A5046614193- Advancements in Transdermal Drug Delivery
- Wound Healing and Treatments
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Dermatology and Skin Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Polymer Surface Interaction Studies
- Hydrogels: synthesis, properties, applications
- Bee Products Chemical Analysis
- Extracellular vesicles in disease
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- biodegradable polymer synthesis and properties
- Thallium and Germanium Studies
- Optical Coherence Tomography Applications
- Carbon and Quantum Dots Applications
- Surgical Sutures and Adhesives
- Advanced biosensing and bioanalysis techniques
- Hemostasis and retained surgical items
- Ocular Oncology and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Molecular Communication and Nanonetworks
- Oral and gingival health research
Belarusian State University
2021-2025
Skin ulcers are one of the complications diabetes. At present, treatment diabetic skin wounds is still not satisfactory, and efficiency drug delivery limited by depth penetration. Herein, a synergistically flexible microneedle dressing presented for effectively promoting wound healing. Metformin, as an anti-diabetic drug, can be loaded into microneedles, which pierce rats to trigger response regulating blood glucose levels. A novel multifunctional nanosystem CaO2@polydopamine (CaO2@PDA) was...
Skin regeneration of full-thickness wounds remains a challenge, requiring well-regulated interplay cell–cell and cell–matrix signaling. Herein, the composite hydrogel films composed silk fibroin (SF) polyvinyl alcohol (PVA) as scaffolds loaded with curcumin nanoparticles (Cur NPs) were developed for skin wound healing. The structure physicochemical properties first evaluated by scanning electron microscopy (SEM), water contact angle, chemical mechanical measurements. In addition,...
Abstract The conventional therapeutic treatment of triple‐negative breast cancer (TNBC) is negatively influenced by the development tumor cell drug resistant, and systemic toxicity agents due to off‐target activity. In accordance with research findings, nanoparticles (NPs) responsive microenvironment (TME) have been discovered for providing opportunities selectively target cells via active targeting or Enhanced Permeability Retention (EPR) effect. combination TME control NPs offers promising...
Allopurinol (AP) is widely used to treat hyperuricemia which may cause severe side effects upon oral administration. Alternative means for the treatment of are demanded simultaneously facilitate drug absorption, patient compliance, and fewer effects. In this study, a new polymer microneedle (MN) system was developed transdermal delivery AP acute hyperuricemic mice. This study aims achieve controllable regulation serum uric acid (SUA) levels with compared The matrix MNs consisted...
Nanobiotechnology is an actively developing field of science, which finds application in cancer therapy, molecular diagnostics and imaging. In this work, selenium nanoparticles were successfully obtained by chemical reduction selenite ions with ascorbic acid dextran phosphate (DP) solutions, was used as a stabilizer. It has been found that coated are stable during storage for 3 days. Sorption the antitumor substance doxorubicin studied concentration range from 0.1 mg/ml to 1 mg/ml. A...
Combinations of different therapeutic strategies, including chemotherapy (CT), chemodynamic therapy (CDT), and photothermal (PTT), are needed to effectively address evolving drug resistance the adverse effects traditional cancer treatment. Herein, a camouflage composite nanoformulation (TCBG@PR), an antitumor agent (tubercidin, Tub) loaded into Cu-doped bioactive glasses (CBGs) subsequently camouflaged by polydopamine (PDA), red blood cell membranes (RBCm), was successfully constructed for...
Breast cancer (BC) is the most frequently diagnosed in women worldwide. Chemodynamic therapy (CDT), photothermal (PTT), and ion interference (IIT), used combination, represent a common treatment. In this study, platelet membrane-camouflaged copper-doped CaO2 biomimetic nanomedicines have been developed for breast treatments. Copper-doped nanoparticles were first coated by polydopamine (PDA) subsequently camouflaged membrane (PM) to form copper doped (Cu-CaO2@PDA/PM). The as-fabricated...
Diabetes chronic wound is a serve and frequently occurring medical issues in patients with diabetes that often lead to more serious complications. Microneedle (MN）patches can be used for healing since they are able efficiently pierce the epidermis deliver drugs into tissue. However, regular MN patches cannot provide adequate skin adhesion prevent them from shedding on area. Herein, inspired by natural hangnail microstructure of porcupine quills, we designed quill-like multilayer patch an...
Electrospun fibrous scaffolds for tissue engineering have been widely used due to their effective simulation of extracellular matrix (ECM). However, traditional two-dimensional (2D) electrospun limited application in compact structure and small pore sizes. In this work, the novel three-dimensional (3D) polycaprolactone/ε-polylysine modified chitosan (PCL/PCS) were developed following an electrospinning gas foaming technique. The 3D PCL/PCS fiber higher porosity interlaminar gaps than those...