A5103175701- Microbial Natural Products and Biosynthesis
- Acupuncture Treatment Research Studies
- Collaboration in agile enterprises
- Complementary and Alternative Medicine Studies
- Innovative Educational Techniques
- Chemical Synthesis and Analysis
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
- Plant biochemistry and biosynthesis
- Infant Nutrition and Health
- Computational Drug Discovery Methods
- Diabetes and associated disorders
- Wireless Sensor Networks and IoT
- Marine Sponges and Natural Products
- Immune cells in cancer
Tianjin Medical University General Hospital
2023
Huazhong Agricultural University
2006-2018
Zhejiang University
2018
Inflammatory response is an essential part of secondary injury after spinal cord (SCI). During this period, the may be exacerbated through release a large number inflammatory factors and polarization infiltrating macrophages microglia towards M1. Ang-(1-7), mainly generated by Ang II via angiotensin-converting enzyme 2 (ACE2), can specifically bind to G protein-coupled receptor Mas (MasR) plays important role in regulating inflammation alleviating oxidative stress. We aimed investigate...
This is a new golden age for drug discovery based on natural products derived from both marine and terrestrial sources. Herein, straightforward but important question "what are the major structural differences between (MNPs) (TNPs)?" To answer this question, we analyzed physicochemical properties, features, drug-likeness of two types discussed their perspective evolution. In general, MNPs have lower solubility often larger than TNPs. On average, particularly unique fragments scaffolds,...
Large purchasable screening libraries of small molecules afforded by commercial vendors are indispensable sources for virtual (VS). Selecting an optimal library a specific VS campaign is quite important to improve the success rates and avoid wasting resources in later experimental phases. Analysis structural features molecular diversity different can provide valuable information decision making process when selecting VS. In this study, scaffold eleven Traditional Chinese Medicine Compound...