A5100451063- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Spine and Intervertebral Disc Pathology
- Intensive Care Unit Cognitive Disorders
- Alzheimer's disease research and treatments
- Hydrogen's biological and therapeutic effects
- Neuropeptides and Animal Physiology
- Spaceflight effects on biology
- Nerve injury and regeneration
- Ion channel regulation and function
- Pediatric Pain Management Techniques
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare and Venom Research
- Cancer, Stress, Anesthesia, and Immune Response
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Epigenetics and DNA Methylation
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Neuropathies and Disorders
- Pharmacological Receptor Mechanisms and Effects
- Pain Management and Opioid Use
Tianjin Medical University General Hospital
2016-2025
Hebei Medical University
2025
Fourth Hospital of Hebei Medical University
2025
China Astronaut Research and Training Center
2006-2024
China Medical University
2011-2022
SingHealth Polyclinics
2022
Tianjin Hospital
2019-2020
Women's Hospital, School of Medicine, Zhejiang University
2020
Chelsea and Westminster Hospital
2018
Novem (Netherlands)
2018
Spinal cord injury (SCI) can cause permanent loss of sensory and motor function, there is no effective clinical treatment, to date. Due the complex pathological process involved after injury, synergistic treatments are very urgently needed in practice. We designed a nanofiber scaffold hyaluronic acid hydrogel patch release both exosomes methylprednisolone injured spinal non-invasive manner. This composite showed good biocompatibility stabilization exosome morphology toxicity nerve cells....
During spaceflight, the cardiovascular system undergoes remarkable adaptation to microgravity and faces risk of cardiac remodeling. Therefore, effects mechanisms on morphology, physiology, metabolism, cellular biology need be further investigated. Since China started constructing Space Station (CSS) in 2021, we have taken advantage Shenzhou-13 capsule send human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) Tianhe core module CSS. In this study, hPSC-CMs subjected space showed...
Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Several factors within the perioperative period may influence postoperative metastatic spread. Dexmedetomidine and midazolam are widely used general anesthetics during surgery. The authors assessed their effects on human lung carcinoma (A549) neuroglioma (H4) cell lines in vitro vivo. Methods Cell proliferation migration were measured after dexmedetomidine (0.001 to 10 nM) or (0.01 400...
Aims: There is mounting evidence that the transition metal copper may play an important role in pathophysiology of Alzheimer's disease (AD). Triethylene tetramine dihydrochloride (trientine), a CuII-selective chelator, commonly used treatment for Wilson's to decrease accumulated copper, and thereby decreases oxidative stress. In present study, we evaluated effects 3-month course trientine (Trien) on amyloidosis 7-month-old β-amyloid (Aβ) precursor protein presenilin-1 (APP/PS1) double...
Alzheimer's disease (AD) is an age-related neurological disorder. Currently, there no effective cure for AD due to its complexity in pathogenesis. In light of the complex pathogenesis AD, traditional Chinese medicine (TCM) formula Kai-Xin-San (KXS), which was used amnesia treatment, has been proved improve cognitive function animal models. However, active ingredients and mechanism KXS have not yet clearly elucidated. this study, network pharmacology analysis predicts that yields 168...
Remimazolam tosilate (RT) is a new short-acting γ-aminobutyric acid A (GABAA) receptors agonist. However, its optimal use mode and dosage still remain unclear. This study aimed to examine the safety effectiveness of combination RT propofol in gastroscopy. was prospective, single-blind, randomized, multicenter, parallel-group study. All eligible 256 patients were randomized into following 3 groups. Patients anesthetized with (Group P), R) or RP). The primary efficacy endpoints were: body...
