A5100721349- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Macrophage Migration Inhibitory Factor
- IL-33, ST2, and ILC Pathways
- Extracellular vesicles in disease
- Inflammasome and immune disorders
- Mesenchymal stem cell research
- Galectins and Cancer Biology
- Immune cells in cancer
- Hydrogen's biological and therapeutic effects
- Organ and Tissue Transplantation Research
- Ferroptosis and cancer prognosis
- Wound Healing and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Transplantation: Methods and Outcomes
- Inflammatory Bowel Disease
- Nerve injury and regeneration
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Gynecological conditions and treatments
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Issues in Pregnancy
Tianjin Medical University General Hospital
2020-2024
Tianjin Medical University
2020-2024
Second Hospital of Tianjin Medical University
2020
Weatherford College
2020
Abstract Macrophage/microglia polarization acts as an important part in regulating inflammatory responses spinal cord injury (SCI). However, the regulation of inflammation Schwann cell-derived exosomes (SCDEs) for SCI repair is still unclear. Therefore, we intend to find out effect SCDEs on related macrophage during recovery SCI. Firstly, thesis demonstrated that could attenuate LPS- BMDMs by suppressing M1 and stimulating M2 polarization. Similarly, improved functional female Wistar rats...
Inflammatory response is an essential part of secondary injury after spinal cord (SCI). During this period, the may be exacerbated through release a large number inflammatory factors and polarization infiltrating macrophages microglia towards M1. Ang-(1-7), mainly generated by Ang II via angiotensin-converting enzyme 2 (ACE2), can specifically bind to G protein-coupled receptor Mas (MasR) plays important role in regulating inflammation alleviating oxidative stress. We aimed investigate...
JOURNAL/nrgr/04.03/01300535-202404000-00036/inline-graphic1/v/2023-09-09T133047Z/r/image-tiff Complete transverse injury of peripheral nerves is challenging to treat. Exosomes secreted by human umbilical cord mesenchymal stem cells are considered play an important role in intercellular communication and regulate tissue regeneration. In previous studies, a collagen/hyaluronic acid sponge was shown provide suitable regeneration environment for Schwann cell proliferation promote axonal This...
Endometrial regenerative cells (ERCs) have been identified to ameliorate colitis in mice; however, whether exosomes derived from ERCs (ERC-exos) own similar effects on remains unclear. Ferroptosis, an iron-dependent cell programmed death form, has reported promote inflammation UC. Thus, this study, ERC-exos can treat and regulate intestine ferroptosis will be explored. In iron, malondialdehyde (MDA) production, glutathione (GSH) synthesis, acyl-CoA synthetase long-chain family member (ACSL)...
Abstract Panax notoginseng is a widely used herb in traditional Chinese medicine renowned for its unique dual functionality promoting blood circulation and stopping bleeding. However, the specific active components molecular mechanisms underlying seemingly contradictory effects of P. remain unclear. This article reviews literature on focusing use conditions including cardiovascular diseases, circulation, hemostasis. It provides panoramic view regulatory roles different maintaining vascular...
Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cells, were identified as an attractive candidate for immunoregulation and induction cardiac allograft tolerance. However, the underlying mechanisms ERCs in immune regulation still remain largely unclear. The present study is designed to determine whether expression Galectin-9 (Gal-9), soluble tandem-repeat member galectin family, crucial ERC-based immunomodulation.In this study, we measured Gal-9 on then...
Endotoxemia remains a major cause of mortality in the intensive care unit, but therapeutic strategy is still lacking. Mesenchymal stem cell (MSC) was reported with tissue-oriented differentiation ability and an excellent immunoregulatory capacity. However, immunity signaling pathways that govern MSC modulation effect are not completely understood. In our current study, MSCs (2.5 × 10 5 /ml) were obtained stimulated IFN-γ (20 ng/ml) for 72 h. Gal-9 expression on measured by ELISA, RT-PCR,...
Ischemia reperfusion injury (IRI) is the major cause of intestinal damage in clinic. Although either mesenchymal stromal cells (MSCs) or interleukin 37 (IL-37) shows some beneficial roles to ameliorate IRI, their effects are limited. In this study, preventative IL-37 gene-modified MSCs (IL-37-MSCs) on IRI investigated. Intestinal model was established by occluding superior mesenteric artery for 30 minutes and then reperfused 72 hours rats. Forty adult male Sprague-Dawley rats were randomly...
