A5072585003- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Endometriosis Research and Treatment
- Transplantation: Methods and Outcomes
- Macrophage Migration Inhibitory Factor
- Organ Transplantation Techniques and Outcomes
- Psoriasis: Treatment and Pathogenesis
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Renal Transplantation Outcomes and Treatments
- Advanced Nanomaterials in Catalysis
- Adenosine and Purinergic Signaling
- Pregnancy and Medication Impact
- Neuropeptides and Animal Physiology
- Cancer Immunotherapy and Biomarkers
- Circadian rhythm and melatonin
- Dermatology and Skin Diseases
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Organ and Tissue Transplantation Research
- RNA modifications and cancer
Tianjin Medical University General Hospital
2021-2024
Jinhua Central Hospital
2024
Wenzhou Medical University
2024
Tianjin Medical University
2021-2024
Endometrial regenerative cells (ERCs) have been identified to ameliorate colitis in mice; however, whether exosomes derived from ERCs (ERC-exos) own similar effects on remains unclear. Ferroptosis, an iron-dependent cell programmed death form, has reported promote inflammation UC. Thus, this study, ERC-exos can treat and regulate intestine ferroptosis will be explored. In iron, malondialdehyde (MDA) production, glutathione (GSH) synthesis, acyl-CoA synthetase long-chain family member (ACSL)...
Solid organ transplantation remains a life-saving therapeutic option for patients with end-stage dysfunction. Acute cellular rejection (ACR), dominated by dendritic cells (DCs) and CD4
Abstract The majority of patients with advanced colorectal cancer have chemoresistance to oxaliplatin, and studies on oxaliplatin resistance are limited. Our research showed that RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) caused ferroptosis in tumor cells, leading resistance. We employed bioinformatics evaluate publically accessible data sets discovered RBMS1 was significantly upregulated oxaliplatin‐resistant tandem suppression. In vivo vitro revealed inhibiting...
Traditional interventions can play a certain role in attenuating ulcerative colitis (UC), known as one type of inflammatory bowel diseases, but sometimes are not effective. Endometrial regenerative cells (ERCs) have been shown to exert immunosuppressive effects different models inflammation, and stem cell-derived conditioned media (CM) advantages over cell therapy terms easy access direct action. However, whether ERC-CM could alleviate remains unclear will be explored this study. Menstrual...
Abstract Background Endometrial regenerative cells (ERCs) play an important role in attenuation of acute allograft rejection, while their effects are limited. IL-37, a newly discovered immunoregulatory cytokine the IL-1 family, can regulate both innate and adaptive immunity. Whether IL-37 overexpression enhance therapeutic ERCs inhibition cardiac rejection remains unknown will be explored this study. Methods C57BL/6 mice recipients receiving BALB/c mouse heterotopic heart allografts were...
The disruption of intestinal barrier functions and the dysregulation mucosal immune responses, mediated by aberrant purinergic metabolism, are involved in pathogenesis inflammatory bowel diseases (IBD). A novel mesenchymal-like endometrial regenerative cells (ERCs) has demonstrated a significant therapeutic effect on colitis. As phenotypic marker ERCs, CD73 been largely neglected for its immunosuppressive function regulating metabolism. Here, we have investigated whether expression ERCs is...
Abstract Background As a kind of mesenchymal-like stromal cells, endometrial regenerative cells (ERCs) have been demonstrated effective in the treatment Concanavalin A (Con A)-induced hepatitis. However, therapeutic mechanism ERCs is not fully understood. Ecto-5`-nucleotidase (CD73), an enzyme that could convert immune-stimulative adenosine monophosphate (AMP) to immune-suppressive (ADO), was identified highly expressed on ERCs. The present study conducted investigate whether expression CD73...
Background Chronic rejection characterized by chronic allograft vasculopathy (CAV) remains a major obstacle to long-term graft survival. Due multiple complicated mechanisms involved, novel therapy for CAV exploration. Although mesenchymal stromal cells (MSCs) have been ubiquitously applied various refractory immune-related diseases, rare research makes thorough inquiry in CAV. Meanwhile, melatonin (MT), wide spectrum of immunomodulator, plays non-negligible role transplantation immunity....