrogel with excellent physical properties and biocompatibility is developed through a cross-linking strategy.
Orthopedic and dental implantations under bacterial infection microenvironment face significant challenges in achieving high-quality bone-implant integration. Designing implant coatings that incorporate both immune defense anti-inflammation is difficult conventional single-functional coatings. We introduce a multifunctional nanointerface using zinc finger-inspired peptide-metal-phenolic nanocoating, designed to enhance osseointegration such conditions. Abaloparatide (ABL), second-generation...
Oxygen deficiency is associated with various oral diseases, including chronic periodontitis, age-related alveolar bone loss, and mechanical stress-linked cell injury from orthodontic appliances. Nevertheless, our understanding of the impact hypoxia on periodontal tissues its biochemical mechanism still rudimentary. The purpose this research was to elucidate effects apoptosis human ligament stem cells (PDLSCs) in vitro underlying mechanism. Herein, we showed that cobalt chloride (CoCl2)...
Diabetes mellitus is a well-recognized risk factor for periodontitis. The goal of the present study was to elucidate whether oxidative stress and nuclear erythroid 2-related 2 (Nrf2) participate in aggravation periodontitis by diabetes. For this purpose, we assigned Wistar rats control, periodontitis, diabetes, diabetic groups. Two weeks after induction diabetes streptozotocin, induced ligation. later, periodontal tissues blood were harvested analyzed stereomicroscopy, immunohistochemistry,...
Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting ABAD may represent novel therapeutic strategy against AD. Here, we report the biological activity of small molecule inhibitors. Using vitro surface plasmon resonance (SPR) studies, synthesized compounds with strong affinities ABAD. Further, these inhibitors (ABAD-4a...
Intracerebral hemorrhage (ICH) is a serious public health problem with high rates of death and disability. The neuroprotective effect Growth Differentiation Factor 11 (GDF11) in ICH has been initially proved by our previous study. Oxidative stress (OS) plays crucial roles mediating subsequent damage ICH. However, whether how mitochondrial dynamic events function participated pathophysiology, OS interreacted the process GDF11 remains unclarified. Based on rat model vitro cell model, we...
Although previous studies have implicated pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), to be detrimental for osteogenic activity, the related regulatory mechanisms are not yet fully validated. Since mitochondria host several essential metabolic processes play a pivotal role in cellular functions, whether how mitochondrial function contributes inflammation-induced bone destruction needs further exploration. Our findings revealed that TNF-α...
Sirtuin 3 (SIRT3), a mitochondrial NAD+ -dependent deacetylase, has received much attention for its effect on metabolism and aging. However, the role of SIRT3 in periodontal disease remains unknown.This study aimed to investigate functional age-related underlying mechanisms.Sixteen mice were randomly assigned into four groups: young wild type (WT), aged WT, SIRT3-knockout (KO), SIRT3-KO. cyclophilin D (CypD) expression protein lysine acetylation levels alveolar bones detected by western...
This case report describes orthodontic treatment of an adult female with severe skeletal Class II malocclusion on a base complicated by deficient chin, condylar resorption and anterior open bite (The IOFTN score = 4.4, ANB °=11.3, SN-MP °=58.2). Treatment carried out 4 1st premolar extractions using two mini-implants (diameter: 1.6 mm; length: 10 Cibei Medical Instruments, Ningbo, China) that were inserted between the maxillary first molar second to intrude bilateral molars elastic traction....