Ultra-processed foods (UPFs) are linked to cardiometabolic diseases and neurologic outcomes, such as cognitive decline stroke. However, it is unclear whether food processing confers risk independent of dietary pattern information. We aimed (1) investigate associations between UPFs incident impairment stroke (2) compare these with other commonly recommended patterns in the REasons for Geographic Racial Differences Stroke study. This prospective, observational cohort study enrolled Black White...

Using movies has been accepted worldwide as a tool to help students learn medical professionalism. In the second year, group of conducted "Cinemeducation" project promote professionalism in "Medical Ethics and Critical Thinking" course.Five with issues were screened 20-30 attending each session. After show, participants then asked reflect on what they had learned terms Two led discussion emphasizing questioning argumentation for 60 min. Additional learning emerging from session also explored...

Traumatic brain injury frequently causes traumatic axonal (TAI) in white matter tracts. Experimental TAI the corpus callosum of adult mice was used to examine effects on oligodendrocyte lineage cells and myelin conjunction with neuroimaging. The targeted over subventricular zone, a source neural stem/progenitor cells. produced rostral body by impact onto skull at bregma. During first week after injury, magnetic resonance diffusion tensor imaging showed that axial diffusivity decreased...

In the United States, risk of stroke is greater among Black compared with that White individuals. However, reasons for difference in incidence are not fully elucidated. We aimed to identify metabolites account higher prevalent hypertension and incident ischemic adults.

Background Sex disparities exist in cardiometabolic diseases. Metabolomic profiling offers insight into disease mechanisms, as the metabolome is influenced by environmental and genetic factors. We identified metabolites associated with sex determined if sex‐associated are incident stoke, coronary heart disease, prevalent hypertension, chronic kidney disease. Methods Results Targeted metabolomics was conducted for 357 REGARDS (Reasons Geographic Racial Differences Stroke) case‐cohort substudy...

Concurrent acute ischemic stroke and myocardial infarction is an uncommon medical emergency condition. The challenge for the physicians regarding management of this situation paramount since early one condition will inevitably delay other. We present two illustrative cases "hyperacute simultaneous cardiocerebral infarction" who presented with arrived at hospital within thrombolytic therapeutic window 4.5 h. propose algorithm managing patient hyperacute based on hemodynamic status suggest...

Objective While dietary intake is linked to stroke risk, surrogate markers that could inform personalized interventions are lacking. We identified metabolites associated with diet patterns and incident in a nested cohort from the REasons for Geographic Racial Differences Stroke (REGARDS) study. Methods Levels of 162 were measured baseline plasma cases (n = 1,198) random controls 904). examined associations between plant‐based pattern previously reduced risk REGARDS. Secondary analyses...

After the initiation of COVID-19 vaccination program in Thailand, thousands patients have experienced unusual focal neurological symptoms. We report 8 with symptoms after receiving inactivated virus vaccine, CoronaVac.Patients were aged 24-48 years and 75% female. Acute onset occurred within first 24 h between 1-7d 25%. All presented lateralized sensory deficits, motor or both, 2-14 day duration. Migraine headache half patients. Magnetic resonance imaging brain during attacks did not...

The American Heart Association's Life's Simple 7 (LS7) is a health metric that captures important factors associated with cardiovascular and cerebrovascular health. Previous studies highlight the potential of plasma metabolites to serve as marker for lifestyle behavior could be target stroke prevention. objectives this study were identify LS7 incident ischemic mediate relationship between two.

The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) is a hybrid of the Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diets, its association with renal outcomes remains unclear. In REasons Geographic Racial Disparities in Stroke (REGARDS) cohort, diet data were collected at baseline using food frequency questionnaires. Modified Poisson regression was used examine MIND incident chronic kidney disease (CKD). REGARDS stroke case-cohort, 357 metabolites...

Targeted metabolomics was conducted on plasma samples from a nested case-cohort study within the biracial REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. This longitudinal investigates health outcomes with focus stroke disparities across United States, particularly Southeastern "Stroke Belt," where risk mortality are 2–4 times higher Black population. The REGARDS recruited 30,239 White participants aged 45 years or older. dataset includes 2,377 baseline collected...

