A5101789877- MicroRNA in disease regulation
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Plant Stress Responses and Tolerance
- RNA and protein synthesis mechanisms
- Machine Learning in Bioinformatics
- Hippo pathway signaling and YAP/TAZ
- Genomics and Phylogenetic Studies
- Cloud Data Security Solutions
- Extracellular vesicles in disease
- Cryptography and Data Security
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Trace Elements in Health
- Plant Molecular Biology Research
- Ultrasound and Hyperthermia Applications
- Liver Disease and Transplantation
- Hedgehog Signaling Pathway Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA regulation and disease
- Internet Traffic Analysis and Secure E-voting
- Nanoparticle-Based Drug Delivery
Institute of Botany
2023-2025
University of Chinese Academy of Sciences
2023-2025
University of Hong Kong
2025
Beijing Botanical Garden
2025
Northeast Agricultural University
2021-2025
Qilu Hospital of Shandong University
2025
Qingdao Agricultural University
2025
Hong Kong University of Science and Technology
2025
Georgia State University
2025
Chinese PLA General Hospital
2025
Di(2-ethylhexyl) phthalate (DEHP), which is widely used in agricultural plastics, accumulates humans and animals through the food chain over time, resulting liver toxicity. Recent studies have reported that pyroptosis mitochondrial damage are closely related to a variety of diseases, but specific mechanism still unclear. To address this issue, vitro vivo hepatotoxicity models were established. The results demonstrated exposure DEHP caused buildup MEHP livers, altered metabolite composition,...
Abstract The Hippo pathway plays an important role in organ development and adult tissue homeostasis, its deregulation has been implicated many cancers. signaling relies on a core kinase cascade culminating phosphorylation of the transcription coactivator Yorkie (Yki). Although Yki is key effector pathway, regulation protein stability still unclear. Here, we show that attenuates binding ubiquitin-specific protease Usp7 to Yki, which regulates through deubiquitinating Yki. Furthermore,...
Di-(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in plastic products, consumer and packaging materials. It of great health concern both animals humans it released into the environment entered body from products over time, thereby resulting neurotoxicity. As pivotal regulator central nervous system (CNS), astrocytes, are crucial for maintaining brain homeostasis. Nevertheless, underlying reason astrocyte neurotoxicity due to DEHP exposure remains incompletely understood....
Cadmium is a global ecological toxic pollutant; in animals, hepatotoxic fibrosis caused by bioaccumulation of Cd through food chains. We determined the path nano-Se antagonism Cd-induced hepatocyte pyroptosis targeting APJ-AMPK-PGC1α pathway, using an vivo model hepatotoxicity. All 1-day-old chicks were treated with (140 mg/kg BW/day) and/or (0.3 or 0.6 for 90 days. The result showed that (1.55 ± 0.148) activated NLRP3 inflammasome 49.903% as compared to Con group (1.034 0.008) release...
Abstract Emerging evidence suggests that long noncoding RNAs (lncRNAs) are involved in regulation of plant response to environmental stress. CBF/DREB1 s highly conserved transcription factors regulate cold stress plants. However, very few lncRNAs were found expression CBFs and tolerance plant. Here, we identified a cold‐responsive intergenic RNA ( MtCIR2 ) CBF / DREB1 genes located major freezing QTL region legume Medicago truncatula . We was more rapid than MtCBF/DREB1 during treatment....
Abstract Elucidating the expression of microRNAs in developing single cells is critical for functional discovery. Here, we construct scCAMERA (single-cell cartography microRNA based on reporter assay), utilizing promoter-driven fluorescent reporters conjunction with imaging and lineage tracing. The delineates transcriptional activity 54 conserved lineage-resolved throughout C. elegans embryogenesis. combinatorial partitions into fine clusters reflecting their function anatomy. Notably,...
Sleep disorders and diabetes mellitus are both prevalent increasingly common chronic diseases that significantly impact public health. Diabetes is a metabolic disorder characterized by hyperglycemia due to defective insulin secretion or action, leading multi-system complications. Notably, sleep disordersincluding obstructive apnea (OSA), insomnia, restless legs syndrome (RLS)are highly in diabetic populations often worsen glycemic dysregulation. impair sensitivity, trigger neuroinflammation...
