A5100726255- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Lipid metabolism and biosynthesis
- RNA Interference and Gene Delivery
- TGF-β signaling in diseases
- Nitrogen and Sulfur Effects on Brassica
- Nuclear Receptors and Signaling
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Hematopoietic Stem Cell Transplantation
- Plant Gene Expression Analysis
- Ferroptosis and cancer prognosis
- Lipid metabolism and disorders
- Cancer Immunotherapy and Biomarkers
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biotin and Related Studies
- Transplantation: Methods and Outcomes
- Inflammasome and immune disorders
- Connective Tissue Growth Factor Research
- Nerve injury and regeneration
Second Affiliated Hospital of Nanjing Medical University
2024
Hybrid Rapeseed Research Center of Shaanxi Province
2013-2023
Nanjing Medical University
2015-2022
Jiangsu Province Hospital
2017-2022
Guangxi Medical University
2021
Tianjin Medical University General Hospital
2021
Southern University of Science and Technology
2021
Capital Medical University
2008-2019
Beijing Tian Tan Hospital
2018-2019
Wake Forest University
2018
Increasing seed oil content is one of the most important goals in breeding rapeseed (B. napus L.). To dissect genetic basis B. napus, a large and new double haploid (DH) population containing 348 lines was obtained from cross between 'KenC-8' 'N53-2', two varieties with >10% difference content, this named KN DH population. A linkage map consisting 403 markers constructed, which covered total length 1783.9 cM an average marker interval 4.4 cM. The phenotyped eight natural environments...
Yield of rapeseed is determined by three components: silique number, seed number per and thousand weight. Seed weight are influenced length, density, breadth, thickness volume. Some QTLs for traits have been reported in B. napus, however, no studies focused on the six agronomic (seed silique, thickness, density volume) simultaneously, genetic determinism such complex not fully elucidated.In this study, were evaluated using 348 lines a doubled haploid population, KN population. The results...
Congestive heart failure (CHF) is a common cardiovascular disease that often accompanied by ventricular arrhythmias. The decrease of the slow component delayed rectifier potassium current (IKs) in CHF leads to action potential (AP) prolongation, and IKs an important contributor development However, molecular mechanisms underlying arrhythmias are still unknown.Kcna2 Kcna2 antisense RNA (Kcna2 AS) transcript expression was measured rat cardiac tissues using quantitative real-time reverse...
alpha-Synuclein has been implicated in the pathogenesis of Parkinson's disease (PD). Previous studies have shown that alpha-synuclein is involved regulation dopamine (DA) metabolism, possibly by down-regulating expression tyrosine hydroxylase (TH), rate-limiting enzyme DA biosynthesis. In this study, we constructed stably silenced MN9D/alpha-SYN(-) cells vector mediated RNA interference and examined its effects on metabolism. We found there were no significant differences TH protein mRNA...
A case-control study was conducted to examine the association between two single nucleotide polymorphisms (SNPs) in exon 2 of bone morphogenetic protein-2 gene (BMP-2) and ossification posterior longitudinal ligament (OPLL), investigate whether SNPs Ser37Ala (T/G) Ser87Ser (A/G) BMP-2 are associated with genetic susceptibility OPLL its severity Chinese subjects. The SNP has been implicated mineral density (BMD) increases risk OA women. is BMD rate loss osteoporosis fractures. total 57...
Sustained cardiac hypertrophy (CH) contributes to many heart diseases. Long noncoding RNAs (lncRNAs) collectively play critical roles in cardiovascular diseases (CVDs). However, the of lncRNA H19 CH are still unclear. A model was constructed utilizing isoproterenol (ISO). We demonstrated could participate regulating ISO-induced development both vivo and vitro. The online databases DIANA TargetScan were used predict targets MicroRNA-145-3p (miR-145-3p), respectively. Luciferase reporter assay...
Competing endogenous RNA (ceRNA) and autophagy were related to neurological diseases. But the relationship among ceRNA, Schizophrenia (SZ) was not clear. In this study, we obtained gene expression profile of SZ patients (GSE38484, GSE54578, GSE16930) from Gene Expression Omnibus (GEO) database. Then screened autophagy-related differentially expressed lncRNA, miRNA, mRNA (DElncRNA, DEmiRNA, DEmRNA) combined with database The National Center for Biotechnology Information (NCBI). addition,...
Uniportal video-assisted thoracoscopic surgery (VATS) lobectomy is an emerging technique for the surgical resection of non-small cell lung cancer (NSCLC). Besides its wide debates on safety and efficacy throughout world, there were few report uniportal VATS from Eastern countries. In this article, we summarized our primary experience in center.From October 2013 till February 2014, 54 consecutive performed Department Thoracic Surgery, Zhongshan Hospital Fudan University. Patients' clinical...
Mesenchymal stem cells (MSCs) treatment has emerged as a promising approach for treating Sjögren's syndrome (SS). Impaired immunoregulatory activities of bone marrow mesenchymal (BMMSCs) are found in both SS patients and animal models, the underlying mechanism is poorly understood. Increased expression BMP6 reported to be related SS. The aim herein was determine effects on BMMSCs function. were isolated from NOD mice showed high level expression. function investigated using vitro...
Gastric cancer (GC) is characterized by notable heterogeneity and the impact of molecular subtypes on treatment prognosis. The role programmed cell death (PCD) in cellular processes critical, yet its specific function GC underexplored. This study applied multiomics approaches, integrating transcriptomic, epigenetic, somatic mutation data, with consensus clustering algorithms to classify assess their biological immunological features. A machine learning model was developed create Cancer...
Abstract: Human olfactory mucosa mesenchymal-like stem cells (hOM-MSCs) secrete paracrine factors that may exert a protective effect on the cerebral ischemia. This study was done to determine hypoxic and ischemic effects mRNA protein expression level of by hOM-MSCs. The hOM-MSCs were cultured with 5% or 20% serum under either normoxic (21% O 2 ) (3% conditions. Expression levels for vascular endothelial growth factor (VEGF), nerve (NGF), brain-derived neurotrophic (BDNF), glial cell...
Miniature pigs, a valuable alternative model for understanding human tooth development, have deciduous teeth from all four families that are replaced once by permanent molars. The extracellular matrix (ECM) supports cells and maintains the integrity of germs during development. However, details on role ECM in development poorly understood. Here, we performed long noncoding RNA (lncRNA) messenger (mRNA) expression profiles components sequencing miniature pigs. From early cap to late bell...
Background Chronic rejection characterized by chronic allograft vasculopathy (CAV) remains a major obstacle to long-term graft survival. Due multiple complicated mechanisms involved, novel therapy for CAV exploration. Although mesenchymal stromal cells (MSCs) have been ubiquitously applied various refractory immune-related diseases, rare research makes thorough inquiry in CAV. Meanwhile, melatonin (MT), wide spectrum of immunomodulator, plays non-negligible role transplantation immunity....
Lung cancer leads to the most cancer-related death in world. It was shown from increasing evidences that long non-coding RNAs (lncRNAs) are emerging as molecules for diagnosis, prognosis and even therapy of lung other malignancies. The biological functions or involved signaling pathways lncRNAs always found be inconsistent among different types However, no available literature has systemically summarized differences underlying molecular mechanisms between cancers. In this review, were...