Importance Although increasing evidence suggests that trimethylamine N-oxide (TMAO) is associated with atherosclerosis, little known about whether TMAO and its related metabolites (ie, choline, betaine, carnitine) are small vessel disease. Objective To evaluate the association between features of cerebral disease, including white matter hyperintensity volume (WMHV) acute lacunar infarction. Design, Setting, Participants This cross-sectional study included patients enrolled in Specialized...

Several metabolite markers are independently associated with incident ischemic stroke. However, prior studies have not accounted for intercorrelated networks. We used exploratory factor analysis (EFA) to determine if factors were Metabolites (n = 162) measured in a case-control cohort nested the REasons Geographic and Racial Differences Stroke (REGARDS) study, which included 1,075 stroke cases 968 random participants. Cox models adjusted age, gender, race, age-race interaction (base model)...

Abstract Background Acute vertigo is a common presentation of inner ear disease. However, it can also be caused by more serious conditions, especially posterior circulation stroke. Differentiating between these two conditions clinical presentations and imaging studies during the acute phase challenging. This study aimed to identify serum microRNA (miRNA) candidates that could differentiate stroke peripheral vertigo, among patients presenting with vertigo. Methods Serum levels six miRNAs...

In Thailand, almost one-quarter of strokes are related to atrial fibrillation (AF), and many could be prevented if AF were diagnosed treated prior the stroke. Therefore, we tested a novel strategy screen large numbers community residents using village health volunteers primary care nurses. Local nurses in Phetchaburi Lopburi provinces, Thailand trained perform screening blood pressure device with algorithm (Microlife A200 AFib). 10% aged ≥ 65 years randomly selected for during home-visits....

Neurocognitive impairment (NCI) contributes to poor quality of life among HIV-positive individuals. Cardiovascular risk factors, including the predictor subclinical atherosclerosis, carotid intima-media thickness (cIMT), are reported be associated with NCI. Data on NCI and its association cIMT HIV positive limited, especially in Asian populations. We aimed determine prevalence HIV-negative aging Thai Cognitive performance was evaluated by version Montreal Assessment (MoCA) a cutoff <25/30...

Chulalongkorn Stroke Center is a comprehensive stroke center (CSC) located in Bangkok, Thailand. Our network consists of different levels spoke hospitals, ranging from community hospitals where thrombolytic treatment not available, to those capable onsite therapy. This study aimed assess the time and outcomes among acute ischemic patients who received Network by 1.) Direct arrival at CSC (mothership) 2.) Telestroke-assisted with secondary transfer (drip-and-ship) 3.) Referral hospital for...

Thrombolytic treatment has been available for stroke in Thailand since 1996. The use of intravenous thrombolysis dramatically increased during the past 10 years. This is mainly due to fast track program that implemented throughout country. “stroke track” designed medical triage personnel at hospital identify patients who presented early order immediately notify team further investigation and management. establishment a telestroke network will be next step increase accessibility better care...

Introduction: Metabolic syndrome (MetS) increases the risk of cardiovascular disease and death. Previous ‘-omics’ studies have identified dysregulated serum metabolites aberrant DNA methylation in setting MetS. However, relationship between metabolome epigenome not been elucidated. In this study, we associated with MetS methylation, conducted bidirectional Mendelian randomization (MR) to assess causal relationships methylation. Methods: We leveraged metabolomic genomic data from a national...

ABSTRACT Leukemia/lymphoma‐related factor (LRF), a zinc‐finger transcription encoded by Zbtb7a , is protooncogene that regulates differentiation in diverse cell lineages, and the CNS, its function relatively unexplored. This study first to examine role of LRF CNS pathology. We examined expression murine viral model spinal cord demyelination with clinically relevant lesion characteristics. was rarely expressed oligodendrocyte progenitors (OP) yet, detected nuclei majority oligodendrocytes...

We report a 66-year-old female patient who presented with acute onset of visual loss relative afferent pupillary defect, hemineglect, hemihypesthesia, and apraxia. Magnetic resonance imaging the brain demonstrated different stages ischemic stroke in vascular territories, suggesting cardiogenic embolism. Past history was significant for advanced-stage adenocarcinoma uterine cervix under chemoradiation treatment. On echocardiogram, vegetation at aortic valve observed. With absence evidence...