A5034643467- Multiple Myeloma Research and Treatments
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Protein Degradation and Inhibitors
- Algal biology and biofuel production
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Advancements in Transdermal Drug Delivery
- Nanoplatforms for cancer theranostics
- Lymphoma Diagnosis and Treatment
- Advanced Battery Technologies Research
- Long-Term Effects of COVID-19
- PI3K/AKT/mTOR signaling in cancer
- Genomics and Phylogenetic Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Cell Adhesion Molecules Research
Fujian Medical University
2016-2025
First Affiliated Hospital of Fujian Medical University
2016-2025
Jiangnan University
2023-2025
Shenzhen University
2016-2024
Guizhou University
2007-2024
Sun Yat-sen University
2007-2024
Yangzhou University
2022-2024
China University of Mining and Technology
2024
Zhejiang Sci-Tech University
2020-2023
Jiangxi University of Science and Technology
2023
Abstract Background The enhancer of zeste homolog 2 (EZH2) was found to be overexpressed and associated with tumor metastasis in esophageal squamous cell carcinoma (ESCC). On the other hand, it reported that miR-26a, miR-98, miR-101, miR-124, miR-138 miR-214 could inhibit expression EZH2 some tumors. However, role miRNAs regulation human ESCC has not been documented. aim this study determine these via overexpression ESCC. Methods results mRNA were examined by qPCR protein detected western...
Abstract Background Early identification of patients who are at high risk poor clinical outcomes is great importance in saving the lives with novel coronavirus disease 2019 (COVID-19) context limited medical resources. Objective To evaluate value neutrophil to lymphocyte ratio (NLR), calculated hospital admission and isolation, for prediction subsequent presence progression serious (e.g., shock, death). Methods We designed a prospective cohort study 352 hospitalized COVID-19 between January...
Skin ulcers are one of the complications diabetes. At present, treatment diabetic skin wounds is still not satisfactory, and efficiency drug delivery limited by depth penetration. Herein, a synergistically flexible microneedle dressing presented for effectively promoting wound healing. Metformin, as an anti-diabetic drug, can be loaded into microneedles, which pierce rats to trigger response regulating blood glucose levels. A novel multifunctional nanosystem CaO2@polydopamine (CaO2@PDA) was...
Defect engineering was used to address the poor electronic conductivity of NaTi 2 (PO 4 ) 3 . Sufficient V O promotes localization Ti1, Ti2, and P1 cations, while delocalizes atoms, which boosts Na storage efficiency rapid diffusion kinetics.
Abstract Background This study was performed to investigate the effect of microRNA-203 (miR-203) and ΔNp63 on cell proliferation functional connection between miR-203 in ESCC. Methods We employed 2 human ESCC lines, Eca109 TE-1, as model system. The determined cells transfected with mimic small interfering RNA (siRNA), respectively. regulation expression by studied luciferase reporter assay, RT-PCR western blot analysis miR-203. re-expression induced inhibition assay cotransfected...
It is extremely important to develop a minimally invasive and efficient approach for treatment of superficial skin tumors (SSTs). In this work, near-infrared (NIR)-triggered transdermal therapeutic system based on two-stage separable microneedles (MNs) has been proposed synergistic chemo-photothermal therapy against SSTs. Lauric acid polycaprolactone as phase-change materials have used prepare the arrowheads MNs in which an anticancer drug (doxorubicin, DOX) photothermal agent (indocyanine...
Previous study showed that mitochondrial ND6 (mitND6) gene missense mutation resulted in NADH dehydrogenase deficiency and was associated with tumor metastasis several mouse cell lines. In the present study, we investigated possible role of mitND6 nonsense mutations human lung adenocarcinoma.The presence screened by DNA sequencing tissues from 87 primary adenocarcinoma patients correlation clinical features analyzed. addition, constructed cytoplasmic hybrid cells denucleared as mitochondria...
Abstract Microalgae are regarded as the most promising biofuel candidates and extensive metabolic engineering were conducted but very few improvements achieved. Long non-coding RNA (lncRNA) investigation manipulation may provide new insights for this issue. LncRNAs refer to transcripts that longer than 200 nucleotides, do not encode proteins play important roles in eukaryotic gene regulation. However, no information of potential lncRNAs has been reported alga. Recently, we performed...
The development of multifunctional nanoformulations (NFs) include several features in a single nanosystem for these devices to overcome the disadvantages inefficiency and undesirable toxicity traditional therapies provide new opportunities management tumors. Herein, CaO2@Mn-PDA NFs with core-shell structure, integrating photothermal conversion properties Mn-PDA, chemodynamic doped Mn ions, relieving hypoxia tumor microenvironment (TME) were developed. as-fabricated embedded microneedles...
Chlamydomonas reinhardtii is an ideal model organism not only for the study of basic metabolic processes in both plants and animals but also production biofuels including hydrogen. Transgenic analysis C. now well established very convenient, inducible exogenous gene expression systems remain under-studied. The most commonly used heat shock-inducible system has serious effects on algal cell growth difficult costly to control large-scale culture. Previous studies hydrogen photoproduction use...
Summary Our previous study revealed that Yin Yang 1(YY1) played an important part in promoting interleukin (IL)-6 production rheumatoid arthritis (RA). However, whether YY1 has any role regulation of IL-8 RA remains unclear. and expression patients were analyzed by real-time polymerase chain reaction (PCR). Ingenuity pathway analysis (IPA) was used to analyze the signaling involved YY1-induced production. The proteins detected Western blot enzyme-linked immunosorbent assay (ELISA). Migration...
Traditional electric vehicle (EV) battery drive trains comprise hard-wired batteries forming a fixed high-voltage DC link, and main inverter. This paper proposes novel topology to break into smaller subunits interfaced by low-voltage field effect transistors (FET). The new named <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reconfigurable battery</i> , can offload great portion of the switching duty from Several benefits follow:...