Metal dyshomeostasis in the brain helps promote amyloid-β (Aβ) deposition Alzheimer's disease (AD). Therefore, targeting interactions between metal and Aβ is a potential therapeutic approach for AD. The chelator, clioquinol (CQ), thou
Alzheimer's disease (AD) is histopathologically characterized by the build-up of fibrillar amyloid beta (Aβ) in form plaques and development intraneuronal neurofibrillary tangles consisting aggregated hyperphosphorylated Tau. Although fibrils were originally considered responsible for AD pathogenesis, recent convincing evidence strongly implicates soluble oligomeric Aβ as primary neurotoxic species driving progression. A third largely ignored pathological hallmark, described Alois Alzheimer,...
Diabetic neuropathy is a major complication of diabetes. Current treatment options alleviate pain but do not stop the progression disease. At present, there are no approved disease-modifying therapies. Thus, developing more effective therapies remains unmet medical need. Seeking to better understand molecular mechanisms driving peripheral neuropathy, as well other neurological complications associated with diabetes, we performed spatiotemporal lipidomics, biochemical, ultrastructural, and...
Hyperalgesia is one of the negative consequences following intraoperative analgesia with remifentanil. Peroxynitrite a critical determinant in nociceptive process. inactivates iron-sulfur cluster that results mitochondrial dysfunction and release iron, leading to iron accumulation. Iron accumulation mediated by divalent metal transporter 1 (DMT1) plays key role N-methyl-D-aspartate neurotoxicity. This study aims determine whether peroxynitrite contributes remifentanil-induced postoperative...
A large number of experimental and clinical studies have confirmed that brief remifentanil exposure can enhance pain sensitivity presenting as opioid-induced hyperalgesia (OIH). N-methyl-D-aspartate (NMDA) receptor antagonists been reported to inhibit morphine analgesic tolerance in many studies. Recently, we found glycogen synthase kinase-3β (GSK-3β) modulated NMDA trafficking a rat model remifentanil-induced postoperative hyperalgesia. In the current study, it was demonstrated GSK-3β...
Intraoperative remifentanil anesthesia exaggerates postoperative pain sensitivity. Recent studies recapitulate the significance of protein kinase Mζ in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated pathologic pain. Kalirin-7, a Rho guanine nucleotide exchange factor, coordinates AMPA receptor trafficking and dendritic spine plasticity. This study examines whether Kalirin-7 contribute to remifentanil-induced postincisional hyperalgesia via receptor.Plantar...
Abstract Chronic postoperative pain hinders functional recovery after bone fracture and orthopedic surgery. Recently reported evidence indicates that caspase-6 is important in excitatory synaptic plasticity pathological pain. Meanwhile, netrin-1 controls postsynaptic recruitment of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) synaptogenesis. The present work aimed to examine whether contribute fracture-induced allodynia. A mouse model tibial by intramedullary pinning...
The study investigates the effectiveness of immersive virtual reality (VR) as a nonpharmaceutical approach to manage postoperative pain in patients following thoracoscopic surgery. In this single-center, triple-arm pilot randomized controlled trial (RCT), 61 postsurgical with numerical rating scale (NRS) score ≥4 after receiving standard analgesia were included and assigned either quantum clinics-VR (QTC-VR) group, Placebo-VR or control group. QTC-VR group engaged daily 10-minute interactive...
Reactive cutaneous capillary endothelial proliferation (RCCEP) is a common immune-related adverse event (irAE) related to camrelizumab. This study sought investigate the relationship between RCCEP and treatment efficacy of camrelizumab in esophageal cancer (EC), explore risk factors for RCCEP. retrospective collected data patients with EC who were treated November 2019 2023. The divided into RCCEP-negative groups RCCEP-positive based on occurrence Subsequently, Chi-squared test was applied...
Multidrug resistance (MDR) is a major cause for incurable breast cancer. Salvianolic acid A (SAA), the hydrophilic polyphenolic derivative of Salvia miltiorrhiza Bunge (Danshen/Red Sage), was examined cytotoxicities to MDR MCF-7 human cancer cells and their parental counterparts. We have shown that SAA inhibited proliferation, caused cell cycle arrest at S phase, induced apoptosis dose dependently two kinds cells. However, resistant were significantly susceptible inhibition compared with...