Abstract Background Ulcerative colitis (UC) is a chronic, relapsing, and non-specific inflammatory bowel disease, the current treatment strategies were mainly used to relieve symptoms or for maintenance. Endometrial regenerative cells (ERCs) are mesenchymal-like stromal have been demonstrated alleviate multiple immune-dysregulation diseases. Pro-inflammatory stimuli reported enhance immunosuppressive functions of ERCs, but mechanism underlined not fully understood. Here, we designed this...
Traditional interventions can play a certain role in attenuating ulcerative colitis (UC), known as one type of inflammatory bowel diseases, but sometimes are not effective. Endometrial regenerative cells (ERCs) have been shown to exert immunosuppressive effects different models inflammation, and stem cell-derived conditioned media (CM) advantages over cell therapy terms easy access direct action. However, whether ERC-CM could alleviate remains unclear will be explored this study. Menstrual...
Abstract Background Autoimmune hepatitis (AIH) is a T cell-mediated immune disease that activates abnormally against hepatic antigens. We have previously reported endometrial regenerative cells (ERCs) were novel source of adult stem cells, which exhibiting with powerful immunomodulatory effects. Galectin-9 (Gal-9) expressed in ERCs and plays an important role regulating cell response. This study aims to explore the attenuation AIH determine potential mechanism Gal-9 ERC-mediated regulation....
The prognostic value of m6A-related genes in hepatocellular carcinoma (HCC) and its correlation with the immune microenvironment still requires further investigation.Consensus clustering by m6A related was used to classify 374 patients HCC from Cancer Genome Atlas (TCGA) database. Then we performed least absolute shrinkage selection operator (LASSO) construct model. International Consortium (ICGC) Gene Expression Omnibus (GEO) datasets were verify evaluate ESTIMATE, CIBERSORTx, expression...
Abstract Background Endometrial regenerative cells (ERCs) play an important role in attenuation of acute allograft rejection, while their effects are limited. IL-37, a newly discovered immunoregulatory cytokine the IL-1 family, can regulate both innate and adaptive immunity. Whether IL-37 overexpression enhance therapeutic ERCs inhibition cardiac rejection remains unknown will be explored this study. Methods C57BL/6 mice recipients receiving BALB/c mouse heterotopic heart allografts were...
Abstract Background As a kind of mesenchymal-like stromal cells, endometrial regenerative cells (ERCs) have been demonstrated effective in the treatment Concanavalin A (Con A)-induced hepatitis. However, therapeutic mechanism ERCs is not fully understood. Ecto-5`-nucleotidase (CD73), an enzyme that could convert immune-stimulative adenosine monophosphate (AMP) to immune-suppressive (ADO), was identified highly expressed on ERCs. The present study conducted investigate whether expression CD73...
Abstract Background : Ischemia reperfusion injury (IRI) is the major cause of intestinal damage in clinic. Although either mesenchymal stromal cells (MSCs) or interleukin 37 (IL-37) showed some beneficial roles to ameliorate IRI, their effects are limited. In this study, protective IL-37 gene-modified MSCs (IL-37-MSCs) for better prevention IRI investigated. Methods Intestinal model was established by occluding superior mesenteric artery 30min and then reperfusing 72 hours rats. Forty adult...
Ulcerative colitis (UC) is a chronic intestinal inflammatory disease with complex etiology. Interleukin-35 (IL-35), as cytokine immunomodulatory function, has been shown to have therapeutic effects on UC, but its mechanism not yet clear. Therefore, we constructed Pichia pastoris stably expressing IL-35 which enables the cytokines reach diseased mucosa, and explored whether upregulation of T-cell protein tyrosine phosphatase (TCPTP) in macrophages involved mechanisms IL-35-mediated...
Immunotherapy has been considered as a promising cancer treatment for hepatocellular carcinoma (HCC). However, due to the particular immune environment of liver, identifying patients who could benefit from immunotherapy is critical in clinical practice.The pyroptosis gene expression database 54 candidates The Cancer Genome Atlas (TCGA) were collected discover prognostic-related genes. A novel model was established calculate risk score. Kaplan-Meier analysis and receiver operating...