Although colorectal cancer (CRC) is a prevalent malignancy of the digestive system, underlying mechanisms CRC tumorigenesis are still elusive. Arrestin-related domain-containing protein-3 (ARRDC3) has been reported to promote lysosome-mediated protein degradation. In present study, we find that expression ARRDC3 downregulated in specimens. Mechanistically, reveal binds and decreases oncoprotein YAP, cotranscription factor Hippo pathway. The regulation pathway by conserved from Drosophila...
QN Orange scallops are interspecific hybrids with orange adductor muscles that rich in carotenoids. In this study, analysis of miRNA expression profiles was performed to explore possible regulatory patterns involved carotenoid accumulation scallops. A total 91 differentially expressed between the white and were identified. GO KEGG target genes miRNAs revealed enrichments transmembrane transporter activity-related pathways, kinase signal transduction-related ATP binding cassette transporters...
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder influenced by both genetic and environmental factors. Identifying therapeutic targets interventions remains challenging. This study utilized Mendelian Randomization (MR) to investigate causal relationships between plasma proteins, lifestyle factors, AD, along with virtual screening identify potential drug compounds. A two-sample MR analysis assessed associations identified through genome-wide association studies (GWAS), AD...
PARP inhibitor (PARPi)-based synthetic lethal therapies have displayed limited benefits in BRCA-proficient ovarian cancer. To potentiate the application of PARPi, an ultrasound contrast agent OLA-NDs for delivery PARPi olaparib (OLA) was established enhancing DNA damage by blocking repair. were endowed with endogenous pH- and exogenous (US)-responsiveness to target tumors, as well contrast-enhanced US imaging diagnostic therapeutic integration. could upregulate NOX4 induce oxidative stress...
Introduction Osteonecrosis is a debilitating disease caused by impaired blood supply leading to bone tissue death, and drug-related osteonecrosis significant clinical issue.The role of inflammation metabolic disorders in the pathogenesis has garnered widespread attention, but exact causal relationships remain unclear.This study aims explore link between inflammatory cytokines osteonecrosis, while also investigating how metabolites might mediate this relationship. Material methods We employed...
Inflammatory bowel disease (IBD) is a chronic gastrointestinal that imposes severe health burden globally. Single-cell RNA sequencing (scRNA-seq) technology helps to elucidate the molecular characteristics and functional states of individual cells, thereby advancing study IBD's intricate mechanisms. Most current studies focus on small-scale samples from few cell subclusters, lacking large-scale, systematic analyses IBD. By collecting integrating multiple datasets, large-scale sample datasets...
The food calorie estimation system (FCES) is designed to record dietary information for diabetic patients monitor their intake estimate the number of calories they are consuming.Deep learning technologies have recently been used FCESs.In this work, we use neural network pattern recognition images calculate calories.In contrast traditional convolutional network, build a semantic segmentation model based on SegNet + MobileNet segment and extract area feature images.By determining corresponding...
Domestic animals show considerable genetic diversity. Previous studies suggested that animal phenotypes were affected by miRNA-mRNA interplay, but these focused mainly on the analysis of one or several interactions. However, in this study, we investigated and miRNA-lncRNA interactions a genomic scale using miranda targetscan algorithms. There has been strong directional artificial selection practiced during domestication animals. Thus, SNPs located miRNAs miRNA binding sites found 3'-UTRs...
Microwave hyperthermia is an emerging minimally invasive therapy in which thermal damage and apoptosis of tumor cells are induced by local heating tissues with microwave radiation. Recently, has been widely used clinical practice; however, uneven aggregation dispersion malignant tumors after the main problems associated this method. In work, a microridged waveguide antenna operating frequency 915 MHz was designed. Although its volume only 6.6 cm
Reversing the immunosuppressive tumor microenvironment (TME) in is widely deemed to be an effective strategy improve immune therapy. In particular, redox balance TME needs well controlled due its critical role mediating functions of various cells, including cancer cells and immune-suppressive cells.Here, we propose efficient reshape homeostasis reverse TME. Specifically, developed a microwave-chemo-immunostimulant CMMCP promote infiltration tumor-T by simultaneously reducing reactive oxygen...